CORC

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CORC

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BRD4 Targets the KEAP1-Nrf2-G6PD Axis and Suppresses Redox Metabolism in Small Cell Lung Cancer 期刊论文
ANTIOXIDANTS, 2022, 卷号: 11
作者:  Lv, Yang;  Lv, Xiaotong;  Zhang, Jiahui;  Cao, Guozhen;  Xu, Changzhi
收藏  |  浏览/下载：28/0  |  提交时间：2022/05/16
The Novel RET Inhibitor SYHA1815 Inhibits RET-Driven Cancers and Overcomes Gatekeeper Mutations by Inducing G1 Cell-Cycle Arrest through c-Myc Downregulation 期刊论文
MOLECULAR CANCER THERAPEUTICS, 2021, 卷号: 20, 期号: 11, 页码: 2198-2206
作者:  Jiang, Yuchen;  Peng, Xia;  Ji, Yinchun;  Dai, Yang;  Fang, Yanfen
收藏  |  浏览/下载：29/0  |  提交时间：2021/12/16
Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma 期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 2, 页码: 488-504
作者:  Liu, Xiaohua;  Zhang, Yu;  Li, Yalei;  Wang, Juan;  Ding, Huaqian
收藏  |  浏览/下载：30/0  |  提交时间：2021/05/24
Discovery of selective HDAC/BRD4 dual inhibitors as epigenetic probes 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 20
作者:  Chen, Jingjing;  Li, Yalei;  Zhang, Jie;  Zhang, Minmin;  Wei, Aihuan
收藏  |  浏览/下载：26/0  |  提交时间：2021/05/24
Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 7
作者:  Bi, Xiaoyang;  Chen, Yu;  Sun, Zhongya;  Lu, Wenchao;  Xu, Pan
收藏  |  浏览/下载：21/0  |  提交时间：2021/05/24
Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain 期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 101, 页码: 11
作者:  Chen, Yu;  Bi, Xiaoyang;  Zhang, Fengcai;  Sun, Zhongya;  Xu, Pan
收藏  |  浏览/下载：24/0  |  提交时间：2020/12/24
A new BET inhibitor, 171, inhibits tumor growth through cell proliferation inhibition more than apoptosis induction 期刊论文
INVESTIGATIONAL NEW DRUGS, 2020, 卷号: 38, 期号: 3, 页码: 700-713
作者:  Damaneh, Mohammadali Soleimani;  Hu, Jian-Ping;  Huan, Xia-Juan;  Song, Shan-Shan;  Tian, Chang-Qing
收藏  |  浏览/下载：36/0  |  提交时间：2020/07/01
BRD4 inhibitor nitroxoline enhances the sensitivity of multiple myeloma cells to bortezomib in vitro and in vivo by promoting mitochondrial pathway-mediated cell apoptosis 期刊论文
THERAPEUTIC ADVANCES IN HEMATOLOGY, 2020, 卷号: 11, 页码: 12
作者:  Li, Guang;  Zheng, Yan-Hua;  Xu, Li;  Feng, Juan;  Tang, Hai-Long
收藏  |  浏览/下载：46/0  |  提交时间：2020/12/24
Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 182, 页码: 21
作者:  Chen, Deheng;  Lu, Tian;  Yan, Ziqin;  Lu, Wenchao;  Lyu, Xilin
收藏  |  浏览/下载：28/0  |  提交时间：2020/07/01
Inhibition of the BET family reduces its new target gene IDO1 expression and the production of L-kynurenine 期刊论文
CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 13
作者:  Tian, Chang-Qing;  Chen, Lin;  Chen, Hua-Dong;  Huan, Xia-Juan;  Hu, Jian-Ping
收藏  |  浏览/下载：19/0  |  提交时间：2020/07/01

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