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浏览/检索结果:
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High chromosome instability identified by low-pass whole-genome sequencing assay is associated with TP53 copy loss and worse prognosis in BRCA1 germline mutation breast cancer
期刊论文
BREAST CANCER, 2021
作者:
Zhu, Liang
;
Pan, Jia-Ni
;
Qian, Ziliang
;
Ye, Wei-Wu
;
Wang, Xiao-Jia
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/09/06
CIN
TP53
BRCA1
LPWGS
Breast cancer
DAGM: A novel modelling framework to assess the risk of HER2-negative breast cancer based on germline rare coding mutations
期刊论文
EBIOMEDICINE, 2021, 卷号: 69, 页码: 11
作者:
Yang, Mei
;
Fan, Yanhui
;
Wu, Zhi-Yong
;
Gu, Jin
;
Feng, Zhendong
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/12/01
HER2-negative breast cancer
Germline rare coding mutations
Damage assessment of genomic mutations (DAGM)
Risk assessment
Activity profiles of signalling pathways (APSP)
HER2 signalling pathway
Immune suppression
Novel mutations in BRCA2 intron 11 and overexpression of COX-2 and BIRC3 mediate cellular resistance to PARP inhibitors
期刊论文
AMERICAN JOURNAL OF CANCER RESEARCH, 2020, 卷号: 10, 期号: 9, 页码: 2813-+
作者:
Chen, Hua-Dong
;
Guo, Ne
;
Song, Shan-Shan
;
Chen, Chuan-Huizi
;
Miao, Ze-Hong
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/12/24
PARP inhibitors resistance
BRCA2
COX-2
BIRC3
apoptotic resistance
Novel mutations in BRCA2 intron 11 and overexpression of COX-2 and BIRC3 mediate cellular resistance to PARP inhibitors
期刊论文
AMERICAN JOURNAL OF CANCER RESEARCH, 2020, 卷号: 10, 期号: 9, 页码: 2813-+
作者:
Chen, Hua-Dong
;
Guo, Ne
;
Song, Shan-Shan
;
Chen, Chuan-Huizi
;
Miao, Ze-Hong
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/12/24
PARP inhibitors resistance
BRCA2
COX-2
BIRC3
apoptotic resistance
Evaluation of the BRCAness phenotype and its correlations with clinicopathological features in triple-negative breast cancers
期刊论文
HUMAN PATHOLOGY, 2019, 卷号: 84
作者:
Tian, Tian
;
Shan, Ling
;
Yang, Wentao
;
Zhou, Xiaoyan
;
Shui, Ruohong
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
Triple-negative breast cancers
BRCAness
BRCA1-like genomic profile
BRCA1 promoter methylation
BRCA1/2 mutation
Multiple cancer susceptible genes sequencing in BRCA-negative breast cancers with high hereditary risk
会议论文
作者:
Lang, G-T
;
Hu, X.
;
Shao, Z-M
;
Huang, W.
;
Shi, J-X
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/05
germline mutation
BRCA-negative
hereditary breast cancer
multiple-gene sequencing
Patient-reported outcomes in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer receiving olaparib versus chemotherapy in the OlympiAD trial
期刊论文
2019, 卷号: 120, 页码: 20-30
作者:
Robson Mark
;
Ruddy Kathryn J
;
Im Seock-Ah
;
Senkus Elżbieta
;
Xu Binghe
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/01/03
BRCA
Breast cancer
EORTC QLQ-C30
Health-related quality of life
Olaparib
OlympiAD
OlympiAD final overall survival and tolerability results: Olaparib versus chemotherapy treatment of physician's choice in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer
期刊论文
2019, 卷号: 30, 期号: 4, 页码: 558-566
作者:
Robson, M. E.
;
Tung, N.
;
Conte, P.
;
Im, S-A
;
Senkus, E.
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/01/03
breast cancer
germline BRCA mutation
overall survival
PARP inhibitor
olaparib
tolerability
Subgroup analysis of olaparib monotherapy versus chemotherapy by hormone receptor and BRCA mutation status in patients with HER2-negative metastatic breast cancer and a germline BRCA mutation: OlympiAD
会议论文
作者:
Senkus-Konefka, E.
;
Domchek, S. M.
;
Im, S. A.
;
Xu, B.
;
Armstrong, A.
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/05
Tolerability of olaparib monotherapy versus chemotherapy in patients with HER2-negative metastatic breast cancer and a germline BRCA mutation: OlympiAD
期刊论文
CANCER RESEARCH, 2018, 卷号: 78, 期号: 4
作者:
Domchek, Susan M.
;
Robson, Mark
;
Im, Seock-Ah
;
Senkus, Elzbieta
;
Xu, Binghe
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
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