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CORC

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Virtual Screening for Type II B Inhibitors of B-Raf(V600E) Kinase 期刊论文
CURRENT COMPUTER-AIDED DRUG DESIGN, 2020
作者:  Qiu, Kai-Xiong;  Zhang, Wen;  Yu, Fang;  Li, Wei;  Sun, Zhong-Wen
收藏  |  浏览/下载：21/0  |  提交时间：2021/01/05
Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 2, 页码: 875-892
作者:  Liang, Xiaofei;  Wang, Beilei;  Chen, Cheng;  Wang, Aoli;  Hu, Chen
收藏  |  浏览/下载：19/0  |  提交时间：2020/05/21
Identification of the Raf kinase inhibitor TAK-632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2019, 卷号: 176, 期号: 12
作者:  Qin, Xia;  Hu, Longmiao;  Fu, Jing;  Miao, Zhenyuan;  Li, Zheng-gang
收藏  |  浏览/下载：72/0  |  提交时间：2019/12/05
Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy 期刊论文
ACTA PHARMACEUTICA SINICA B, 2018, 卷号: 8, 期号: 4, 页码: 552-562
作者:  Liu, Feifei;  Yang, Xiaotong;  Geng, Meiyu;  Huang, Min
收藏  |  浏览/下载：33/0  |  提交时间：2019/01/08
Design and discovery of thioether and nicotinamide containing sorafenib analogues as multikinase inhibitors targeting B-Raf, B-Raf(V600E) and VEGFR-2 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 9, 页码: 2381-2391
作者:  Sun, Shaofeng;  He, Zuopeng;  Huang, Mindong;  Wang, Ningning;  He, Zongzhong
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/11
Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of rapamycin 期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 64, 页码: 107977-107990
作者:  Xie, Chengying;  Chen, Xiangling;  Zheng, Mingyue;  Liu, Xiaohong;  Wang, Hongbin
收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08
Virtual screening of B-Raf kinase inhibitors: A combination of pharmacophore modelling, molecular docking, 3D-QSAR model and binding free energy calculation studies 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2017, 卷号: 70, 页码: 186-190
作者:  Zhang, Wen;  Qiu, Kai-Xiong;  Yu, Fang;  Xie, Xiao-Guang;  Zhang, Shu-Qun
收藏  |  浏览/下载：24/0  |  提交时间：2017/12/11
Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-Raf(V600E) inhibitors 期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 7, 页码: 1059-1068
作者:  Wang, Gui-min;  Wang, Xiang;  Zhu, Jian-ming;  Guo, Bin-bin;  Yang, Zhuo
收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08
嘧啶并吡啶酮骨架作为新型蛋白激酶小分子抑制剂的设计、合成及生物活性研究 学位论文
广州生物院: 中国科学院大学, 2017
作者:  余蕾
收藏  |  浏览/下载：434/0  |  提交时间：2018/12/25
Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells 期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 3, 页码: 5003-5015
作者:  Song, Qiaoling;  Sun, Xiaoxiao;  Guo, Hui;  Yu, Qiang
收藏  |  浏览/下载：19/0  |  提交时间：2019/01/08

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