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浏览/检索结果:
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The cross-talk between methylation and phosphorylation in lymphoid-specific helicase drives cancer stem-like properties
期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 卷号: 5, 期号: 1, 页码: 14
作者:
Liu, Na
;
Yang, Rui
;
Shi, Ying
;
Chen, Ling
;
Liu, Yating
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/12/21
Computational Prediction of Protein Arginine Methylation Based on Composition-Transition-Distribution Features
期刊论文
ACS OMEGA, 2020, 卷号: 5, 期号: 42, 页码: 27470-27479
作者:
Hou Ruiyan
;
Wu Jin
;
Xu Lei
;
Zou Quan
;
Wu YJ(伍一军)
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2021/10/26
A new chromatographic approach to analyze methylproteome with enhanced lysine methylation identification performance
期刊论文
ANALYTICA CHIMICA ACTA, 2019, 卷号: 1068, 页码: 111-119
作者:
Wang, Qi
;
Liu, Zhen
;
Wang, Keyun
;
Wang, Yan
;
Ye, Mingliang
收藏
  |  
浏览/下载:264/0
  |  
提交时间:2019/06/20
Methylproteome
Strong cation exchange
Immobilized metal ion affinity chromatography
High-pH reversed-phase chromatography
Lysine methylation identification
Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity
期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 8, 页码: 775-785
作者:
Zhu, Kongkai
;
Shao, Jingwei
;
Tao, Hongrui
;
Yan, Xue
;
Luo, Cheng
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
PRMT5 inhibitor
Anti-proliferative
Cellular target validation
Design and synthesis
Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 11, 页码: 5414-5433
作者:
Guo, Zuhao
;
Zhang, Zhuqing
;
Yang, Hong
;
Cao, Danyan
;
Xu, Xiaowei
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  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations
期刊论文
CHEMICAL & PHARMACEUTICAL BULLETIN, 2019, 卷号: 67, 期号: 4, 页码: 382-388
作者:
Tao, Hongrui
;
Yan, Xue
;
Zhu, Kongkai
;
Zhang, Hua
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
virtual screening
epigenetic inhibitor
antiproliferation
molecular docking
Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 317-333
作者:
Shao, Jingwei
;
Zhu, Kongkai
;
Du, Daohai
;
Zhang, Yuanyuan
;
Tao, Hongrui
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
PRMT5 inhibitors
N-Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
Anti-tumor
A patent review of arginine methyltransferase inhibitors (2010-2018)
期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2019, 卷号: 29, 期号: 2, 页码: 97-114
作者:
Li, Xiao
;
Wang, Chen
;
Jiang, Hao
;
Luo, Cheng
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/07/01
Arginine methylation
Protein arginine methyltransferases (PRMTs)
small molecule inhibitors
drug research and development
Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4 alpha
期刊论文
THERANOSTICS, 2019, 卷号: 9, 期号: 9, 页码: 2606-2617
作者:
Zheng, Bai-Nan
;
Ding, Chen-Hong
;
Chen, Shi-Jie
;
Zhu, Kongkai
;
Shao, Jingwei
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2020/07/01
PRMT5
HNF4 alpha
hepatocellular carcinoma
cancer stem cells
Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3693-3699
作者:
Zhu, Kongkai
;
Song, Jia-Li
;
Tao, Hong-Rui
;
Cheng, Zhi-Qiang
;
Jiang, Cheng-Shi
收藏
  |  
浏览/下载:100/0
  |  
提交时间:2019/01/08
Pharmacophore combination
Isoquinoline
PRMT5 inhibitor
Molecular docking
Molecular dynamics simulation
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