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Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 卷号: 21
作者:  Gao, Yang;  Wen, Pengbo;  Chen, Bin;  Hu, Guanshuo;  Wu, Lijun
收藏  |  浏览/下载:49/0  |  提交时间:2020/11/30
Radiosensitization of NSCLC cells to X-rays and carbon ions by the CHK1/CHK2 inhibitor AZD7762, Honokiol and Tunicamycin 期刊论文
RADIATION AND ENVIRONMENTAL BIOPHYSICS, 2020, 页码: 10
作者:  Liu, Bingtao;  Chen, Weiqiang;  Li, Hongbin;  Li, Feifei;  Jin, Xiaodong
收藏  |  浏览/下载:22/0  |  提交时间:2021/12/15
Acetyl-macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti-cancer effects with the Chk1/2 inhibitor AZD7762 期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 卷号: 365, 页码: 71-83
作者:  Wang, Jing-Nan;  Che, Yun;  Yuan, Zu-Yang;  Lu, Zhi-Liang;  Li, Yuan
收藏  |  浏览/下载:75/0  |  提交时间:2019/03/18
Acetyl-macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti-cancer effects with the Chk1/2 inhibitor AZD7762 期刊论文
2019, 卷号: 365, 页码: 71-83
作者:  Wang, Jing-Nan;  Che, Yun;  Yuan, Zu-Yang;  Lu, Zhi-Liang;  Li, Yuan
收藏  |  浏览/下载:3/0  |  提交时间:2020/01/03
Acetyl-macrocalin B, an ent-kaurane diterpenoid, initiates apoptosis through the ROS-p38-caspase 9-dependent pathway and induces G2/M phase arrest via the Chk1/2-Cdc25C-Cdc2/cyclin B axis in non-small cell lung cancer 期刊论文
CANCER BIOLOGY & THERAPY, 2018, 卷号: 19, 期号: 7, 页码: 609-621
作者:  Wang, Jing-Nan;  Zhang, Zhi-Rong;  Che, Yun;  Yuan, Zu-Yang;  Lu, Zhi-Liang
收藏  |  浏览/下载:111/0  |  提交时间:2018/07/16
Gemcitabine and Chk1 Inhibitor AZD7762 Synergistically Suppress the Growth of Lkb1-Deficient Lung Adenocarcinoma 期刊论文
CANCER RESEARCH, 2017, 卷号: 77, 期号: 18, 页码: 5068-5076
作者:  Liu, Yan;  Li, Yuyang;  Wang, Xiaoen;  Liu, Feiyang;  Gao, Peng
收藏  |  浏览/下载:34/0  |  提交时间:2018/08/16
Gemcitabine and Chk1 Inhibitor AZD7762 Synergistically Suppress the Growth of Lkb1-Deficient Lung Adenocarcinoma 期刊论文
CANCER RESEARCH, 2017, 卷号: 77, 期号: 18, 页码: 5068-5076
作者:  Liu, Yan;  Li, Yuyang;  Wang, Xiaoen;  Liu, Feiyang;  Gao, Peng
收藏  |  浏览/下载:3/0  |  提交时间:2019/12/11
Alternation of adriamycin penetration kinetics in MCF-7 cells from 2D to 3D culture based on P-gp expression through the Chk2/p53/NF-κB pathway 期刊论文
Biochemical Pharmacology, 2015, 卷号: 93, 期号: 2, 页码: 210-220
作者:  Lu, Meng;  Zhou, Fang;  Hao, Kun;  Liu, Jiali;  Chen, Qianying
收藏  |  浏览/下载:16/0  |  提交时间:2019/12/03
Adriamycin (PubChem CID: 31703)  LY335979 (PubChem CID: 153997)  AZD7762 (PubChem CID: 11152667)  Nutlin-3 (PubChem CID: 216345)  DMSO (PubChem CID: 679)  Propidium iodide (PubChem CID: 104981)  MTT formazan (PubChem CID: 16218671)  ADR  adriamycin  AUC  area under the concentration–time curve  ECM  extracellular matrix  ESI  electrospray ionization  HBSS  Hank's balanced salt solution  LC–MS/MS  liquid chromatography tandem mass spectrometry  MCL  multi-cellular layer  MCR  multi-cellular resistance  MCS  multi-cellular spheroid  MDR  multi-drug resistance  MRM  multiple reaction monitoring  P-gp  P-glycoprotein  PI  propidium iodide  qPCR  quantitative real-time PCR  S.E.  standard error  Multi-cellular layer  Penetration kinetics  P-gp  Chk2/p53/NF-κB pathway  
Design, synthesis and biological evaluation of thienopyridinones as Chk1 inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 17, 页码: 4882-4892
作者:  Song, Pinrao;  Peng, Peng;  Han, Mengmeng;  Cao, Xianchao;  Ma, Xiaodong
收藏  |  浏览/下载:22/0  |  提交时间:2019/01/08


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