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昆明植物研究所 [2]
合肥物质科学研究院 [2]
上海药物研究所 [1]
山东大学 [1]
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中国医学科学院 北京... [1]
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期刊论文 [9]
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Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 卷号: 21
作者:
Gao, Yang
;
Wen, Pengbo
;
Chen, Bin
;
Hu, Guanshuo
;
Wu, Lijun
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/11/30
CDC20
radiotherapy
Mcl-1
p-Chk1
mitochondrial-dependent apoptotic pathway
Radiosensitization of NSCLC cells to X-rays and carbon ions by the CHK1/CHK2 inhibitor AZD7762, Honokiol and Tunicamycin
期刊论文
RADIATION AND ENVIRONMENTAL BIOPHYSICS, 2020, 页码: 10
作者:
Liu, Bingtao
;
Chen, Weiqiang
;
Li, Hongbin
;
Li, Feifei
;
Jin, Xiaodong
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/12/15
Radiosensitivity
X-rays
Carbon ions
AZD7762
Honokiol
Tunicamycin
Acetyl-macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti-cancer effects with the Chk1/2 inhibitor AZD7762
期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 卷号: 365, 页码: 71-83
作者:
Wang, Jing-Nan
;
Che, Yun
;
Yuan, Zu-Yang
;
Lu, Zhi-Liang
;
Li, Yuan
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2019/03/18
Acetyl-macrocalin B
Reactive oxygen species
p38 MAPK
Chk1/Chk2
Esophageal squamous cell carcinoma
Acetyl-macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti-cancer effects with the Chk1/2 inhibitor AZD7762
期刊论文
2019, 卷号: 365, 页码: 71-83
作者:
Wang, Jing-Nan
;
Che, Yun
;
Yuan, Zu-Yang
;
Lu, Zhi-Liang
;
Li, Yuan
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/01/03
Acetyl-macrocalin B
Reactive oxygen species
p38 MAPK
Chk1/Chk2
Esophageal squamous cell carcinoma
Acetyl-macrocalin B, an ent-kaurane diterpenoid, initiates apoptosis through the ROS-p38-caspase 9-dependent pathway and induces G2/M phase arrest via the Chk1/2-Cdc25C-Cdc2/cyclin B axis in non-small cell lung cancer
期刊论文
CANCER BIOLOGY & THERAPY, 2018, 卷号: 19, 期号: 7, 页码: 609-621
作者:
Wang, Jing-Nan
;
Zhang, Zhi-Rong
;
Che, Yun
;
Yuan, Zu-Yang
;
Lu, Zhi-Liang
收藏
  |  
浏览/下载:111/0
  |  
提交时间:2018/07/16
Acetyl-macrocalin B
reactive oxygen species
p38 MAPK
apoptosis
Chk1
Chk2
G2
M phase arrest
NSCLC
Gemcitabine and Chk1 Inhibitor AZD7762 Synergistically Suppress the Growth of Lkb1-Deficient Lung Adenocarcinoma
期刊论文
CANCER RESEARCH, 2017, 卷号: 77, 期号: 18, 页码: 5068-5076
作者:
Liu, Yan
;
Li, Yuyang
;
Wang, Xiaoen
;
Liu, Feiyang
;
Gao, Peng
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2018/08/16
Gemcitabine and Chk1 Inhibitor AZD7762 Synergistically Suppress the Growth of Lkb1-Deficient Lung Adenocarcinoma
期刊论文
CANCER RESEARCH, 2017, 卷号: 77, 期号: 18, 页码: 5068-5076
作者:
Liu, Yan
;
Li, Yuyang
;
Wang, Xiaoen
;
Liu, Feiyang
;
Gao, Peng
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
Alternation of adriamycin penetration kinetics in MCF-7 cells from 2D to 3D culture based on P-gp expression through the Chk2/p53/NF-κB pathway
期刊论文
Biochemical Pharmacology, 2015, 卷号: 93, 期号: 2, 页码: 210-220
作者:
Lu, Meng
;
Zhou, Fang
;
Hao, Kun
;
Liu, Jiali
;
Chen, Qianying
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/03
Adriamycin (PubChem CID: 31703)
LY335979 (PubChem CID: 153997)
AZD7762 (PubChem CID: 11152667)
Nutlin-3 (PubChem CID: 216345)
DMSO (PubChem CID: 679)
Propidium iodide (PubChem CID: 104981)
MTT formazan (PubChem CID: 16218671)
ADR
adriamycin
AUC
area under the concentration–time curve
ECM
extracellular matrix
ESI
electrospray ionization
HBSS
Hank's balanced salt solution
LC–MS/MS
liquid chromatography tandem mass spectrometry
MCL
multi-cellular layer
MCR
multi-cellular resistance
MCS
multi-cellular spheroid
MDR
multi-drug resistance
MRM
multiple reaction monitoring
P-gp
P-glycoprotein
PI
propidium iodide
qPCR
quantitative real-time PCR
S.E.
standard error
Multi-cellular layer
Penetration kinetics
P-gp
Chk2/p53/NF-κB pathway
Design, synthesis and biological evaluation of thienopyridinones as Chk1 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 17, 页码: 4882-4892
作者:
Song, Pinrao
;
Peng, Peng
;
Han, Mengmeng
;
Cao, Xianchao
;
Ma, Xiaodong
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
Chk1 inhibitor
Thienopyridinones
Antitumor
Cell synergy
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