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GP-14 protects against severe hypoxia-induced neuronal injury through the AKT and ERK pathways and its induced transcriptome profiling alteration
期刊论文
Toxicology and Applied Pharmacology, 2022, 期号: 448, 页码: 116092
作者:
Ya-Nan Geng
;
Ming Zhao
;
Jun-Li Yang
;
Xiang Cheng
;
Ying Han
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2022/11/30
Gypenoside-14 (GP-14)
Neuronal Damage
Hypoxia
Transcriptome Sequencing
Neuroprotection
The Isolation and Preparation of Samwinol from Dracocephalum heterophyllum and Prevention on A beta(25-35)-Induced Neuroinflammation in PC-12 Cells
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 卷号: 23, 期号: 19
作者:
Li, CZ
;
Dang, J
;
Lv, Y
;
Fang, Y
;
Ma, CJ
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2022/12/02
DHOK Exerts Anti-Cancer Effect Through Autophagy Inhibition in Colorectal Cancer
期刊论文
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 卷号: 9
作者:
Shu, Yuhan
;
Sun, Xin
;
Ye, Guiqin
;
Xu, Mengting
;
Wu, Zhipan
收藏
  |  
浏览/下载:155/0
  |  
提交时间:2022/02/14
DHOK
transcriptome sequencing
autophagy
colorectal cancer
mTOR pathway
Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218, 页码: 14
作者:
Yang, Xiangbo
;
Wang, Zhijia
;
Pei, Yuan
;
Song, Ning
;
Xu, Lei
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/08/17
SHP2 degradation
Proteolysis targeting chimera (PROTAC)
Thalidomide-based heterobifunctional molecules
E3 ubiquitin ligase
CRBN
Third-generation EGFR inhibitor HS-10296 in combination with famitinib, a multi-targeted tyrosine kinase inhibitor, exerts synergistic antitumor effects through enhanced inhibition of downstream signaling in EGFR-mutant non-small cell lung cancer cells
期刊论文
THORACIC CANCER, 2021, 页码: 9
作者:
Zhang, Mi
;
Quan, Haitian
;
Fu, Li
;
Li, Yun
;
Fu, Haoyu
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/05/24
EGFR‐
mutant non‐
small cell lung cancer
famitinib
HS‐
10296
multi‐
targeted tyrosine kinase inhibitor
third‐
generation EGFR inhibitor
Chemerin reverses the malignant phenotype and induces differentiation of human hepatoma SMMC7721 cells
期刊论文
ARCHIVES OF PHARMACAL RESEARCH, 2021, 卷号: 44, 期号: 2
作者:
Li, Ming
;
Sun, Pengcheng
;
Dong, Kaikai
;
Xin, Ye
;
TaiLulu, Aslee
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/11/18
Chemerin
Human hepatic carcinoma SMMC7721 cells
Cell proliferation
Malignant phenotype
Cell differentiation
DCZ3301, an aryl-guanidino agent, inhibits ocular neovascularization via PI3K/AKT and ERK1/2 signaling pathways
期刊论文
EXPERIMENTAL EYE RESEARCH, 2020, 卷号: 201, 页码: 8
作者:
Xu, Kai
;
Li, Bo
;
Zhang, Shujie
;
Hu, Fangyuan
;
Xu, Zhijian
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/05/24
DCZ3301
Apoptosis
PI3K/AKT pathway
ERK1/2 pathway
Choroid microvascular sprouting
Corneal neovascularization
Structural elucidation of a pectin from roots of Polygala tenuifolia and its neuritogenesis inducing activity in PC12 cells
期刊论文
CARBOHYDRATE POLYMERS, 2020, 卷号: 236, 页码: 9
作者:
Zeng, Hui
;
Huang, Lulin
;
Tao, Hong
;
Zhang, Yiwen
;
Ding, Kan
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
Polygala tenuifolia
Pectin
Neuritogenesis
Neurodegenerative disorders
Structure-Activity Relationship of SPOP Inhibitors against Kidney Cancer
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 9, 页码: 4849-4866
作者:
Dong, Ze
;
Wang, Zhen
;
Guo, Zhong-Qiang
;
Gong, Shouzhe
;
Zhang, Tao
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2020/07/01
An optically active isochroman-2H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Tao, Ling-xue
;
Ji, Sha-sha
;
Szaloki, Dora
;
Kovacs, Tibor
;
Mandi, Attila
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
neurodegeneration
oxidative stress
apoptosis
MAPK pathway
PI3K
Akt pathway
SH-SY5Y neuroblastoma cells
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