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Discovery and Biological evaluation of pyrimido[4,5-d] pyrimidine-2,4(1H, 3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3390-3395
作者:
Diao, Yanyan
;
Fang, Xiaoyu
;
Song, Peiran
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
Bruton's tyrosine kinase
B-cell malignancies
Potent inhibitors
Structure-activity relationship
Cellular activities
CO2 involved synthesis of quinazoline-2,4(1H,3H)-diones in water using melamine as a thermoregulated catalyst
期刊论文
CANADIAN JOURNAL OF CHEMISTRY, 2019, 卷号: 97, 期号: 3, 页码: 212-218
作者:
Zhao, Guo-Ying
;
Mu, Ling-Ling
;
Ullah, Latif
;
Wang, Meng
;
Li, Hong-Ping
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  |  
浏览/下载:43/0
  |  
提交时间:2019/04/03
quinazoline-2
carbon dioxide
water
thermoregulated catalyst
cycloaddition
4(1H
3H)-diones
Succinimide-Based Ionic Liquids: An Efficient and Versatile Platform for Transformation of CO2 into Quinazoline-2,4(1H,3H)-diones under Mild and Solvent-Free Conditions
期刊论文
ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2019, 卷号: 7, 期号: 15, 页码: 13517-13522
作者:
Liu, Fusheng
;
Ping, Ran
;
Zhao, Penghui
;
Gu, Yongqiang
;
Gao, Jun
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  |  
浏览/下载:10/0
  |  
提交时间:2019/12/11
Carbon dioxide
Quinazoline-2,4(1H,3H)-dione
Succinimide-based ionic
liquids
Homogeneous catalysis
Multifunctional catalyst
Design, Synthesis, and Biological Evaluation of Pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 13, 页码: 5609-5622
作者:
Hao, Yongjia
;
Lyu, Jiankun
;
Qu, Rong
;
Tong, Yi
;
Sun, Deheng
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2019/01/08
Chlorination, chloramination and ozonation of carbamazepine enhance cytotoxicity and genotoxicity: Multi-endpoint evaluation and identification of its genotoxic transformation products
期刊论文
JOURNAL OF HAZARDOUS MATERIALS, 2018, 卷号: 342, 页码: 679-688
作者:
Oda, Yoshimitsu
;
Wang, Zijian
;
Huang, Chao
;
Hou, Rui
;
Li, Na
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  |  
浏览/下载:18/0
  |  
提交时间:2019/06/24
Anti-epileptic drug
Chlorine
Chloramine
Ozone
Bioassays
Facile and efficient synthesis of quinazoline-2,4(1H,3H)-diones through sequential hydrogenation condensation
期刊论文
2018, 卷号: 48, 期号: 10, 页码: 1183-1189
作者:
Wang, Peng-Xu
;
Wang, Ya-Nan
;
Lin, Zi-Yun
;
Li, Gang
;
Huang, Hai-Hong
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/01/03
Cascade reaction
heterocyclization
hydrogenation condensation
quinazoline-2
4(1H
3H)-dione
Discovery of quinazoline-2,4(1H,3H)-dione derivatives as novel PARP-1/2 inhibitors: design, synthesis and their antitumor activity
期刊论文
2018, 卷号: 16, 期号: 17, 页码: 3189-3202
作者:
Zhou, Jie
;
Ji, Ming
;
Yao, Haiping
;
Cao, Ran
;
Zhao, Hailong
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/01/03
Theoretical study on the mechanism of synthesis of (4R,5S,8as)-4,5,8a-triphenylhexahydropyrimido[4,5-d]pyrimidine-2,7(1H,3H)-dione
期刊论文
JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2017, 卷号: Vol.94 No.3, 页码: 299-310
作者:
Hu, QS
;
He, YQ
;
Li, LC
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/02/25
Density functional theory
Biginelli reaction
(4R,5S,8as)-4,5,8a-triphenylhexahydropyrimido[4,5-d]pyrimidine-2,7(1H,3H)-dione
one-pot synthesis
transition state
reaction mechanism
Discovery of novel quinazoline-2,4(1H,3H)-dione derivatives as potent PARP-2 selective inhibitors
期刊论文
2017, 卷号: 25, 期号: 15, 页码: 4045-4054
作者:
Zhao, Hailong
;
Ji, Ming
;
Cui, Guonan
;
Zhou, Jie
;
Lai, Fangfang
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/04
Quinazoline-2
4(1H
3H)-dione
PARP-2 selective inhibitor
Anti-tumor agents
Development of Quinoline-2,4(1H,3H)-diones as Potent and Selective Ligands of the Cannabinoid Type 2 Receptor
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 58, 期号: 15, 页码: 5751-5769
作者:
Han, Shuang
;
Zhang, Fei-Fei
;
Qian, Hai-Yan
;
Chen, Li-Li
;
Pu, Jian-Bin
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
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