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期刊论文 [21]
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Optimization of piperidine constructed peptidyl derivatives as proteasome inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 29, 页码: 14
作者:
Zhao, Yanmei
;
Xu, Lei
;
Zhang, Jiankang
;
Zhang, Mengmeng
;
Lu, Jingyi
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Proteasome inhibitor
Piperidine
Peptidyl
Anti-cancer
SAR
Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 602-614
作者:
Dong, Xiao-Wu
;
Zhang, Jian-Kang
;
Xu, Lei
;
Che, Jin-Xin
;
Cheng, Gang
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2020/07/01
Proteasome inhibitors
Tripeptide
Covalent docking
Interaction mode
Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 423-439
作者:
Yu, Jianjun
;
Liu, Jieyu
;
Li, Daqiang
;
Xu, Lei
;
Hong, Duidui
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  |  
浏览/下载:0/0
  |  
提交时间:2020/07/01
Proteasome inhibitors
Macrocyclic dipeptides
N-Benzyl amides
Metabolic stability
Design, synthesis, and biological evaluation of novel phenol ether derivatives as non-covalent proteasome inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 161, 页码: 543-558
作者:
Yu, Jianjun
;
Xu, Lei
;
Hong, Duidui
;
Zhang, Xiaotuan
;
Liu, Jieyu
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2019/01/08
Proteasome inhibitor
Non-covalent
Non-peptide
Phenol ether
Solid cancers
Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 20, 页码: 9177-9204
作者:
Li, Daqiang
;
Zhang, Xiaotuan
;
Ma, Xiaodong
;
Xu, Lei
;
Yu, Jianjun
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  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
Discovery of novel 20S proteasome inhibitors by rational topology-based scaffold hopping of bortezomib
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 12
作者:
Xu, Yulong
;
Yang, Xicheng
;
Chen, Yiyi
;
Chen, Hao
;
Sun, Huijiao
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
Proteasome inhibitors
Topology-based
Scaffold hopping
Bortezomib
Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 126, 页码: 1056-1070
作者:
Zhuang, Rangxiao
;
Gao, Lixin
;
Lv, Xiaoqing
;
Xi, Jianjun
;
Sheng, Li
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Proteasome inhibitors
Piperazine or piperidine
Non-covalent
Peptidyl derivatives
Anti-cancer
Design, synthesis and biological evaluation of novel non-covalent piperidine-containing peptidyl proteasome inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 卷号: 24, 期号: 23, 页码: 6206-6214
作者:
Zhang, Jiankang
;
Gao, Lixin
;
Xi, Jianjun
;
Sheng, Li
;
Zhao, Yanmei
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2019/01/08
Proteasome inhibitors
Piperidine
Non-covalent
Anti-cancer
SARs
Discovery of a potent and highly specific beta(2) proteasome inhibitor from a library of copper complexes
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016
Zhou, Tongliang
;
Cai, Yuanbo
;
Liang, Lei
;
Yang, Lingfei
;
Xu, Fengrong
;
Niu, Yan
;
Wang, Chao
;
Zhang, Jun-Long
;
Xu, Ping
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2017/12/03
Proteasome inhibitors
Schiff base
Copper complex
Drug design
Structure-activity relationships
20S PROTEASOME
CANCER-CELLS
PLATINUM COMPOUNDS
DRUG DEVELOPMENT
SCHIFF-BASES
N-ARYLATION
APOPTOSIS
ANTICANCER
INDUCTION
UBIQUITIN
Progress in Study of Clarifying The Structure and The Mechanisms That Regulate The Activity of The Proteasome
期刊论文
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2015, 卷号: 42, 期号: 12, 页码: 1084-1093
作者:
Sun Peng
;
Liu Miao
;
Feng Li-Xing
;
Liu Xuan
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
proteasome
structure
transcriptional regulation
post-translational modification
subunit assembly
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