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浏览/检索结果: 共23条，第1-10条 帮助 限定条件 发表日期：2021    内容类型：期刊论文    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9 作者:  Li, Teng-teng;  Peng, Cheng;  Wang, Ji-qiu;  Xu, Zhi-jian;  Su, Ming-bo 收藏  |  浏览/下载：42/0  |  提交时间：2022/01/18 DPP4  distal mutation  enzymatic activity  molecular dynamics simulation  structure-function mechanism   Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors 期刊论文 BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13 作者:  Meng, Xiang-Dong;  Gao, Li-Xin;  Wang, Zhi-Jia;  Feng, Bo;  Zhang, Chun 收藏  |  浏览/下载：31/0  |  提交时间：2021/12/01 2,5-diphenyl-1,3,4-oxadiazole derivatives  SHP2  Inhibitors  Structure-activity relationships (SAR)   Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13 作者:  Chen, Yun;  Bai, Gang;  Li, Yan;  Ning, Yi;  Cao, Sufen 收藏  |  浏览/下载：32/0  |  提交时间：2021/12/01 FLT3  FLT3-ITD  Acute myeloid leukemia  Structure-activity relationships  Pyrazolo[1, 5-a]pyrimidine   Picomolar antimalarial agent from a Chinese medicinal plant 期刊论文 SCIENCE CHINA-CHEMISTRY, 2021, 页码: 5 作者:  Zhou, Bin;  Zimbres, Flavia M.;  Butler, Joshua H.;  Xu, Cheng-Hui;  Haney, Reagan S. 收藏  |  浏览/下载：62/0  |  提交时间：2021/12/01 medicinal plants  dimeric sesquiterpenoids  antimalarial agent  structure-activity relationship   Insights into agonist-elicited activation of the human glucose-dependent insulinotropic polypeptide receptor 期刊论文 BIOCHEMICAL PHARMACOLOGY, 2021, 卷号: 192, 页码: 16 作者:  Yuliantie, Elita;  van der Velden, Wijnand J. C.;  Labroska, Viktorija;  Dai, Antao;  Zhao, Fenghui 收藏  |  浏览/下载：44/0  |  提交时间：2021/11/04 Glucose-dependent insulinotropic polypeptide receptor  G protein-coupled receptor  GPCR structure-function relationship  ERK  cAMP  Arrestin   Structure-Based Virtual Screening and Identification of Potential Inhibitors of SARS-CoV-2 S-RBD and ACE2 Interaction 期刊论文 FRONTIERS IN CHEMISTRY, 2021, 卷号: 9, 页码: 12 作者:  Xiong, Jiacheng;  Xiang, Yusen;  Huang, Ziming;  Liu, Xiaohong;  Wang, Mengge 收藏  |  浏览/下载：41/0  |  提交时间：2021/12/01 SARS-CoV-2  angiotensin-converting enzyme 2 (ACE2)  spike protein receptor-binding domain (S-RBD)  structure-based virtual screening  protein-protein interaction (PPI) inhibitors   A hybrid framework for improving uncertainty quantification in deep learning-based QSAR regression modeling 期刊论文 JOURNAL OF CHEMINFORMATICS, 2021, 卷号: 13, 期号: 1, 页码: 17 作者:  Wang, Dingyan;  Yu, Jie;  Chen, Lifan;  Li, Xutong;  Jiang, Hualiang 收藏  |  浏览/下载：60/0  |  提交时间：2021/11/04 Uncertainty quantification  Quantitative structure-activity relationship  Bayesian neural network  Applicability domain  Bayesian inference  Error prediction  Artificial intelligence   Forrestiacids A and B, Pentaterpene Inhibitors of ACL and Lipogenesis: Extending the Limits of Computational NMR Methods in the Structure Assignment of Complex Natural Products 期刊论文 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 7 作者:  Xiong, Juan;  Zhou, Peng-Jun;  Jiang, Hao-Wen;  Huang, Ting;  He, Yu-Hang 收藏  |  浏览/下载：89/0  |  提交时间：2021/11/04 forrestiacids  lipogenesis inhibitors  natural products  structure elucidation  terpenoids   Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1) 期刊论文 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105 作者:  Yu Lijie;  Feng Bo;  Wang Zhijia;  Gao Lixin;  Zhang Chun 收藏  |  浏览/下载：242/0  |  提交时间：2021/11/04 5-phenyl-1,3,4-thiadiazole derivatives  Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1)  inhibitors  structure-activity relationships   NaNbO3-(Bi0.5Li0.5)TiO3 Lead-Free Relaxor Ferroelectric Capacitors with Superior Energy-Storage Performances via Multiple Synergistic Design 期刊论文 ADVANCED ENERGY MATERIALS, 2021, 页码: 12 作者:  Xie, Aiwen;  Zuo, Ruzhong;  Qiao, Zhenliang;  Fu, Zhengqian;  Hu, Tengfei 收藏  |  浏览/下载：67/0  |  提交时间：2021/08/17 energy-storage capacitors  lead-free relaxor ferroelectrics  multiscale structure evolution  nanodomains