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科研机构
合肥物质科学研究院 [16]
内容类型
期刊论文 [16]
发表日期
2022 [2]
2021 [2]
2020 [2]
2019 [1]
2018 [1]
2017 [1]
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专题:合肥物质科学研究院
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Discovery of Pyrrolo[2,3-d]pyrimidine derivatives as potent and selective colony stimulating factor 1 receptor kinase inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243
作者:
Liang, Xiaofei
;
Wang, Chun
;
Wang, Beilei
;
Liu, Juan
;
Qi, Shuang
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2022/12/23
CSF1R inhibitor
Kinase inhibitor
Macrophage polarization
PEG-Bottlebrush Stabilizer-Based Worm-like Nanocrystal Micelles with Long-Circulating and Controlled Release for Delivery of a BCR-ABL Inhibitor against Chronic Myeloid Leukemia (CML)
期刊论文
PHARMACEUTICS, 2022, 卷号: 14
作者:
Liang, Huamin
;
Zou, Fengming
;
Fu, Liyi
;
Liu, Qingwang
;
Wang, Beilei
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/12/23
drug nanocrystal
stabilizer
micelle
BCR-ABL
chronic myeloid leukemia (CML)
Nanocrystal-loaded liposome for targeted delivery of poorly water-soluble antitumor drugs with high drug loading and stability towards efficient cancer therapy
期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 卷号: 599
作者:
Liang, Huamin
;
Zou, Fengming
;
Liu, Qingwang
;
Wang, Beilei
;
Fu, Liyi
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2021/05/17
Liposome
Drug nanocrystal
Core-shell
Drug delivery
Tumor therapy
BCR-ABL
Selectively targeting FLT3-ITD mutants over FLT3-wt by a novel inhibitor for acute myeloid leukemia
期刊论文
HAEMATOLOGICA, 2021, 卷号: 106
作者:
Wang, Aoli
;
Hu, Chen
;
Chen, Cheng
;
Liang, Xiaofei
;
Wang, Beilei
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/04/26
An ultra-long circulating nanoparticle for reviving a highly selective BCR-ABL inhibitor in long-term effective and safe treatment of chronic myeloid leukemia
期刊论文
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2020, 卷号: 29
作者:
Fu, Liyi
;
Zou, Fengming
;
Liu, Qingwang
;
Wang, Beilei
;
Wang, Junqing
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/11/30
Chronic myeloid leukemia
BCR-ABL
Long-circulating nanoparticle
Drug delivery
Discovery of 6 '-chloro-N-methyl-5 '-(phenylsulfonamido)-[3,3 '-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 188
作者:
Liang, Xiaofei
;
Jiang, Zongru
;
Huang, Zhenghui
;
Li, Feng
;
Chen, Cheng
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/11/26
PI4K kinase
Kinase inhibitor
Malaria
Blood stage
Liver stage
Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 2, 页码: 875-892
作者:
Liang, Xiaofei
;
Wang, Beilei
;
Chen, Cheng
;
Wang, Aoli
;
Hu, Chen
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/05/21
Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3K delta) inhibitor
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 156, 页码: 831-846
作者:
Liang, Xiaofei
;
Li, Feng
;
Chen, Cheng
;
Jiang, Zongru
;
Wang, Aoli
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/10
PI3K delta
Kinase inhibitor
Acute myeloid leukemia
Structure-activity relationship
Discovery of 2-((3-Acrylamido-4-methylphenyl)amino)-N-(2-methyl5-(3,4,5-trimethoxybenzamido)phenyI)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-BMX-078) as a Highly Potent and Selective Type II Irreversible Bone Marrow Kinase in the X Chromosome (BMX) Kinase Inhibitor
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 5, 页码: 1793-1816
作者:
Liang, Xiaofei
;
Lv, Fengchao
;
Wang, Beilei
;
Yu, Kailin
;
Wu, Hong
收藏
  |  
浏览/下载:721/0
  |  
提交时间:2018/07/04
Simultaneous inhibition of Vps34 kinase would enhance PI3K delta inhibitor cytotoxicity in the B-cell malignancies
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 33, 页码: 53515-53525
作者:
Liu, Xiaochuan
;
Wang, Aoli
;
Liang, Xiaofei
;
Liu, Juanjuan
;
Zou, Fengming
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2017/11/21
Pi3k Delta
Vps34
Combination
Chronic Lymphatic Leukemia
Acute Myeloid Leukemia
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