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中国医学科学院 北... [20]
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期刊论文 [20]
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2019 [8]
2018 [3]
2017 [4]
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专题:中国医学科学院 北京协和医学院
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Physcion and physcion 8-O-beta-glucopyranoside: A review of their pharmacology, toxicities and pharmacokinetics
期刊论文
2019, 卷号: 310, 页码: 108722
作者:
XunLi
;
Liu, Yingjiao
;
Chu, Shifeng
;
Yang, Songwei
;
Peng, Ye
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/01/03
Physcion
Physcion 8-O-beta-glucopyranoside
Pharmacology
Toxicity
Pharmacokinetics
A Narrative Review of Cancer-Related Fatigue (CRF) and Its Possible Pathogenesis
期刊论文
2019, 卷号: 8, 期号: 7
作者:
Yang, Songwei
;
Chu, Shifeng
;
Gao, Yan
;
Ai, Qidi
;
Liu, Yingjiao
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/01/03
cancer-related fatigue
peripheral immune activation
skeletal muscle
mitochondrion
inflammatory cytokines
central nervous system
Metabolism of IMM-H004 and Its Pharmacokinetic-Pharmacodynamic Analysis in Cerebral Ischemia/Reperfusion Injured Rats
期刊论文
2019, 卷号: 10, 页码: 631
作者:
Zhang, Ziqian
;
Liu, Dandan
;
Jiang, Jianwei
;
Song, Xiuyun
;
Zou, Xiaowen
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/01/03
drug metabolism
pharmacokinetic/pharmacodynamics (PK/PD)
UDP-glucuronosyltransferases
cytochromes P450
cerebral ischemia
neuroprotection
IMM-H004
Neuroprotective Effects of Anthraquinones from Rhubarb in Central Nervous System Diseases
期刊论文
2019, 卷号: 2019, 页码: 3790728
作者:
Li, Xun
;
Chu, Shifeng
;
Liu, Yinjiao
;
Chen, Naihong
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/03
IMM-H004 therapy for permanent focal ischemic cerebral injury via CKLF1/CCR4-mediated NLRP3 inflammasome activation
期刊论文
2019, 卷号: 212, 页码: 36-53
作者:
Ai Q D
;
Chen Chen
;
Chu Shifeng
;
Zhang Zhao
;
Luo Yun
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/01/03
ASC = apoptosis-associated speck-like protein containing a caspase activation recruitment domain
BCA = bicinchoninic acid
BSA = bovine serum albumin
CCA = common carotid artery
CCR4 = C-C chemokine receptor type 4
CKLF1 = chemokine-like factor 1
CO-IP = coimmunoprecipitation
ECA = external carotid artery
ELISA = enzyme-linked immunosorbent assay
FDA = Food and Drug Administration
I/R = ischemic/reperfusion
ICA = internal carotid artery
IL-18 = interleukin 18
IL-1β = interleukin 1β
LDH = lactate dehydrogenase
NLRP3 = NOD-like receptor protein 3
PBS = phosphate-buffered saline
SD = standard deviation
TNF-α = tumor necrosis factor α
TTC = 2
3
5-triphenyltetrazolium-chloride
WT = wild-type
pMCAO = permanent middle cerebral artery occlusion
pro-Caspase-1 = precursor Caspase-1
qPCR = quantitative real-time PCR
tMCAO = transient middle cerebral artery occlusion
tPA = tissue plasminogen activator
IMM-H004 Protects against Cerebral Ischemia Injury and Cardiopulmonary Complications via CKLF1 Mediated Inflammation Pathway in Adult and Aged Rats
期刊论文
2019, 卷号: 20, 期号: 7
作者:
Ai, Qidi
;
Chen, Chen
;
Chu, Shifeng
;
Luo, Yun
;
Zhang, Zhao
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/01/03
IMM-H004
cerebral ischemia
complication
CKLF1
inflammation
aged rats
A20 as a novel target for the anti-neuroinflammatory effect of chrysin via inhibition of NF-kappa B signaling pathway
期刊论文
2019, 卷号: 79, 页码: 228-235
作者:
Li, Zhipeng
;
Chu, Shifeng
;
He, Wenbin
;
Zhang, Zhao
;
Liu, Jiaqi
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/03
Chrysin
Neuroinflammation
NF-kappa B
A20
TRAF6
IMM-H004 protects against oxygen-glucose deprivation/reperfusion injury to BV2 microglia partly by modulating CKLF1 involved in microglia polarization
期刊论文
2019, 卷号: 70, 页码: 69-79
作者:
Chen, Chen
;
Ai, Qidi
;
Chu, Shifeng
;
Zhang, Zhao
;
Zhou, Xin
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/01/03
IMM-H004
CKLF1
BV2 microglia
OGD/R
Microglia polarization
Antidepressant-like effect of active fraction of Polyrhachisvicina Roger in a rat depression model
期刊论文
2018, 卷号: 38, 期号: 1, 页码: 12-21
作者:
Wei Guining
;
Chu Shifeng
;
Su Qibiao
;
Su Hua
;
Lin Meiyu
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/01/03
Depression
Polyrhachis vicina Roger
Ether
Ethanol
Monoamine oxidase
Hypouricemic and Nephroprotective Effects of an Active Fraction from Polyrhachis Vicina Roger On Potassium Oxonate-Induced Hyperuricemia in Rats
期刊论文
2018, 卷号: 43, 期号: 1, 页码: 220-233
作者:
Su, Qibiao
;
Su, Hua
;
Nong, Zhihuan
;
Li, Dongmei
;
Wang, Laiyou
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/01/03
Polyrhachis vicina Roger
Hyperuricemia
Nephroprotective
Xanthine oxidase
Uric acid transporters
Inflammatory response
Oxidative stress
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