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浏览/检索结果: 共7条，第1-7条 帮助 限定条件 专题：中南大学    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 IncRNA ZEB1-AS1 Was Suppressed by p53 for Renal Fibrosis in Diabetic Nephropathy 期刊论文 MOLECULAR THERAPY-NUCLEIC ACIDS, 2018, 卷号: 12, 页码: 741-750 作者:  Wang, Juan;  Pang, Jian;  Li, Huiling;  Long, Jie;  Fang, Fang 收藏  |  浏览/下载：2/0  |  提交时间：2019/12/03 p53 activates miR-192-5p to mediate vancomycin induced AKI 期刊论文 Scientific Reports, 2016, 卷号: 6, 页码: 38868 作者:  Chen, Jinwen;  Wang, Juan;  Li, Huiling;  Wang, Shixuan;  Xiang, Xudong 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03 AAL exacerbates pro-inflammatory response in macrophages by regulating Mincle/Syk/Card9 signaling along with the Nlrp3 inflammasome assembly. 期刊论文 AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2015, 卷号: 7, 期号: 10, 页码: 1812-1825 作者:  Zhang, Zhijun;  He, Long;  Hu, Shuang;  Wang, Yi;  Lai, Qiaohong 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03 AAL  CLP  Hmgb1  NF-kappaB  Nlrp3 inflammasome  innate immunity  methylation  mincle  septic shock   Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling 期刊论文 Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 2139-2148 作者:  Zhang, Lei;  Xu, Xuan;  Yang, Ruhao;  Chen, Jingwen;  Wang, Shixuan 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03 Recent studies have demonstrated that paclitaxel might inhibit renal fibrosis. However  the underlying molecular mechanism remains unclear. In this study  we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis in a mouse model with unilateral ureteral obstruction. Both NRK-49F cells and mice with unilateral ureteral obstruction were treated with paclitaxel. The results showed that paclitaxel treatment resulted in a dose- and time-dependent decrease in tyrosine-phosphorylated STAT3  and inhibited the expression of fibronectin  alpha-smooth muscle actin (α-SMA)  and collagen I in cultured NRK-49F cells. S3I-201  an STAT3 inhibitor  also suppressed the expression of fibronectin  α-SMA  and collagen I in cultured NRK-49F cells. Mechanistically  paclitaxel treatment blocked the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation. Furthermore  paclitaxel also ameliorated renal fibrosis by down-regulating the expression of fibronectin  α-SMA  and collagen I  and suppressed the infiltration of macrophages and production of TNF-α  IL-1β  TGF-β  and ICAM-1 (intercellular adhesion molecule 1) by inhibition of STAT3 activity in obstructive nephropathy. These results suggest that paclitaxel may block the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation  consequently leading to the suppression of renal interstitial fibroblast activation and the development of renal fibrosis  and inhibition of proinflammatory cytokine production.   HMGB1 Enhances the AGE-Induced Expression of CTGF and TGF-beta via RAGE-Dependent Signaling in Renal Tubular Epithelial Cells. 期刊论文 American Journal of Nephrology, 2015, 卷号: 41, 期号: 3, 页码: 257-266 作者:  Cheng, Meichu;  Liu, Hong;  Zhang, Dongshan;  Liu, Yinghong;  Wang, Chang 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03 Advanced glycation end products  TGF-beta  CTGF  High mobility group box 1  Renal epithelial cell   Paclitaxel: new uses for an old drug 期刊论文 Drug Design, Development and Therapy, 2014, 卷号: 8, 页码: 279-284 作者:  Zhang, Dongshan;  Yang, Ruhao;  Wang, Shixuan;  Dong, Zheng* 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03 coronary artery restenosis  fibrosis  kidney  limb salvage  taxol inflammation   Low-dose paclitaxel ameliorates renal fibrosis in rat UUO model by inhibition of TGF-β/Smad activity 期刊论文 Laboratory Investigation, 2010, 卷号: 90, 期号: 3, 页码: 436-447 作者:  Dongshan Zhang;  Lin Sun;  Wang xian;  Fuyou Liu;  Guanghui Ling 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03 TGF-beta  UUO  tubulointerstitial fibrosis  microtubule  paclitaxel  Smad