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科研机构
上海药物研究所 [14]
内容类型
期刊论文 [14]
发表日期
2020 [1]
2019 [3]
2018 [4]
2017 [1]
2016 [3]
2014 [1]
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专题:上海药物研究所
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Determination of the antidiabetic chemical basis of Phellodendri Chinensis Cortex by integrating hepatic disposition in vivo and hepatic gluconeogenese inhibition in vitro
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2020, 卷号: 263, 页码: 10
作者:
Tian, Xiaoting
;
Xu, Zhou
;
Hu, Pei
;
Yu, Yanyan
;
Li, Zhixiong
收藏
  |  
浏览/下载:74/0
  |  
提交时间:2020/12/21
Phellodendri Chinensis cortex
Hepatic disposition
Pharmacokinetics
Berberine
Metabolites
Hepatic gluconeogenesis
Determining the protective effects of Yin-Chen-Hao Tang against acute liver injury induced by carbon tetrachloride using 16S rRNA gene sequencing and LC/MS-based metabolomics
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 174, 页码: 567-577
作者:
Liu, Fang
;
Sun, Zhaolin
;
Hu, Pei
;
Tian, Qiang
;
Xu, Zhou
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
Yin-Chen-Hao Tang
Liver injury
Metabolomics
Gut microbiota
LC-MS
Gene sequencing
Evaluation of the chemical consistency of Yin-Chen-Hao-Tang prepared by combined and separated decoction methods using high-performance liquid chromatography and quadrupole time-of-flight mass spectrometry coupled with multivariate statistical analysis
期刊论文
JOURNAL OF SEPARATION SCIENCE, 2019, 卷号: 42, 期号: 9, 页码: 1664-1675
作者:
Tian, Qiang
;
Liu, Fang
;
Xu, Zhou
;
Liu, Huan
;
Yin, Hao
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
chemical consistency
metabolomics
quadrupole time-of-flight mass spectrometry
Traditional Chinese medicines
Enhanced Anti-diabetic Effect of Berberine Combined With Timosaponin B2 in Goto-Kakizaki Rats, Associated With Increased Variety and Exposure of Effective Substances Through Intestinal Absorption
期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 15
作者:
Tian, Xiaoting
;
Liu, Fang
;
Li, Zhixiong
;
Lin, Yunfei
;
Liu, Huan
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
berberine
timosaponin B2
diabetes
combination treatments
drug-drug interaction
metabolites
hepatic metabolism
intestinal absorption
Chinese medicine CGA formula ameliorates liver fibrosis induced by carbon tetrachloride involving inhibition of hepatic apoptosis in rats
期刊论文
Journal of ethnopharmacology, 2018
作者:
Tian, Huajie
;
Liu, Lin
;
Li, Zhixiong
;
Liu, Wei
;
Sun, Zhaolin
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2019/01/08
Simultaneous determination of eight bioactive compounds by LC-MS/MS and its application to the pharmacokinetics, liver first-pass effect, liver and brain distribution of orally administrated Gouteng-Baitouweng (GB) in rats
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2018, 卷号: 1084, 页码: 122-131
作者:
Tian, Xiaoting
;
Xu, Zhou
;
Chen, Mingcang
;
Hu, Pei
;
Liu, Fang
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
Gouteng-Baitouweng
LC-MS/MS
Pharmacokinetics
Liver
Brain
liver first-pass effect
A sensitive HPLC-MS/MS method for the simultaneous determination of anemoside B4, anemoside A3 and 23-hydroxybetulinic acid: Application to the pharmacokinetics and liver distribution of Pulsatilla chinensis saponins
期刊论文
BIOMEDICAL CHROMATOGRAPHY, 2018, 卷号: 32, 期号: 3
作者:
Guo, Xiaozhen
;
Xie, Yang
;
Lian, Shan
;
Li, Zhixiong
;
Gao, Yu
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
23-hydroxybetulinic acid
HPLC-MS
MS
liver distribution
pharmacokinetics
Pulsatilla chinensis saponins
Absorption, liver first-pass effect, pharmacokinetics and tissue distribution of calycosin-7-O-beta-D-glucopyranoside (C7G) and its major active metabolite, calycosin, following oral administration of C7G in rats by LC-MS/MS
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2018, 卷号: 148, 页码: 350-354
作者:
Tian, Xiaoting
;
Chen, Shuoji
;
Zhang, Yuanyuan
;
Chen, Luying
;
Guo, Xiaozhen
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
Calycosin-7-O-beta-D-glucopyranoside
Calycosin
Pharmacokinetics
Liver first-pass effect
Tissue distribution
The metabolic ER stress sensor IRE1 alpha suppresses alternative activation of macrophages and impairs energy expenditure in obesity
期刊论文
NATURE IMMUNOLOGY, 2017, 卷号: 18, 期号: 5, 页码: 519-529
作者:
Shan, Bo
;
Wang, Xiaoxia
;
Wu, Ying
;
Xu, Chi
;
Xia, Zhixiong
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/01/08
Pharmacokinetics of mangiferin and its metabolite-Norathyriol, Part 1: Systemic evaluation of hepatic first-pass effect in vitro and in vivo
期刊论文
BIOFACTORS, 2016, 卷号: 42, 期号: 5, 页码: 533-544
作者:
Tian, Xiaoting
;
Gao, Yu
;
Xu, Zhou
;
Lian, Shan
;
Ma, Yuanjie
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
mangiferin
norathyriol
pharmacokinetics
metabolism
liver
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