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科研机构
上海药物研究所 [14]
内容类型
期刊论文 [14]
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2015 [1]
2014 [3]
2013 [2]
2012 [4]
2008 [2]
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专题:上海药物研究所
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Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets
期刊论文
SCIENTIFIC REPORTS, 2015, 卷号: 5
作者:
Lu, Junyan
;
Zeng, Hanlin
;
Liang, Zhongjie
;
Chen, Limin
;
Zhang, Liyi
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
Molecular-Dynamics-Simulation-Driven Design of a Protease-Responsive Probe for In-Vivo Tumor Imaging
期刊论文
ADVANCED MATERIALS, 2014, 卷号: 26, 期号: 48, 页码: 8174-8178
作者:
Jiang, Yifan
;
Lu, Junyan
;
Wang, Yaping
;
Zeng, Feng
;
Wang, Huiyuan
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 86, 页码: 242-256
作者:
Ji, Xun
;
Xia, Chunmei
;
Wang, Jiang
;
Su, Mingbo
;
Zhang, Lei
收藏
  |  
浏览/下载:97/0
  |  
提交时间:2019/01/08
DPP4 inhibitors
GLP-1
Selectivity
Oral bioavailability
Oral glucose tolerance tests
hERG
Design, synthesis and biological evaluation of hetero-aromatic moieties substituted pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 75, 页码: 111-122
作者:
Ji, Xun
;
Su, Mingbo
;
Wang, Jiang
;
Deng, Guanghui
;
Deng, Sisi
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2019/01/08
DPP4 inhibitors
Selectivity
Reversible kinetic characterization
Oral bioavailability
Oral glucose tolerance test
Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 24, 页码: 7988-7998
作者:
Zhang, Xu
;
Peng, Ting
;
Ji, Xun
;
Li, Jian
;
Tong, Linjiang
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
EGFR inhibitor
EGFR T790M/L858R
Binding mode
Irreversible EGFR inhibitor
Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D-1, D-2 and serotonin 5-HT1A multi-action profile
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 4, 页码: 856-868
作者:
Sun, Haifeng
;
Zhu, Liyuan
;
Yang, Huicui
;
Qian, Wangke
;
Guo, Lin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
Asymmetric synthesis
Tetrahydroprotoberberines
Dopamine receptors
Serotonin receptors
Multi-action
New pharmacological profile
Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: Selective inhibitors of dopamine D-1 receptor
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 卷号: 20, 期号: 15, 页码: 4862-4871
作者:
Qian, Wangke
;
Lu, Weijian
;
Sun, Haifeng
;
Li, Zeng
;
Zhu, Liyuan
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
Tetrahydroprotoberberine
Dopamine receptor
Anti-substance abuse
Antagonist
Enantioselective drug-protein interaction between mexiletine and plasma protein
期刊论文
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2012, 卷号: 64, 期号: 6, 页码: 792-801
作者:
Yu, Lushan
;
Hong, Yanjun
;
Li, Li
;
Jin, Yingxiu
;
Zheng, Mingyue
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
a1-acid glycoprotein
enantioselectivity
human serum albumin
mexiletine
molecular dynamics
Development of a novel class of B-Raf(V600E)-selective inhibitors through virtual screening and hierarchical hit optimization
期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, 卷号: 10, 期号: 36, 页码: 7402-7417
作者:
Kong, Xiangqian
;
Qin, Jie
;
Li, Zeng
;
Vultur, Adina
;
Tong, Linjiang
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Advances in the development of subtype-selective ligands of dopamine receptors
期刊论文
Chinese Journal of Medicinal Chemistry, 2012, 卷号: 22, 期号: 6, 页码: 516-532
作者:
Qian Wangke
;
Sun Haifeng
;
Li Zeng
;
Zhou Shengbin
;
Jiang Hualiang
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
dopamine
dopaminergic system
ligand
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