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科研机构
上海药物研究所 [22]
内容类型
期刊论文 [22]
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2018 [2]
2017 [1]
2016 [1]
2015 [1]
2014 [2]
2013 [3]
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Self-assembly of Fluorescent Dehydroberberine Enhances Mitochondria-Dependent Antitumor Efficacy
期刊论文
CHEMISTRY-A EUROPEAN JOURNAL, 2018, 卷号: 24, 期号: 39, 页码: 9812-9819
作者:
An, Ruibing
;
Gu, Zhanni
;
Sun, Haifeng
;
Hu, Yuxuan
;
Yan, Runqi
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
antitumor
cell imaging
dehydroberberine
mitochondria
self-assembly
Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes
期刊论文
BRAIN, 2018, 卷号: 141, 页码: 1782-1798
作者:
Song, Haikun
;
Li, Hexuan
;
Guo, Shimeng
;
Pan, Yuyin
;
Fu, Yuhua
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2019/01/08
GPCR
target validation
polyQ
neurodegeneration
antagonists
Design, synthesis and. biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5 '-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 140, 页码: 448-464
作者:
Zhou, Shengbin
;
Duan, Yanan
;
Wang, Jiang
;
Zhang, Jin
;
Sun, Haifeng
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
Tetrahydroberberine
4,7,12,12a-tetrahydro-5H-thieno[3 ',2 ':3,4]pyrido[1,2-b]isoquinolines
Mitochondrial respiration
AMPK indirect activators
db/db mice
Design, Synthesis, and Biological Evaluation of Novel Tetrahydroprotoberberine Derivatives (THPBs) as Selective alpha(1A)-Adrenoceptor Antagonists
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 20, 页码: 9489-9502
作者:
Guo, Diliang
;
Li, Jing
;
Lin, Henry
;
Zhou, Yu
;
Chen, Ying
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
Structural insight into substrate preference for TET- mediated oxidation
期刊论文
NATURE, 2015, 卷号: 527, 期号: 7576, 页码: 118-122
作者:
Hu, Lulu
;
Lu, Junyan
;
Cheng, Jingdong
;
Rao, Qinhui
;
Li, Ze
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
Design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel l-SPD derivatives possessing dopamine D-1, D-2 and serotonin 5-HT1A multiple action profiles
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 21, 页码: 5838-5846
作者:
Li, Zeng
;
Huang, Jiye
;
Sun, Haifeng
;
Zhou, Shengbin
;
Guo, Lin
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
l-SPD
Tetrahydroprotoberberine
Dopamine receptor
Serotonin receptor
Multiple action
One-pot metal-free synthesis of highly substituted pyrroles from 2-acetyl-3-methylene-1,4-dicarbonyl compounds and primary amines via TBHP and activated carbon oxidative aromatization of dihydropyrrole
期刊论文
RSC ADVANCES, 2014, 卷号: 4, 期号: 29, 页码: 15007-15010
作者:
Yang, Wei
;
Zhou, Yu
;
Sun, Haifeng
;
Zhang, Lei
;
Zhao, Fei
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands
期刊论文
CELL RESEARCH, 2013, 卷号: 23, 期号: 9, 页码: 1106-1118
作者:
Li, Ping
;
Chen, Zhuxi
;
Xu, Haiyan
;
Sun, Haifeng
;
Li, Hao
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
voltage-gated potassium channel
gating charge pathway
KCNQ2 activator
binding site
anti-epilepsy drug
Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D-1, D-2 and serotonin 5-HT1A multi-action profile
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 4, 页码: 856-868
作者:
Sun, Haifeng
;
Zhu, Liyuan
;
Yang, Huicui
;
Qian, Wangke
;
Guo, Lin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
Asymmetric synthesis
Tetrahydroprotoberberines
Dopamine receptors
Serotonin receptors
Multi-action
New pharmacological profile
Application of methyl in drug design
期刊论文
Acta Pharmaceutica Sinica, 2013, 卷号: 48, 期号: 8, 页码: 1195-1208
作者:
Lian Jie
;
Wang Jiang
;
Sun Haifeng
;
Lin Daizong
;
Liu Hong
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
methyl
drug design
lead optimization
stereoelectronic effect
liposolubility
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