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科研机构
上海药物研究所 [29]
内容类型
期刊论文 [29]
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2021 [4]
2020 [6]
2019 [4]
2017 [2]
2016 [4]
2015 [1]
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Discovery of chiral N-2 '-aryletheryl-1 '-alkoxy-ethyl substituted arylisoquinolones with anti-inflammatory activity from the nucleophilic addition reactions of the thiophenols and oxazolinium
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 11
作者:
Li, Bo
;
Li, Heng
;
Zhu, Zhengdan
;
Xiang, Caigui
;
Xu, Zhijian
收藏
  |  
浏览/下载:99/0
  |  
提交时间:2021/11/04
Anti-inflammatory activity
TNF alpha
ER beta
IBD Arylisoquinolones
A novel phosphoramide compound, DCZ0805, shows potent anti-myeloma activity via the NF-κB pathway
期刊论文
Cancer Cell International, 2021, 卷号: 21, 期号: 1
作者:
Gao,Xuejie
;
Li,Bo
;
Ye,Anqi
;
Wang,Houcai
;
Xie,Yongsheng
收藏
  |  
浏览/下载:97/0
  |  
提交时间:2021/06/11
Multiple myeloma
Anti-tumor activity
NF-κB
A novel phosphoramide compound, DCZ0805, shows potent anti-myeloma activity via the NF-kappa B pathway
期刊论文
CANCER CELL INTERNATIONAL, 2021, 卷号: 21, 期号: 1, 页码: 10
作者:
Gao, Xuejie
;
Li, Bo
;
Ye, Anqi
;
Wang, Houcai
;
Xie, Yongsheng
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/08/17
Multiple myeloma
Anti-tumor activity
NF-kappa B
A novel silicone derivative of natural osalmid (DCZ0858) exerts anti-multiple myeloma activity by promoting cell apoptosis and inhibiting cell cycle and mTOR signaling
期刊论文
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2021, 卷号: 13, 期号: 10, 页码: 11439-11449
作者:
Bu, Wenxuan
;
Li, Bo
;
Feng, Lijin
;
Feng, Qilin
;
Hu, Ke
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/12/16
Multiple myeloma
DCZ0858
mTOR
bone marrow microenvironment
cell proliferation
cell apoptosis
A novel M phase blocker, DCZ3301 enhances the sensitivity of bortezomib in resistant multiple myeloma through DNA damage and mitotic catastrophe
期刊论文
Journal of Experimental & Clinical Cancer Research, 2020, 卷号: 39, 期号: 1
作者:
Hu,Liangning
;
Li,Bo
;
Chen,Gege
;
Song,Dongliang
;
Xu,Zhijian
收藏
  |  
浏览/下载:94/0
  |  
提交时间:2020/07/01
Multiple myeloma
Drug-resistance
DNA damage response
Cell cycle
Alopecines A-E, five chloro-containing matrine-type alkaloids with immunosuppressive activities from the seeds of Sophora alopecuroides
期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 99, 页码: 5
作者:
Wang, Xiao-Feng
;
Zhu, Zhengdan
;
Hao, Ting-Ting
;
Fang, Qiang-Qiang
;
Jiang, Kun
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
Sophora alopecuroides
Alkaloids
Cl-containing matrines
Absolute configuration
Immunosuppressive activity
A novel phosphoramide compound, DCZ0847, displays in vitro and in vivo anti-myeloma activity, alone or in combination with bortezomib
期刊论文
CANCER LETTERS, 2020, 卷号: 478, 页码: 45-55
作者:
Chen, Gege
;
Hu, Ke
;
Sun, Haiguo
;
Zhou, Jinfeng
;
Song, Dongliang
收藏
  |  
浏览/下载:97/0
  |  
提交时间:2020/07/01
Multiple myeloma
Bone marrow microenvironment
DNA damage
JAK2/STAT3 pathway
A novel silicone derivative of natural osalmid (DCZ0858) induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma via the JAK2/STAT3 pathway
期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 卷号: 5, 期号: 1, 页码: 11
作者:
Lu, Kang
;
Li, Bo
;
Zhang, Hui
;
Xu, Zhijian
;
Song, Dongliang
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2020/07/01
Antitumor effects of rafoxanide in diffuse large B cell lymphoma via the PTEN/PI3K/Akt and JNK/c-Jun pathways
期刊论文
LIFE SCIENCES, 2020, 卷号: 243, 页码: 11
作者:
He, Wan
;
Xu, Zhijian
;
Song, Dongliang
;
Zhang, Hui
;
Li, Bo
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2020/07/01
Diffuse large B-cell lymphoma
Rafoxanide
PTEN/PI3K/AKT
Apoptosis
DNA damage
Glycolysis is suppressed by DCZ0801-induced inactivation of the Akt/mTOR pathway in Multiple Myeloma
期刊论文
JOURNAL OF CANCER, 2020, 卷号: 11, 期号: 16, 页码: 4907-4916
作者:
Feng, Qilin
;
Yao, Qingchun
;
Li, Bo
;
Xie, Yongsheng
;
Zhang, Hui
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/12/24
DCZ0801
multiple myeloma
apoptosis
cell cycle
glycolysis
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