CORC

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CORC

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Repressing MYC by targeting BET synergizes with selective inhibition of PI3K alpha against B cell lymphoma 期刊论文
CANCER LETTERS, 2022, 卷号: 524, 页码: 206-218
作者:  Chen, Zi-qi;  Cao, Zhe-rui;  Wang, Yi;  Zhang, Xi;  Xu, Lan
收藏  |  浏览/下载：53/0  |  提交时间：2021/12/16
CYH33  MYC  P300  BET  B cell lymphoma  PI3K  
Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity 期刊论文
ISCIENCE, 2021, 卷号: 24, 期号: 11, 页码: 22
作者:  Hu, Lin;  Chen, Fuxian;  Wu, Chao;  Wang, Jun;  Chen, Si-si
收藏  |  浏览/下载：38/0  |  提交时间：2022/01/18
Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function 期刊论文
CELL RESEARCH, 2021, 页码: 18
作者:  Xu, Xiang;  Ding, Guangjin;  Liu, Caizhi;  Ding, Yuhan;  Chen, Xiaoxin
收藏  |  浏览/下载：63/0  |  提交时间：2021/11/04
SAF-248, a novel PI3K delta-selective inhibitor, potently suppresses the growth of diffuse large B-cell lymphoma 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:  Zhang, Xi;  Duan, Yu-ting;  Wang, Yi;  Zhao, Xing-dong;  Sun, Yi-ming
收藏  |  浏览/下载：37/0  |  提交时间：2021/05/24
Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 31, 页码: 4
作者:  Xiang, Hao-Yue;  Chen, Jian-Yang;  Huan, Xia-Juan;  Chen, Yi;  Gao, Zhao-bing
收藏  |  浏览/下载：14/0  |  提交时间：2021/05/24
Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 10
作者:  Xiang, Hao-Yue;  Wang, Xiang;  Chen, Yan-Hong;  Zhang, Xi;  Tan, Cun
收藏  |  浏览/下载：34/0  |  提交时间：2021/05/24
Simultaneous inhibition of PI3K alpha and CDK4/6 synergistically suppresses Kras-mutated non-small cell lung cancer 期刊论文
MOLECULAR CANCER RESEARCH, 2020, 卷号: 18, 期号: 10, 页码: 44-45
作者:  Wang, Yu-xiang;  Li, Xian;  Liu, Xue-ling;  Wang, Bo-bo;  Chen, Yi
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/01
Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo [2,1-f] [1,2,4] triazine derivatives 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 12, 页码: 4
作者:  Xiang, Hao-Yue;  Chen, Yan-Hong;  Wang, Yi;  Zhang, Xi;  Ding, Jian
收藏  |  浏览/下载：38/0  |  提交时间：2020/07/01
Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses 期刊论文
CELL DISCOVERY, 2019, 卷号: 5, 页码: 15
作者:  Chen, Jinhuan;  Ye, Xiaohua;  Zhang, Xue-Yang;  Zhu, Zhengdan;  Zhang, Xiang
收藏  |  浏览/下载：31/0  |  提交时间：2020/07/01
Discovery of clinical candidate methyl (5-(6-((4(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) : A highly potent and selective PI3K alpha inhibitor for the treatment of advanced solid tumors 期刊论文
CANCER RESEARCH, 2018, 卷号: 78, 期号: 13, 页码: 2
作者:  Xiang, Haoyue;  Wang, Xiang;  Chen, Yanhong;  Zhang, Xi;  Chen, Yi
收藏  |  浏览/下载：2/0  |  提交时间：2020/07/01

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