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浏览/检索结果: 共7条，第1-7条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Liquid chromatography-mass spectrometry method for the quantification of an anti-sclerostin monoclonal antibody in cynomolgus monkey serum 期刊论文 JOURNAL OF PHARMACEUTICAL ANALYSIS, 2021, 卷号: 11, 期号: 4, 页码: 472-479 作者:  Gao, Yuxiong;  Chen, Zhendong;  Yang, Changyong;  Zhong, Dafang 收藏  |  浏览/下载：32/0  |  提交时间：2021/11/04 Anti-sclerostin monoclonal antibody (SHR-1222)  LC-MS/MS  Anti-drug antibody  Toxicokinetic   Two validated liquid chromatography-mass spectrometry methods with different pretreatments for the quantification of an anti-CD47 monoclonal antibody in rat and cynomolgus monkey serum compared with an electrochemiluminescence method 期刊论文 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 175, 页码: 11 作者:  Gao, Yuxiong;  Zhang, Dan;  Yang, Changyong;  Duan, Xiaotao;  Li, Xiuli 收藏  |  浏览/下载：11/0  |  提交时间：2020/07/01 Anti-CD47 monoclonal antibody  LC-MS  Adsorption issue  Electrochemiluminescence  Pharmacokinetics  Cross-validation   Pharmacologic characterization of fluzoparib, a novel poly(ADP-ribose) polymerase inhibitor undergoing clinical trials 期刊论文 CANCER SCIENCE, 2019, 卷号: 110, 期号: 3, 页码: 1064-1075 作者:  Wang, Lei;  Yang, Changyong;  Xie, Chengying;  Jiang, Jiahua;  Gao, Mingzhao 收藏  |  浏览/下载：22/0  |  提交时间：2020/07/01 antitumor activity  fluzoparib  pharmacokinetics  poly(ADP-ribose) polymerase  toxicity   shra1403anovelcmetantibodydrugconjugateexertsencouragingantitumoractivityincmetoverexpressingmodels 期刊论文 actapharmacologicasinica, 2019, 卷号: 40, 期号: 7, 页码: 971 作者:  Yang Changyong;  Wang Lei;  Sun Xing;  Tang Mi;  Quan Haitian 收藏  |  浏览/下载：10/0  |  提交时间：2020/07/01 SHR-A1403  c-Met ADC  anti-tumor  patient-derived xenograft (PDX)  molecular mechanisms   A bridging immunogenicity assay for monoclonal antibody: case study with SHR-1222 期刊论文 BIOANALYSIS, 2018, 卷号: 10, 期号: 14, 页码: 1115-1127 作者:  Zhang, Dan;  Yang, Changyong;  Chen, Xiaoyan;  Li, Xiuli;  Zhong, Dafang 收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 ADAs  anti-drug antibodies  bridging immunogenicity assay  monoclonal antibody (mAb)  SHR-1222   Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer 期刊论文 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 110, 页码: 51-61 作者:  Li, Xin;  Yang, Changyong;  Wan, Hong;  Zhang, Ge;  Feng, Jun 收藏  |  浏览/下载：136/0  |  提交时间：2019/01/08 Pyrotinib  HER2-postive breast cancer  Irreversible EGFR/HER2 dual tyrosine kinase  inhibitor  Preclinical  Clinical  Safety  Drug metabolism   Metabolic characterization of pyrotinib in humans by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry 期刊论文 JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2016, 卷号: 1033, 页码: 117-127 作者:  Zhu, Yunting;  Li, Liang;  Zhang, Ge;  Wan, Hong;  Yang, Changyong 收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08 Pyrotinib  UPLC/Q-TOF MS  Metabolism  Human  CYP3A4  Drug-drug interaction