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The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression 期刊论文
NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 17
作者:  Li, Xinzhi;  Yuan, Bingchuan;  Lu, Min;  Wang, Yuqin;  Ding, Na
收藏  |  浏览/下载:37/0  |  提交时间:2022/01/18
Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine 期刊论文
JOURNAL OF MOLECULAR STRUCTURE, 2021, 卷号: 1241, 页码: 14
作者:  Zhou, Xian;  Feng, Xuexin;  Wang, Dachi;  Chen, Deheng;  Wu, Gaoxing
收藏  |  浏览/下载:85/0  |  提交时间:2021/08/17
Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 13, 页码: 9458-9483
作者:  Huang, Huoming;  Li, Xueping;  Xie, Peng;  Li, Xinwei;  Xu, XueJun
收藏  |  浏览/下载:29/0  |  提交时间:2021/08/17
Diversified strategy for the synthesis of DNA-encoded oxindole libraries 期刊论文
CHEMICAL SCIENCE, 2021, 卷号: 12, 期号: 8, 页码: 2841-2847
作者:  Wang, Xuan;  Liu, Jiaxiang;  Yan, Ziqin;  Liu, Xiaohong;  Liu, Sixiu
收藏  |  浏览/下载:23/0  |  提交时间:2021/05/24
Design, Synthesis, and Structure-Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective mu Opioid Receptor Agonists 期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 2, 页码: 285-299
作者:  Huang, Huoming;  Li, Xinwei;  Guo, Wei;  Zhu, Chen;  Qian, Yuanyuan
收藏  |  浏览/下载:26/0  |  提交时间:2021/05/24
Discovery of a Potent and Selective NF-kappa B-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 8, 页码: 4388-4407
作者:  Li, Zhiqiang;  Li, Xinzhi;  Su, Ming-Bo;  Gao, Li-Xin;  Zhou, Yu-Bo
收藏  |  浏览/下载:28/0  |  提交时间:2020/07/01
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxypheny1)-N-phenylpiperidine-1-carboxamide as novel potent analgesic 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 189, 页码: 14
作者:  Huang, Huoming;  Wang, Wenli;  Xu, Xuejun;  Zhu, Chen;  Wang, Yujun
收藏  |  浏览/下载:33/0  |  提交时间:2020/07/01
Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 24, 页码: 11054-11070
作者:  Xiao, Li;  Wang, Yujun;  Zhang, Mumei;  Wu, Weiwei;  Kong, Linghui
收藏  |  浏览/下载:92/0  |  提交时间:2020/07/01
Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 182, 页码: 21
作者:  Chen, Deheng;  Lu, Tian;  Yan, Ziqin;  Lu, Wenchao;  Lyu, Xilin
收藏  |  浏览/下载:28/0  |  提交时间:2020/07/01
Uncovering kappa-opioid receptor agonist-induced PAK1/2 phosphorylation by quantitative phosphoproteomics 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 516, 期号: 1, 页码: 320-326
作者:  Wu, Jianhong;  Jiang, Qinghui;  Zhu, Hongwen;  Zhou, Yanting;  Lu, Dayun
收藏  |  浏览/下载:41/0  |  提交时间:2020/07/01


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