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Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:
Wang, Z (Wang, Zhen)[ 1 ]
;
Jiang, XR (Jiang, Xiangrui)[ 1 ]
;
Zhang, XL (Zhang, Xianglei)[ 1,2 ]
;
Tian, GH (Tian, Guanghui)[ 3 ]
;
Yang, RL (Yang, Rulei)[ 3 ]
收藏
  |  
浏览/下载:138/0
  |  
提交时间:2019/06/28
Social Engagement and Elderly Health in China: Evidence from the China Health and Retirement Longitudinal Survey (CHARLS)
期刊论文
International journal of environmental research and public health, 2019, 卷号: 16
作者:
Liu Jin[1]
;
Rozelle Scott[2]
;
Xu Qing[3]
;
Yu Ning[4]
;
Zhou Tianshu[5]
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  |  
浏览/下载:44/0
  |  
提交时间:2019/04/22
2SRI
elderly health
healthy aging
loneliness
social engagement
Triterpenoids, megastigmanes and hydroxycinnamic acid derivatives from Anisomeles indica
期刊论文
Natural product research, 2019, 卷号: 33, 页码: 41-46
作者:
Liu Quan-Wen[1]
;
Chen Cai-Hua[2]
;
Wang Xiao-Feng[3]
;
Jiang Kun[4]
;
Qu Shi-Jin[5]
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/04/22
2α
3α
19α-trihydroxyurs-12
20(30)-dien-28-oic acid
Lamiaceae
hydroxycinnamic acids
megastigmanes
triterpenoids
Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis
期刊论文
EBioMedicine, 2019, 卷号: 41, 页码: 538-555
作者:
He Xiaojuan[1]
;
Liu Jin[2]
;
Liang Chao[3]
;
Badshah Shaikh Atik[4]
;
Zheng Kang[5]
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  |  
浏览/下载:34/0
  |  
提交时间:2019/04/22
Bone formation
Inflammation
Osteoblast
PLEKHO1
Rheumatoid arthritis
The modulation of terahertz photoconductivity in CVD grown n-doped monolayer MoS2 with gas adsorption
期刊论文
Journal of physics. Condensed matter : an Institute of Physics journal, 2019, 卷号: 31, 页码: 245001
作者:
Xing Xiao[1]
;
Zhao Litao[2]
;
Zhang Zeyu[3]
;
Lin Xian[4]
;
Yu Yang[5]
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  |  
浏览/下载:44/0
  |  
提交时间:2019/04/22
oxygen passivation
terahertz photoconductivity
transition metal dichalcogenides
trions
Fabrication of gadolinium zirconate films by laser CVD
期刊论文
CERAMICS INTERNATIONAL, 2019, 卷号: 45, 页码: 4926-4933
作者:
Yang, Guang[1]
;
Wang, Duojin[2]
;
Zhang, Chi[3]
;
Cao, Jin[4]
;
Du, Yaxiong[5]
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  |  
浏览/下载:31/0
  |  
提交时间:2019/04/22
Gadolinium zirconate
LCVD
Gd/Zr atomic ratio
One New Phenolic Compound from Castanea mollissima Shells and its Suppression of HepatomaCell Proliferation and Inflammation by Inhibiting NF-κB Pathway
期刊论文
International journal of molecular sciences, 2019, 卷号: 20
作者:
Fei Wu[1]
;
Xuan Yao[2]
;
Jian Xu[3]
;
Yue Wu[4]
;
Yuejun Yang[5]
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  |  
浏览/下载:61/0
  |  
提交时间:2019/04/22
Castanea mollissima shells
TLR4–NF-κB pathway
anti-inflammatory activities
anticancer activities
hepatoma cells
phenols
In vitro experimental and numerical study on biomechanics and stability of a novel adjustable hemipelvic prosthesis
期刊论文
Journal of the mechanical behavior of biomedical materials, 2019, 卷号: 90, 页码: 626-634
作者:
Liu Dongxu[1]
;
Jiang Jianfeng[2]
;
Wang Lei[3]
;
Liu Jie[4]
;
Jin Zhongmin[5]
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  |  
浏览/下载:13/0
  |  
提交时间:2019/04/22
Biomechanics
Finite element (FE) method
Pelvis
Prosthesis
Reconstruction stability
Prediction of ligand modulation patterns on membrane receptors via lysine reactivity profiling
期刊论文
Chemical communications (Cambridge, England), 2019
作者:
Zhou Ye[1]
;
Liu Zheyi[2]
;
Zhang Jinbao[3]
;
Dou Tongyi[4]
;
Chen Jin[5]
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  |  
浏览/下载:19/0
  |  
提交时间:2019/04/22
Integrated bioinformatics analysis of key genes involved in progress of colon cancer
期刊论文
Molecular genetics & genomic medicine, 2019, 页码: e588
作者:
Yang Haojie[1]
;
Wu Jiong[2]
;
Zhang Jingjing[3]
;
Yang Zhigang[4]
;
Jin Wei[5]
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/04/22
GEO
TCGA
bioinformatic analysis
colon cancer
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