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浏览/检索结果: 共49条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis 期刊论文 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6 作者:  Yang, Xiangbo;  Lu, Huimin;  Xie, Hang;  Zhang, Binbin;  Nie, Tianqing 收藏  |  浏览/下载：25/0  |  提交时间：2022/01/18 Binding studies  Drug discovery  Necroptosis  RIPK1 inhibitors  Sepsis   Acceptor engineering of small-molecule fluorophores for NIR-II fluorescence and photoacoustic imaging 期刊论文 JOURNAL OF MATERIALS CHEMISTRY B, 2021, 卷号: 9, 期号: 48, 页码: 9951-9960 作者:  Li, Yaxi;  Zhou, Hongli;  Bi, Renzhe;  Li, Xiuting;  Zha, Menglei 收藏  |  浏览/下载：38/0  |  提交时间：2022/01/04 Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation 期刊论文 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9 作者:  Liu, Xiao;  Yang, Su;  Hart, Jonathan R.;  Xu, Yingna;  Zou, Xinyu 收藏  |  浏览/下载：39/0  |  提交时间：2022/01/04 phosphoinositide 3-kinase (PI3K)  activation  inhibition  activity-dependent conformational changes   Concise synthesis of N-phosphorylated amides through three-component reactions 期刊论文 GREEN CHEMISTRY, 2021, 页码: 5 作者:  Zhu, Yuan-Yuan;  Zhang, Tao;  Zhou, Linlin;  Yang, Shang-Dong 收藏  |  浏览/下载：14/0  |  提交时间：2021/12/16 5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19 作者:  Wang, Shuni;  Yang, Hong;  Su, Mingbo;  Lian, Fulin;  Cong, Zhanqing 收藏  |  浏览/下载：80/0  |  提交时间：2021/11/04 NSD2  Methyltransferase  HTS  Multiple myeloma  5-Aminonaphthalene derivatives  Inhibitor   Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine 期刊论文 JOURNAL OF MOLECULAR STRUCTURE, 2021, 卷号: 1241, 页码: 14 作者:  Zhou, Xian;  Feng, Xuexin;  Wang, Dachi;  Chen, Deheng;  Wu, Gaoxing 收藏  |  浏览/下载：85/0  |  提交时间：2021/08/17 Chaetominine  Cellular growth inhibition  Cancer cell line  Covalent warhead   Constitutive signal bias mediated by the human GHRHR splice variant 1 期刊论文 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 40, 页码: 10 作者:  Cong, Zhaotong;  Zhou, Fulai;  Zhang, Chao;  Zou, Xinyu;  Zhang, Huibing 收藏  |  浏览/下载：26/0  |  提交时间：2021/12/01 class B1 GPCR  receptor bias  cancer  cell proliferation   Insights into agonist-elicited activation of the human glucose-dependent insulinotropic polypeptide receptor 期刊论文 BIOCHEMICAL PHARMACOLOGY, 2021, 卷号: 192, 页码: 16 作者:  Yuliantie, Elita;  van der Velden, Wijnand J. C.;  Labroska, Viktorija;  Dai, Antao;  Zhao, Fenghui 收藏  |  浏览/下载：44/0  |  提交时间：2021/11/04 Glucose-dependent insulinotropic polypeptide receptor  G protein-coupled receptor  GPCR structure-function relationship  ERK  cAMP  Arrestin   The Novel Chinese Medicine JY5 Formula Alleviates Hepatic Fibrosis by Inhibiting the Notch Signaling Pathway 期刊论文 FRONTIERS IN PHARMACOLOGY, 2021, 卷号: 12, 页码: 15 作者:  Fu, Yadong;  Xiao, Zhun;  Tian, Xiaoting;  Liu, Wei;  Xu, Zhou 收藏  |  浏览/下载：30/0  |  提交时间：2022/01/04 traditional Chinese medicine  JY5 formula  fuzheng huayu  hepatic fibrosis  notch signaling pathway   A validated HPLC-MS/MS method for determination of simmitecan and its metabolite chimmitecan in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor 期刊论文 JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 8 作者:  Zhou, Jun;  Zhan, Yan;  Zhong, Dafang;  Chen, Xiaoyan;  Zhang, Yifan 收藏  |  浏览/下载：72/0  |  提交时间：2021/11/04 chimmitecan  mass spectrometry  pharmacokinetics  simmitecan  solid tumors