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科研机构
上海药物研究所 [4]
金属研究所 [2]
内容类型
期刊论文 [6]
发表日期
2020 [6]
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Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 7
作者:
Bi, Xiaoyang
;
Chen, Yu
;
Sun, Zhongya
;
Lu, Wenchao
;
Xu, Pan
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Drug design
CBP
Bromodomain
Inhibitor
Acute myeloid leukemia
Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain
期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 101, 页码: 11
作者:
Chen, Yu
;
Bi, Xiaoyang
;
Zhang, Fengcai
;
Sun, Zhongya
;
Xu, Pan
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/12/24
In silico screening
Drug design
CBP
Bromodomain
Inhibitor
Acute Myeloblastic Leukemia
Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion
期刊论文
ADVANCED SCIENCE, 2020, 页码: 13
作者:
Sun, Zhongya
;
Zhang, Hao
;
Zhang, Yuanyuan
;
Liao, Liping
;
Zhou, Wen
收藏
  |  
浏览/下载:107/0
  |  
提交时间:2020/07/01
anti-metastasis activities
crystal structures
inhibitors
novel pockets
rho family proteins
A patent review of BRD4 inhibitors (2013-2019)
期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2020, 卷号: 30, 期号: 1, 页码: 57-81
作者:
Lu, Tian
;
Lu, Wenchao
;
Luo, Cheng
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
Bromodomain-containing protein 4 (BRD4)
bromodomain and extra-terminal (BET) family
small molecule inhibitors
cancer
patent
therapeutic potential
Effect of Post-weld Tempering on the Microstructure and Mechanical Properties in the Simulated HAZs of a High-Strength-High-Toughness Combination Marine Engineering Steel
期刊论文
金属学报:英文版, 2020, 卷号: 000, 期号: 003, 页码: 391-402
作者:
WenChao Dong
;
MingYue Wen
;
HuiYong Pang
;
ShanPing Lu
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/02/02
High-strength-high-toughness
combination
steel
Post-weld
heat
treatment
Heat-affected
zones(HAZs)
Carbides
Impact
toughness
Effect of Post-weld Tempering on the Microstructure and Mechanical Properties in the Simulated HAZs of a High-Strength-High-Toughness Combination Marine Engineering Steel
期刊论文
金属学报:英文版, 2020, 卷号: 000, 期号: 003, 页码: 391-402
作者:
WenChao Dong
;
MingYue Wen
;
HuiYong Pang
;
ShanPing Lu
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/02/02
High-strength-high-toughness
combination
steel
Post-weld
heat
treatment
Heat-affected
zones(HAZs)
Carbides
Impact
toughness
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