QQ客服 官方微博 反馈留言

浏览/检索结果: 共5条，第1-5条 帮助 限定条件 发表日期：2017     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer 期刊论文 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 110, 页码: 51-61 作者:  Li, Xin;  Yang, Changyong;  Wan, Hong;  Zhang, Ge;  Feng, Jun 收藏  |  浏览/下载：136/0  |  提交时间：2019/01/08 Pyrotinib  HER2-postive breast cancer  Irreversible EGFR/HER2 dual tyrosine kinase  inhibitor  Preclinical  Clinical  Safety  Drug metabolism   Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of rapamycin 期刊论文 ONCOTARGET, 2017, 卷号: 8, 期号: 64, 页码: 107977-107990 作者:  Xie, Chengying;  Chen, Xiangling;  Zheng, Mingyue;  Liu, Xiaohong;  Wang, Hongbin 收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 BEZ235  drug resistance  mTOR  PI3K  SHR8443   AKT is critically involved in the antagonism of BRAF inhibitor sorafenib against dabrafenib in colorectal cancer cells harboring both wild-type and mutant (V600E) BRAF genes 期刊论文 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 卷号: 489, 期号: 1, 页码: 14-20 作者:  Wang, Hongbin;  Quan, Haitian;  Lou, Liguang 收藏  |  浏览/下载：25/0  |  提交时间：2019/01/08 Antagonism  AKT  BRAF  Dabrafenib  Sorafenib   Aberrant intracellular metabolism of T-DM1 confers T-DM1 resistance in human epidermal growth factor receptor 2-positive gastric cancer cells 期刊论文 CANCER SCIENCE, 2017, 卷号: 108, 期号: 7, 页码: 1458-1468 作者:  Wang, Hongbin;  Wang, Wenqian;  Xu, Yongping;  Yang, Yong;  Chen, Xiaoyan 收藏  |  浏览/下载：31/0  |  提交时间：2019/01/08 Antibody-drug conjugate  drug resistance  HER2  T-DM1  V-ATPase   Puquitinib, a novel orally available PI3K inhibitor, exhibits potent antitumor efficacy against acute myeloid leukemia 期刊论文 CANCER SCIENCE, 2017, 卷号: 108, 期号: 7, 页码: 1476-1484 作者:  Xie, Chengying;  He, Ye;  Zhen, Mingyue;  Wang, Yulan;  Xu, Yongping 收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08 Acute myeloid leukemia  CAL-101  PI3K signaling  PI3K  puquitinib