QQ客服 官方微博 反馈留言

浏览/检索结果: 共12条，第1-10条 帮助 限定条件 发表日期：2017    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Preparation of 5 '-deoxy-5 '-amino-5 '-C-methyl adenosine derivatives and their activity against DOT1L 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 22, 页码: 4960-4963 作者:  Liu, Tongchao;  Xie, Wuchen;  Li, Cong;  Ren, Huanming;  Mao, Yudong 收藏  |  浏览/下载：22/0  |  提交时间：2019/01/08 5'-Deoxy-5'-amino-5'-C-methyl adenosine derivative  N-glycosylation  Nucleoside synthesis  DOT1L inhibitor  Structure activity relationship   Honokiol inhibits bladder cancer cell invasion through repressing SRC-3 expression and epithelial-mesenchymal transition 期刊论文 ONCOLOGY LETTERS, 2017, 卷号: 14, 期号: 4, 页码: 4294-4300 作者:  Shen, Lan;  Zhang, Fang;  Huang, Ruimin;  Yan, Jun;  Shen, Bing 收藏  |  浏览/下载：25/0  |  提交时间：2019/01/08 honokiol  bladder cancer  cell invasion  steroid receptor coactivator-3  epithelial-mesenchymal transition  Twist1   Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 176-195 作者:  Hu, Jianping;  Wang, Yingqing;  Li, Yanlian;  Xu, Lin;  Cao, Danyan 收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 BRD4 inhibitor  Kinase  BI-2536  Dihydroquinoxalin-2(1H)-one   Design and optimization of purine derivatives as in vivo active PDE10A inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 卷号: 25, 期号: 13, 页码: 3315-3329 作者:  Chen, Liu;  Chen, Danqi;  Tang, Le;  Ren, Jing;  Chen, Jiaojiao 收藏  |  浏览/下载：31/0  |  提交时间：2019/01/08 Phosphodiesterase  PDE10A  Purine  Inhibitor  Anti-psychotic   Activation of D1R/PKA/mTOR signaling cascade in medial prefrontal cortex underlying the antidepressant effects of l-SPD 期刊论文 SCIENTIFIC REPORTS, 2017, 卷号: 7 作者:  Zhang, Bing;  Guo, Fei;  Ma, Yuqin;  Song, Yingcai;  Lin, Rong 收藏  |  浏览/下载：25/0  |  提交时间：2019/01/08 Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 11, 页码: 4680-4692 作者:  Qu, Chunrong;  Ding, Mingmin;  Zhu, Yingmin;  Lu, Yungang;  Du, Juan 收藏  |  浏览/下载：89/0  |  提交时间：2019/01/08 Stereoselective addition of Grignard reagents to (2-methyl-5-tert-butyl)phenyl 1-thio-beta-D-ribopentodialdo-1,4-furanoside derivative 期刊论文 TETRAHEDRON, 2017, 卷号: 73, 期号: 16, 页码: 2290-2304 作者:  Ren, Huanming;  Xie, Wuchen;  Xiong, Bing;  Shen, Jingkang;  Chen, Guohua 收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08 Nucleophilic addition  Stereoselective reaction  Grignard reagents  5-C-Substituted ribofuranoside  Mosher ester   Discovery and Biological Evaluation of a Series of Pyrrolo[2,3-b]pyrazines as Novel FGFR Inhibitors 期刊论文 MOLECULES, 2017, 卷号: 22, 期号: 4 作者:  Zhang, Yan;  Liu, Hongchun;  Zhang, Zhen;  Wang, Ruifeng;  Liu, Tongchao 收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08 FGFR1  inhibitor  kinase inhibitor  pyrazine  hinge binder   A Strategy Combining Higher Energy C-Trap Dissociation with Neutral Loss- and Product Ion-Based MSn Acquisition for Global Profiling and Structure Annotation of Fatty Acids Conjugates 期刊论文 JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2017, 卷号: 28, 期号: 3, 页码: 443-451 作者:  Bi, Qi-rui;  Hou, Jin-jun;  Yang, Min;  Shen, Yao;  Qi, Peng 收藏  |  浏览/下载：37/0  |  提交时间：2019/01/08 Neutral loss based Ms-3 acquisition  Product ion based Ms-4 acquisition  Fatty acid conjugates  Venenum bufonis  Higher-energy C-trap dissociation  Linear ion-trap quadrupole Orbitrap mass spectrometry   Novel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution 期刊论文 ONCOTARGET, 2017, 卷号: 8, 期号: 3, 页码: 4156-4168 作者:  He, Jin-Xue;  Wang, Meng;  Huan, Xia-Juan;  Chen, Chuan-Huizi;  Song, Shan-Shan 收藏  |  浏览/下载：35/0  |  提交时间：2019/01/08 MPH  PARP inhibitor  homologous recombination  antitumor activity  synthetic lethality