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科研机构
山东大学 [20]
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期刊论文 [19]
会议论文 [1]
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2019 [3]
2018 [2]
2017 [1]
2016 [2]
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专题:山东大学
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Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing
期刊论文
European Journal of Medicinal Chemistry, 2019, 卷号: 182
作者:
Zhao T.
;
Meng Q.
;
Kang D.
;
Ji J.
;
De Clercq E.
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
Antiviral activity
Chemical space
Drug design
Indolylarylsulfones
Molecular modeling
NNRTIs
SAR
Gastric-acid-mediated drug-drug interactions with direct-acting antiviral medications for hepatitis C virus infection: clinical relevance and mitigation strategies
期刊论文
DRUG DISCOVERY TODAY, 2019, 卷号: 24, 期号: 3, 页码: 845-857
作者:
Yu, Guo
;
Zheng, Yi
;
Yu, Yichao
;
Li, Guo-Fu
;
Derendorf, Hartmut
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/11
Small molecule inhibits respiratory syncytial virus entry and infection by blocking the interaction of the viral fusion protein with the cell membrane
期刊论文
FASEB JOURNAL, 2019, 卷号: 33, 期号: 3, 页码: 4287-4299
作者:
Tang, Wei
;
Li, Manmei
;
Liu, Yujun
;
Liang, Ning
;
Yang, Zhu
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/11
RSV
viral entry
antiviral
mice
drug resistance
Update on Recent Developments in Small Molecular HIV-1 RNase H Inhibitors (2013-2016): Opportunities and Challenges
期刊论文
CURRENT MEDICINAL CHEMISTRY, 2018, 卷号: 25, 期号: 14, 页码: 1682-1702
作者:
Wang, Xueshun
;
Gao, Ping
;
Menendez-Arias, Luis
;
Liu, Xinyong
;
Zhan, Peng
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/11
AIDS
HIV-1
RNase H inhibitors
dual inhibitors
drug design
SAR
antiviral
metalloenzyme
Design, synthesis, and antiviral evaluation of novel hydrazone-substituted thiophene[3,2-d]pyrimidine derivatives as potent human immunodeficiency virus-1 inhibitors
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 卷号: 92, 期号: 6, 页码: 2009-2021
作者:
Wang, Zhao
;
Kang, Dongwei
;
Chen, Meng
;
Wu, Gaochan
;
Feng, Da
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/11
backbone-binding
diarylpyrimidine
HIV-1
molecular simulation
NNRTIs
thiophene[3,2-d]pyrimidine
Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 126, 页码: 190-201
作者:
Li, Xiao
;
Gao, Ping
;
Huang, Boshi
;
Zhou, Zhongxia
;
Yu, Zhao
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
HIV
NNRTIs
Indolylarylsulfones
Antiviral activity
SAR
Molecular
modeling
Chemical space
Drug design
Synthesis of Pyrazine-1,3-thiazine Hybrid Analogues as Antiviral Agent Against HIV-1, Influenza A (H1N1), Enterovirus 71 (EV71), and Coxsackievirus B3 (CVB3)
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2016, 卷号: 88, 期号: 3, 页码: 411-421
作者:
Wu, Hong-Min
;
Zhou, Kuo
;
Wu, Tao
;
Cao, Yin-Guang
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/16
antiviral activity
coxsackievirus B3
enterovirus 71 (EV71)
H1N1
HIV-1
synthesis
Arylazolyl(azinyl)thioacetanilides: Part 19: Discovery of Novel Substituted Imidazo[4,5-b]pyridin-2-ylthioacetanilides as Potent HIV NNRTIs Via a Structure-based Bioisosterism Approach
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2016, 卷号: 88, 期号: 2, 页码: 241-253
作者:
Li, Xiao
;
Huang, Boshi
;
Zhou, Zhongxia
;
Gao, Ping
;
Pannecouque, Christophe
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/17
antiviral activity
drug design
HIV
imidazo[4,5-b]pyridin-2-ylthioacetanilides
molecular modeling
NNRTIs
SAR
Design, Synthesis, and Anti-HIV Evaluation of Novel Triazine Derivatives Targeting the Entrance Channel of the NNRTI Binding Pocket
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2015, 卷号: 86, 期号: 1, 页码: 122-128
作者:
Chen, Xuwang
;
Meng, Qing
;
Qiu, Liyun
;
Zhan, Peng
;
Liu, Huiqing
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/17
antiviral activity
entrance channel
HIV-1
molecular modeling
NNRTIs
Synthesis and Preliminary Antiviral Activities of Piperidine-substituted Purines against HIV and Influenza A/H1N1 Infections
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2015, 卷号: 86, 期号: 4, 页码: 568-577
作者:
Kang, Dongwei
;
Fang, Zengjun
;
Huang, Boshi
;
Zhang, Lingzi
;
Liu, Huiqing
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/17
bioactivity
heterocycle
HIV
influenza virus
NNRTIs
structure-activity relationship
synthesis
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