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科研机构
上海药物研究所 [173]
内容类型
期刊论文 [173]
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2021 [22]
2020 [20]
2019 [7]
2018 [26]
2017 [21]
2016 [13]
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Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6
作者:
Yang, Xiangbo
;
Lu, Huimin
;
Xie, Hang
;
Zhang, Binbin
;
Nie, Tianqing
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/01/18
Binding studies
Drug discovery
Necroptosis
RIPK1 inhibitors
Sepsis
STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Wu, Bing
;
Xu, Meng-meng
;
Fan, Chen
;
Feng, Chun-lan
;
Lu, Qiu-kai
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2022/01/18
acute lung injury
STING
vascular endothelial cells
inflammatory cytokines
chemokines
chemotaxis
Theoretical study and application of 2-phenyl-1,3,4-thiadiazole derivatives with optical and inhibitory activity against SHP1
期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2021, 页码: 14
作者:
Zhang, Chun
;
Sun, Yi-Tao
;
Gao, Li-Xin
;
Feng, Bo
;
Yan, Xue
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/01/18
Advancing COVID-19 diagnosis with privacy-preserving collaboration in artificial intelligence
期刊论文
NATURE MACHINE INTELLIGENCE, 2021, 卷号: 3, 期号: 12, 页码: 1081-1089
作者:
Bai, Xiangd
;
Wang, Hanchen
;
Ma, Liya
;
Xu, Yongchao
;
Gan, Jiefeng
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2022/01/18
Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
期刊论文
ISCIENCE, 2021, 卷号: 24, 期号: 11, 页码: 22
作者:
Hu, Lin
;
Chen, Fuxian
;
Wu, Chao
;
Wang, Jun
;
Chen, Si-si
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2022/01/18
Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Zou, Hui-xi
;
Zhang, Yu-feng
;
Zhong, Da-fang
;
Jiang, Yong
;
Liu, Fei
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/01/04
furmonertinib
autoinduction
food effect
alkaline phosphatase
body weight
pharmacokinetics
modeling and simulation
NSCLC
Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation
期刊论文
JOURNAL OF ADVANCED RESEARCH, 2021, 卷号: 33, 页码: 241-251
作者:
Li, Heng
;
Zhang, Xianglei
;
Xiang, Caigui
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2021/11/04
PDE4
Arctigenin
Psoriasis
Inflammation
Rhodomeroterpene alleviates macrophage infiltration and the inflammatory response in renal tissue to improve acute kidney injury
期刊论文
FASEB JOURNAL, 2021, 卷号: 35, 期号: 11, 页码: 17
作者:
Wu, Yong-Mei
;
Shi, Qing
;
Zhu, Peng-Fei
;
Ma, Hai-Jian
;
Cui, Shi-Chao
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2021/12/16
acute kidney injury
IKK/NF-kappa B
inflammation
macrophage
PI3K/PDK1/Akt
rhodomeroterpene
GADD45 beta stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation
期刊论文
PHARMACOLOGICAL RESEARCH, 2021, 卷号: 173, 页码: 11
作者:
Dong, Yunxia
;
Ma, Ningning
;
Fan, Lei
;
Yuan, Luyang
;
Wu, Qian
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2021/12/16
Non-alcoholic fatty liver disease
GADD45 beta
HSP72
Lipid accumulation
Insulin resistance
Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 卷号: 22, 期号: 20, 页码: 27
作者:
Cheng, Chen
;
Yu, Xuan
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/12/16
antiseptic actions
Chinese herbal medicines
material basis
Qingwen Baidu decoction
Shengfu injection
Shengmai
sepsis
Xuanbai Chengqi decoction
XueBiJing injection
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