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科研机构
上海药物研究所 [9]
内容类型
期刊论文 [9]
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2021 [1]
2020 [1]
2017 [1]
2015 [2]
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Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218, 页码: 14
作者:
Yang, Xiangbo
;
Wang, Zhijia
;
Pei, Yuan
;
Song, Ning
;
Xu, Lei
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/08/17
SHP2 degradation
Proteolysis targeting chimera (PROTAC)
Thalidomide-based heterobifunctional molecules
E3 ubiquitin ligase
CRBN
Isoform-resolved correlation analysis between mRNA abundance regulation and protein level degradation
期刊论文
MOLECULAR SYSTEMS BIOLOGY, 2020, 卷号: 16, 期号: 3, 页码: 19
作者:
Salovska, Barbora
;
Zhu, Hongwen
;
Gandhi, Tejas
;
Frank, Max
;
Li, Wenxue
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
alternative splicing
DIA mass spectrometry
protein turnover
proteomics
pulsed SILAC
Dihydroartemisinin selectively inhibits PDGFR alpha-positive ovarian cancer growth and metastasis through inducing degradation of PDGFR alpha protein
期刊论文
CELL DISCOVERY, 2017, 卷号: 3
作者:
Li, Xiaoguang
;
Ba, Qian
;
Liu, Yanling
;
Yue, Qingxi
;
Chen, Peizhan
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
Dihydroartemisinin
Epithelial-mesenchymal transition
metastasis
ovarian cancer
PDGFR alpha
Proteomic and bioinformatic analyses of possible target-related proteins of gambogic acid in human breast carcinoma MDA-MB-231 cells
期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2015, 卷号: 13, 期号: 1, 页码: 41-51
作者:
Li Dong
;
Song Xiao-Yi
;
Yue Qing-Xi
;
Cui Ya-Jun
;
Liu Miao
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
Gambogic acid
MDA-MB-231 cells
Anti-cancer
Proteomic
Bioinformatic
Proteomic and bioinformatic analyses of possible targetrelated proteins of gambogic acid in human breast carcinoma MDA-MB-231 cells
期刊论文
Chinese Journal of Natural Medicines, 2015, 卷号: 13, 期号: 1, 页码: 41
作者:
Li Dong
;
Song Xiaoyi
;
Yue Qingxi
;
Cui Yajun
;
Liu Miao
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
INDUCED APOPTOSIS
INHIBITS ANGIOGENESIS
UP-REGULATION
CYCLE ARREST
CANCER-CELLS
PHOSPHORYLATION
ACCUMULATION
DEGRADATION
RESISTANCE
MECHANISM
Gambogic acid
MDA-MB-231 cells
Anti-cancer
Proteomic
Bioinformatic
An Arginine-rich Motif of Ring Finger Protein 4 (RNF4) Oversees the Recruitment and Degradation of the Phosphorylated and SUMOylated Kruppel-associated Box Domain-associated Protein 1 (KAP1)/TRIM28 Protein during Genotoxic Stress
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 卷号: 289, 期号: 30, 页码: 20757-20772
作者:
Kuo, Ching-Ying
;
Li, Xu
;
Kong, Xiang-Qian
;
Luo, Cheng
;
Chang, Che-Chang
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
MCL-1 Degradation Mediated by JNK Activation via MEKK1/TAK1-MKK4 Contributes to Anticancer Activity of New Tubulin Inhibitor MT189
期刊论文
MOLECULAR CANCER THERAPEUTICS, 2014, 卷号: 13, 期号: 6, 页码: 1480-1491
作者:
Wang, Wei
;
Wang, Ying-Qing
;
Meng, Tao
;
Yi, Jun-Mei
;
Huan, Xia-Juan
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-κB signaling pathway
期刊论文
The Journal of pharmacology and experimental therapeutics, 2013, 卷号: 345, 期号: 3, 页码: 473-82
作者:
Dou, Wei
;
Zhang, Jingjing
;
Zhang, Eryun
;
Sun, Aning
;
Ding, Lili
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
A multifunctional nano device as non-viral vector for gene delivery: In vitro characteristics and transfection
期刊论文
JOURNAL OF CONTROLLED RELEASE, 2007, 卷号: 118, 期号: 3, 页码: 381-388
作者:
Gao, Yu
;
Gu, Wangwen
;
Chen, Lingli
;
Xu, Zhenghong
;
Li, Yaping
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
non-viral vector
pDNA
multifunctional nano device
folate
protamine
poly(cyanoacrylate)
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