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科研机构
上海药物研究所 [26]
内容类型
期刊论文 [25]
会议论文 [1]
发表日期
2021 [1]
2019 [1]
2018 [1]
2017 [8]
2016 [3]
2015 [2]
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Imatinib inhibits the malignancy of hepatocellular carcinoma by suppressing autophagy
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 卷号: 906, 页码: 8
作者:
Xiao, Meng-Chao
;
Qian, Hui
;
Huang, Chen-Kai
;
Zheng, Bai-Nan
;
Yan, Fang-Zhi
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2021/11/04
Imatinib
Autophagy
Hepatocarcinoma
Sorafenib
Synergetic effect
Exploring binding mechanisms of VEGFR2 with three drugs lenvatinib, sorafenib, and sunitinib by molecular dynamics simulation and free energy calculation
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 93, 期号: 5, 页码: 934-948
作者:
Wang, Yu
;
Peng, Cheng
;
Wang, Guimin
;
Xu, Zhijian
;
Luo, Yongfeng
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
hydrophobic contact scanning
MM
GBSA
molecular dynamics simulation
VEGFR2-drugs interaction
Pyrazolo[4,3-b]pyrimido[4,5-e][1,4]diazepine derivatives as new multi-targeted inhibitors of Aurora A/B and KDR
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 428-441
作者:
Zhang, Qiumeng
;
Shen, Qianqian
;
Gao, Lixin
;
Tong, Linjiang
;
Li, Jia
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
Aurora A
Aurora B
KDR
Multi-targeted
Anticancer
Heterocyclic
Hypoxia induces universal but differential drug resistance and impairs anticancer mechanisms of 5-fluorouracil in hepatoma cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 12, 页码: 1642-1654
作者:
Li, Jing-qiu
;
Wu, Xian
;
Gan, Lu
;
Yang, Xiang-liang
;
Miao, Ze-hong
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  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
hepatocellular carcinoma
hypoxia
5-fluorouracil
sorafenib
drug resistance
6-Methoxyethylamino-numonafide inhibits hepatocellular carcinoma xenograft growth as a single agent and in combination with sorafenib
期刊论文
FASEB JOURNAL, 2017, 卷号: 31, 期号: 12, 页码: 5453-5465
作者:
Liu, Yanning
;
Lou, Guohua
;
Norton, John T.
;
Wang, Chen
;
Kandela, Irawati
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  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
MEAN
HCC therapeutic
combination treatment
C-MYC inhibition
Mansouramycin C kills cancer cells through reactive oxygen species production mediated by opening of mitochondrial permeability transition pore
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 61, 页码: 104057-104071
作者:
Kuang, Shan
;
Liu, Ge
;
Cao, Ruobing
;
Zhang, Linlin
;
Yu, Qiang
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  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
mansouramycin C
marine-derived isoquinolinequinone
reactive oxygen species
mitochondrial permeability transition pore
anticancer drug
Aspirin disrupts the mTOR-Raptor complex and potentiates the anti-cancer activities of sorafenib via mTORC1 inhibition
期刊论文
CANCER LETTERS, 2017, 卷号: 406, 页码: 105-115
作者:
Sun, Danni
;
Liu, Hongchun
;
Dai, Xiaoyang
;
Zheng, Xingling
;
Yan, Juan
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  |  
浏览/下载:47/0
  |  
提交时间:2019/01/08
Aspirin
mTORC1
AMPK
Sorafenib
Proliferation
AKT is critically involved in the antagonism of BRAF inhibitor sorafenib against dabrafenib in colorectal cancer cells harboring both wild-type and mutant (V600E) BRAF genes
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 卷号: 489, 期号: 1, 页码: 14-20
作者:
Wang, Hongbin
;
Quan, Haitian
;
Lou, Liguang
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
Antagonism
AKT
BRAF
Dabrafenib
Sorafenib
Simultaneous determination of donafenib and its N-oxide metabolite in human plasma by liquid chromatography-tandem mass spectrometry
期刊论文
Acta Pharmaceutica Sinica, 2017, 卷号: 52, 期号: 3, 页码: 443-448
作者:
Wang Jing
;
Lu Binhua
;
Dai Xiaojian
;
Zhang Yifan
;
Chen Xiaoyan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
LC-MS/MS
LC-MS/MS
donafenib
sorafenib
N-oxide metabolite
Preclinical activity of DCZ3301, a novel aryl-guanidino compound in the therapy of multiple myeloma
期刊论文
THERANOSTICS, 2017, 卷号: 7, 期号: 15, 页码: 3690-3699
作者:
Gao, Minjie
;
Li, Bo
;
Sun, Xi
;
Zhou, Yunfei
;
Wang, Yingcong
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
Multiple Myeloma
DCZ3301
antitumor activities
synergistic cytotoxicity
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