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科研机构
上海药物研究所 [125]
内容类型
期刊论文 [123]
会议论文 [2]
发表日期
2021 [14]
2020 [17]
2019 [12]
2018 [7]
2017 [11]
2016 [8]
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Pharmacolo... [3]
Chemistry [2]
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A camptothecin-based, albumin-binding prodrug enhances efficacy and safety in vivo
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 226, 页码: 11
作者:
Cheng, Zhiyang
;
Huang, Ying
;
Shen, Qianqian
;
Zhao, Yangrong
;
Wang, Lei
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2021/11/04
Cancer
beta-glucuronidase
Bioconjugation
Albumin
Camptothecin
SN38-based albumin-binding prodrug for efficient targeted cancer chemotherapy
期刊论文
JOURNAL OF CONTROLLED RELEASE, 2021, 卷号: 339, 页码: 297-306
作者:
Huang, Ying
;
Wang, Lei
;
Cheng, Zhiyang
;
Yang, Biyu
;
Yu, Jiahui
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/12/01
Antitumour
Chemotherapy
SN38
Drug delivery systems
Albumin
Genetically-engineered "all-in-one" vaccine platform for cancer immunotherapy
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 11, 页码: 3622-3635
作者:
Wu, Aihua
;
Chen, Yingzhi
;
Wang, Hairui
;
Chang, Ya
;
Zhang, Meng
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/01/18
Trichosanthin
Legumain
TRP2
Transcutaneous immunization
Adjuvant
Cancer vaccine
Protein engineering
A validated HPLC-MS/MS method for determination of simmitecan and its metabolite chimmitecan in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor
期刊论文
JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 8
作者:
Zhou, Jun
;
Zhan, Yan
;
Zhong, Dafang
;
Chen, Xiaoyan
;
Zhang, Yifan
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2021/11/04
chimmitecan
mass spectrometry
pharmacokinetics
simmitecan
solid tumors
Lipophilic Conjugates of Drugs: A Tool to Improve Drug Pharmacokinetic and Therapeutic Profiles
期刊论文
PHARMACEUTICAL RESEARCH, 2021, 页码: 22
作者:
Han, Sifei
;
Mei, Lianghe
;
Quach, Tim
;
Porter, Chris
;
Trevaskis, Natalie
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/11/04
conjugate
lipid
lymphatic
pharmacokinetics
prodrug
Engineering Chameleon Prodrug Nanovesicles to Increase Antigen Presentation and Inhibit PD-L1 Expression for Circumventing Immune Resistance of Cancer
期刊论文
ADVANCED MATERIALS, 2021, 页码: 12
作者:
Zhou, Fengqi
;
Gao, Jing
;
Tang, Yang
;
Zou, Zhifeng
;
Jiao, Shi
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/11/04
antigen presentation
autophagy inhibition
immune resistance
immunotherapy
prodrug nanovesicles
Enzyme-Activated Prodrug-Based Smart Liposomes Specifically Enhance Tumor Hemoperfusion with Efficient Drug Delivery to Pancreatic Cancer Cells and Stellate Cells
期刊论文
ADVANCED FUNCTIONAL MATERIALS, 2021, 页码: 14
作者:
Duan, Nianxiu
;
Li, Junjun
;
Song, Sha
;
Wang, Feng
;
Yang, Yiwei
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/11/04
drug delivery
pancreatic cancer
prodrugs
smart liposomes
tumor-specific vascular promotion
Engineering Oxaliplatin Prodrug Nanoparticles for Second Near-Infrared Fluorescence Imaging-Guided Immunotherapy of Colorectal Cancer
期刊论文
SMALL, 2021, 卷号: 17, 期号: 13, 页码: 11
作者:
Zhu, Qiurong
;
Sun, Fang
;
Li, Tianliang
;
Zhou, Mengxue
;
Ye, Jiayi
收藏
  |  
浏览/下载:108/0
  |  
提交时间:2021/05/24
colorectal cancer
combinatory immunotherapy
immunogenic cell death
prodrug nanoparticles
second near‐
infrared fluorescence imaging
Oxygen-Delivering Polyfluorocarbon Nanovehicles Improve Tumor Oxygenation and Potentiate Photodynamic-Mediated Antitumor Immunity
期刊论文
ACS NANO, 2021, 卷号: 15, 期号: 3, 页码: 5405-5419
作者:
Wang, Zhiwan
;
Gong, Xiang
;
Li, Jie
;
Wang, Hong
;
Xu, Xiaoxuan
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2021/05/24
polyfluorocarbon
nanovehicle
oxygen
tumor hypoxia
antitumor immunity
Challenges and stepwise fit-for-purpose optimization for bioanalyses of remdesivir metabolites nucleotide monophosphate and triphosphate in mouse tissues using LC-MS/MS
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 194, 页码: 10
作者:
Hu, Wenjuan
;
Chang, Lu
;
Ke, Changqiang
;
Xie, Yuanchao
;
Shen, Jingshan
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/05/24
Remdesivir
Nucleotide monophosphate
Nucleotide triphosphate
Stability
Recovery
LC-MS/MS
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