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Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 21, 页码: 7079-7088
作者:  Liu, Peihong;  Du, Yongli;  Song, Lianhua;  Shen, Jingkang;  Li, Qunyi
收藏  |  浏览/下载:13/0  |  提交时间:2019/01/08
Discovery of novel, potent, selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel design 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 15, 页码: 4891-4898
作者:  Du, Yongli;  Ling, Hao;  Zhang, Meng;  Shen, Jingkang;  Li, Qunyi
收藏  |  浏览/下载:14/0  |  提交时间:2019/01/08
4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 14, 页码: 3670-3683
作者:  Zhi, Ying;  Gao, Li-Xin;  Jin, Yi;  Tang, Chun-Lan;  Li, Jing-Ya
收藏  |  浏览/下载:20/0  |  提交时间:2019/01/08
Ligand-Based Structural Optimization of Grb2-SH2 Inhibitors: High Affinity, Low Charge and Reduced Peptidic Nature 期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2011, 卷号: 31, 期号: 12, 页码: 2019-2033
作者:  Peng Dian;  Zhi Ying;  Xue Ting;  Gao Huiyuan;  Long Yaqiu
收藏  |  浏览/下载:13/0  |  提交时间:2019/01/08
基于配体结构的grb2sh2抑制剂的结构优化更高的活性更少的电荷更低的肽性 期刊论文
有机化学, 2011, 卷号: 31, 期号: 12, 页码: 2019
作者:  彭电;  智英;  薛婷;  高慧媛;  龙亚秋
收藏  |  浏览/下载:1/0  |  提交时间:2020/07/01
Synthesis and Utilization of Chiral alpha-Methylated alpha-Amino Acids with a Carboxyalkyl Side Chain in the Design of Novel Grb2-SH2 Peptide Inhibitors Free of Phosphotyrosine 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2008, 卷号: 51, 期号: 20, 页码: 6371-6380
作者:  Long, Ya-Qiu;  Xue, Ting;  Song, Yan-Li;  Liu, Zu-Long;  Huang, Shao-Xu
收藏  |  浏览/下载:15/0  |  提交时间:2019/01/08
Discovery of a novel nonphosphorylated pentapeptide motif displaying high affinity for Grb2-SH2 domain by the utilization of 3 '-substituted tyrosine derivatives 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2006, 卷号: 49, 期号: 5, 页码: 1585-1596
作者:  Song, YL;  Peach, ML;  Roller, PP;  Qiu, S;  Wang, SM
收藏  |  浏览/下载:10/0  |  提交时间:2019/01/08
Altered regulation of protein tyrosine phosphorylation in anikis-resistant tumor cells 期刊论文
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2005, 卷号: 32, 期号: 11, 页码: 1047-1054
作者:  Zhang, LN;  Zha, XL;  Yu, Q
收藏  |  浏览/下载:15/0  |  提交时间:2019/01/08
Development of L-3-aminotyrosine suitably protected for the synthesis of a novel nonphosphorylated hexapeptide with low-nanomolar Grb2-SH2 domain-binding affinity 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 卷号: 14, 期号: 12, 页码: 3205-3208
作者:  Song, YL;  Roller, PP;  Long, YQ
收藏  |  浏览/下载:9/0  |  提交时间:2019/01/08
Potentiating effect of distant sites in non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain 期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 卷号: 310, 期号: 2, 页码: 334-340
作者:  Long, YQ;  Guo, RB;  Luo, JH;  Yang, DJ;  Roller, PP
收藏  |  浏览/下载:16/0  |  提交时间:2019/01/08


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