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科研机构
上海药物研究所 [11]
内容类型
期刊论文 [11]
发表日期
2021 [4]
2020 [2]
2019 [3]
2013 [1]
2006 [1]
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Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Dong, Ying
;
Tang, Bi-xi
;
Wang, Qi
;
Zhou, Li-wei
;
Li, Cong
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2022/01/04
idiopathic pulmonary fibrosis
DDRs
kinase inhibitor
indazole derivatives
XBLJ-13
nintedanib
bleomycin-induced pulmonary fibrosismouse model
Nyctinastic herbs decoction improves para-chlorophenylalanine-induced insomnia by regulating the expression level of neurotransmitters
期刊论文
ANNALS OF TRANSLATIONAL MEDICINE, 2021, 卷号: 9, 期号: 20, 页码: 16
作者:
Yang, Yiwen
;
Wu, You
;
Xu, Peiqin
;
Guo, Fan
;
Guo, Fei
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/12/16
Nyctinastic herbs decoction (NHD)
para-chlorophenylalanine (PCPA)
insomnia
electroencephalograph (EEG)
behavior
neurotransmitters
Effects of Food on the Pharmacokinetic Properties and Mass Balance of Henagliflozin in Healthy Male Volunteers
期刊论文
CLINICAL THERAPEUTICS, 2021, 卷号: 43, 期号: 9, 页码: E264-E273
作者:
Chen, Zhen-dong
;
Chen, Qian
;
Zhu, Yun-ting
;
Zhang, Yi-fan
;
Zhan, Yan
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2022/01/04
henagliflozin
food effects
mass balance
pharmacokinetics
SGLT-2 inhibitor
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
Original Pharmacodynamic and pharmacokinetic effects of S086, a novel angiotensin receptor neprilysin inhibitor
期刊论文
BIOMEDICINE & PHARMACOTHERAPY, 2020, 卷号: 129, 页码: 10
作者:
Sun, Jingchao
;
Xu, Wenjie
;
Hua, Huaijie
;
Xiao, Ying
;
Chen, Xiaoyan
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/24
Angiotensin receptor-NEP inhibitor
Heart failure
Neprilysin inhibitor
Angiotensin receptor blocker
The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor
期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 45, 期号: 1, 页码: 15-26
作者:
Zhang, Leduo
;
Mao, Yu
;
Gao, Zhiwei
;
Chen, Xiaoyan
;
Li, Xin
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2020/07/01
Simultaneous determination of cinobufagin and its five metabolites in rat plasma by LC-MS/MS for characterization of metabolic profiles and pharmacokinetic study
期刊论文
ANALYTICAL METHODS, 2019, 卷号: 11, 期号: 42, 页码: 5464-5471
作者:
Wei, Wenlong
;
Li, Haojv
;
Li, Zhenwei
;
Qu, Hua
;
Da, Juan
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  |  
浏览/下载:55/0
  |  
提交时间:2020/07/01
Antitumor, Antiviral, and Anti-Inflammatory Efficacy of Essential Oils from Atractylodes macrocephala Koidz. Produced with Different Processing Methods
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 16, 页码: 14
作者:
Gu, Sihao
;
Li, Ling
;
Huang, Hai
;
Wang, Bing
;
Zhang, Tong
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
Atractylodes macrocephala Koidz
essential oils
atractylone
processing methods
GC
MS
pharmacodynamic effect
Simultaneous Determination of Bufalin and Its Nine Metabolites in Rat Plasma for Characterization of Metabolic Profiles and Pharmacokinetic Study by LC-MS/MS
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 9, 页码: 15
作者:
Wei, Wenlong
;
Yu, Yang
;
Wang, Xia
;
Yang, Linhui
;
Zhang, Hang
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
bufalin
metabolite
quantification
pharmacokinetics
Application of methyl in drug design
期刊论文
Acta Pharmaceutica Sinica, 2013, 卷号: 48, 期号: 8, 页码: 1195-1208
作者:
Lian Jie
;
Wang Jiang
;
Sun Haifeng
;
Lin Daizong
;
Liu Hong
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
methyl
drug design
lead optimization
stereoelectronic effect
liposolubility
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