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科研机构
上海药物研究所 [26]
内容类型
期刊论文 [26]
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2021 [1]
2019 [1]
2018 [4]
2017 [2]
2015 [2]
2014 [1]
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A novel GPR120-selective agonist promotes insulin secretion and improves chronic inflammation
期刊论文
LIFE SCIENCES, 2021, 卷号: 269, 页码: 8
作者:
Yang, Liu
;
Lei, Xian-Tao
;
Huang, Qi
;
Wang, Ting
;
Sun, Hong-Bin
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/05/24
GPR120 agonist
Insulin secretion
Anti-inflammation
Insulin resistance
Type 2 diabetes mellitus
Enhanced Anti-diabetic Effect of Berberine Combined With Timosaponin B2 in Goto-Kakizaki Rats, Associated With Increased Variety and Exposure of Effective Substances Through Intestinal Absorption
期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 15
作者:
Tian, Xiaoting
;
Liu, Fang
;
Li, Zhixiong
;
Lin, Yunfei
;
Liu, Huan
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
berberine
timosaponin B2
diabetes
combination treatments
drug-drug interaction
metabolites
hepatic metabolism
intestinal absorption
Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 22, 页码: 5780-5791
作者:
Guo, Bin
;
Guo, Shimeng
;
Huang, Jing
;
Li, Jingya
;
Li, Jia
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
GPR40 agonist
2,3-Dihydrobenzo[b][1,4]dioxine
Insulin secretion
Type 2 diabetes mellitus
Anti-diabetic Effect of Punica granatum Flower Polyphenols Extract in Type 2 Diabetic Rats: Activation of Akt/GSK-3 beta and Inhibition of IRE1 alpha-XBP1 Pathways
期刊论文
FRONTIERS IN ENDOCRINOLOGY, 2018, 卷号: 9
作者:
Tang, Dan
;
Liu, Liu
;
Ajiakber, Dildar
;
Ye, Jianping
;
Xu, Jianjun
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2019/01/08
type 2 diabetes mellitus
Punica granatum L. flower
anti-diabetic herb
oral glucose tolerance test
endoplasmic reticulum stress
insulin resistance
Discovery of novel selective GPR120 agonists with potent anti-diabetic activity by hybrid design
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 15, 页码: 2599-2604
作者:
Sheng, Ren
;
Yang, Liu
;
Zhang, Yanchun
;
Xing, Enming
;
Shi, Rui
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
GPR120
Agonist biphenyl derivatives
OGTT
Type 2 diabetes
Effect of Medium-chain Fatty Acid-sensing Receptor GPR84 on Glucose and Lipid Metabolism in Mice
期刊论文
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2018, 卷号: 45, 期号: 8, 页码: 853-864
作者:
Fang You-Chen
;
Zheng Yang
;
Zheng Qing
;
Li Jing
;
Xie Xin
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
GPR84
medium-chain fatty acid-sensing receptor
obesity
lipid metabolism
hypercholesterolemia
Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 页码: 128-152
作者:
Wang, Zhengyu
;
Shi, Xiaofan
;
Zhang, Huan
;
Yu, Liang
;
Cheng, Yanhua
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/01/08
Type 2 diabetes mellitus
Hypoglycemia
Dyslipidemia
Glucokinase activators
N-Thiazol-2-yl-benzamides
Lowered fasting chenodeoxycholic acid correlated with the decrease of fibroblast growth factor 19 in Chinese subjects with impaired fasting glucose
期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7
作者:
Zhang, Jing
;
Li, Huating
;
Zhou, Hu
;
Fang, Li
;
Xu, Jingjing
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
Antidiabetic effects of flavonoids from Sophora flavescens EtOAc extract in type 2 diabetic KK-ay mice
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2015, 卷号: 171, 页码: 161-170
作者:
Yang, Xinzhou
;
Yang, Jing
;
Xu, Chan
;
Huang, Mi
;
Zhou, Qi
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Antidiabetic
Sophora flavescens
KKAy mice
GLUT4
AMPK
Off-line HPLC-NMR
Design, Synthesis, and Pharmacological Evaluation of Fused beta-Homophenylalanine Derivatives as Potent DPP-4 Inhibitors
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2015, 卷号: 6, 期号: 5, 页码: 602-606
作者:
Jiang, Tao
;
Zhou, Yuren
;
Chen, Zhuxi
;
Sun, Peng
;
Zhu, Jianming
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
Diabetes
DPP-4 inhibitor
beta-homophenylalanine derivatives
sitagliptin
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