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科研机构
上海药物研究所 [22]
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期刊论文 [22]
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2021 [3]
2020 [1]
2019 [2]
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Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel alpha-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 115, 页码: 17
作者:
Xie, Hong-Xu
;
Zhang, Juan
;
Li, Yue
;
Zhang, Jin-He
;
Liu, Shan-Kui
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2021/11/04
Tetrahydrobenzo[b]thiophen-2-yl)urea
alpha-Glucosidase inhibitors
Non-competitive inhibitor
Molecular docking
Anti-hyperglycaemic activity
Type 2 diabetes
Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK
期刊论文
CLINICAL SCIENCE, 2021, 卷号: 135, 期号: 19, 页码: 2243-2263
作者:
Elksnis, Andris
;
Schiffer, Tomas A.
;
Palm, Fredrik
;
Wang, Yun
;
Cen, Jing
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/12/01
Direct Cardiac Actions of the Sodium Glucose Co-Transporter 2 Inhibitor Empagliflozin Improve Myocardial Oxidative Phosphorylation and Attenuate Pressure-Overload Heart Failure
期刊论文
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2021, 卷号: 10, 期号: 6, 页码: 33
作者:
Li, Xuan
;
Lu, Qingguo
;
Qiu, Yunguang
;
do Carmo, Jussara M.
;
Wang, Zhen
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
cardiac hypertrophy
cardiac metabolism
cardiomyocytes
sodium glucose cotransporter 2
transverse aortic constriction
A novel salviadione derivative, compound 15a, attenuates diabetes-induced renal injury by inhibiting NF-kappa B-mediated inflammatory responses
期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 卷号: 409, 页码: 11
作者:
Li, Li
;
Ding, Chunyong
;
Zou, Chunpeng
;
Xiong, Zhi
;
Zhu, Weiwei
收藏
  |  
浏览/下载:98/0
  |  
提交时间:2021/05/24
Salviadione derivative 15a
Diabetic nephropathy
Inflammation
Macrophage infiltration
Fibrosis
Nuclear factor-kappa B
Cytokines
Enhanced Anti-diabetic Effect of Berberine Combined With Timosaponin B2 in Goto-Kakizaki Rats, Associated With Increased Variety and Exposure of Effective Substances Through Intestinal Absorption
期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 15
作者:
Tian, Xiaoting
;
Liu, Fang
;
Li, Zhixiong
;
Lin, Yunfei
;
Liu, Huan
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
berberine
timosaponin B2
diabetes
combination treatments
drug-drug interaction
metabolites
hepatic metabolism
intestinal absorption
magnesiumlithospermatebimprovesthegutmicrobiomeandbileacidmetabolicprofilesinamousemodelofdiabeticnephropathy
期刊论文
中国药理学报英文版, 2019, 卷号: 040, 期号: 004, 页码: 507
作者:
Jing Zhao
;
Qingli Zhang
;
Jianhua Shen
;
Kai Wang
;
Jia Liu
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/07/01
magnesium
lithospermate
B
diabetic
nephropathy
intestinal
microbiota
bile
acid
Magnesium lithospermate B improves the gut microbiome and bile acid metabolic profiles in a mouse model of diabetic nephropathy
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Zhao, Jing
;
Zhang, Qing-Li
;
Shen, Jian-Hua
;
Wang, Kai
;
Liu, Jia
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 页码: 128-152
作者:
Wang, Zhengyu
;
Shi, Xiaofan
;
Zhang, Huan
;
Yu, Liang
;
Cheng, Yanhua
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/01/08
Type 2 diabetes mellitus
Hypoglycemia
Dyslipidemia
Glucokinase activators
N-Thiazol-2-yl-benzamides
The non-peptide GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating beta-endorphin release from spinal microglia
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2015, 卷号: 172, 期号: 1, 页码: 64-79
作者:
Fan, Hui
;
Gong, Nian
;
Li, Teng-Fei
;
Ma, Ai-Niu
;
Wu, Xiao-Yan
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
The Evolution of Insulin Glargine and its Continuing Contribution to Diabetes Care
期刊论文
DRUGS, 2014, 卷号: 74, 期号: 8, 页码: 911-927
作者:
Hilgenfeld, Rolf
;
Seipke, Gerhard
;
Berchtold, Harald
;
Owens, David R.
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
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