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科研机构
上海药物研究所 [66]
内容类型
期刊论文 [66]
发表日期
2021 [3]
2020 [6]
2019 [3]
2018 [5]
2017 [9]
2016 [8]
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Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Zou, Hui-xi
;
Zhang, Yu-feng
;
Zhong, Da-fang
;
Jiang, Yong
;
Liu, Fei
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/01/04
furmonertinib
autoinduction
food effect
alkaline phosphatase
body weight
pharmacokinetics
modeling and simulation
NSCLC
Molecular Dynamics Simulations Reveal the Modulated Mechanism of STING Conformation
期刊论文
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, 2021, 页码: 15
作者:
Chen, Li
;
Zhao, Shuang
;
Zhu, Yanyan
;
Liu, Yongsheng
;
Li, Huiyu
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/08/17
STING
Small molecule
Binding site
Modulated mechanism
Molecular dynamics simulation
pi-pi stacking interaction
Activating Adenosine Monophosphate-Activated Protein Kinase Mediates Fibroblast Growth Factor 1 Protection From Nonalcoholic Fatty Liver Disease in Mice
期刊论文
HEPATOLOGY, 2021, 卷号: 73, 期号: 6, 页码: 2206-2222
作者:
Lin, Qian
;
Huang, Zhifeng
;
Cai, Genxiang
;
Fan, Xia
;
Yan, Xiaoqing
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/08/17
Lipid-Lowering Activities of Cucurbitacins Isolated from Trichosanthes cucumeroides and Their Synthetic Derivatives
期刊论文
JOURNAL OF NATURAL PRODUCTS, 2020, 卷号: 83, 期号: 12, 页码: 3536-3544
作者:
Zhang, Xianjing
;
Li, Huihui
;
Wang, Wenqiong
;
Chen, Tong
;
Xuan, Lijiang
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2021/05/24
Resistance to Some But Not Other Dimeric Lindenane Sesquiterpenoid Esters Is Mediated by Mutations in a Plasmodium falciparum Esterase
期刊论文
ACS INFECTIOUS DISEASES, 2020, 卷号: 6, 期号: 11, 页码: 2994-3003
作者:
Butler, Joshua H.
;
Baptista, Rodrigo P.
;
Valenciano, Ana L.
;
Zhou, Bin
;
Kissinger, Jessica C.
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2021/05/24
Plasmodium
PfPARE
structure-resistance relationship study
Malaria Box
Pathogen Box
lindenane sesquiterpenoid dimers
Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 19, 页码: 10972-10983
作者:
Ma, Yuqin
;
Luo, Qichao
;
Fu, Jie
;
Che, Yanxin
;
Guo, Fei
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2021/05/24
Repeated Nitrous Oxide Exposure Exerts Antidepressant-Like Effects Through Neuronal Nitric Oxide Synthase Activation in the Medial Prefrontal Cortex
期刊论文
FRONTIERS IN PSYCHIATRY, 2020, 卷号: 11, 页码: 11
作者:
Liu, Wei
;
Li, Qian
;
Ye, Binglu
;
Cao, Hang
;
Shen, Fuyi
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/12/21
nitrous oxide (N2O)
depression
mPFC
burst firing
neuronal nitric oxide synthase (nNOS)
BDNF
Repeated Nitrous Oxide Exposure Exerts Antidepressant-Like Effects Through Neuronal Nitric Oxide Synthase Activation in the Medial Prefrontal Cortex
期刊论文
FRONTIERS IN PSYCHIATRY, 2020, 卷号: 11, 页码: 11
作者:
Liu, Wei
;
Li, Qian
;
Ye, Binglu
;
Cao, Hang
;
Shen, Fuyi
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/21
nitrous oxide (N2O)
depression
mPFC
burst firing
neuronal nitric oxide synthase (nNOS)
BDNF
Inhibition of human thrombin by the constituents of licorice: inhibition kinetics and mechanistic insights through in vitro and in silico studies
期刊论文
RSC ADVANCES, 2020, 卷号: 10, 期号: 7, 页码: 3626-3635
作者:
Shi, Cheng-Cheng
;
Chen, Tian-Ran
;
Zhang, Qi-Hua
;
Wei, Ling-Hua
;
Huang, Chao
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
SCFFBXW7/GSK3 beta-Mediated GFI1 Degradation Suppresses Proliferation of Gastric Cancer Cells
期刊论文
CANCER RESEARCH, 2019, 卷号: 79, 期号: 17, 页码: 4387-4398
作者:
Kuai, Xiaoling
;
Li, Long
;
Chen, Ran
;
Wang, Kangjunjie
;
Chen, Min
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
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