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科研机构
上海药物研究所 [236]
内容类型
期刊论文 [232]
会议论文 [4]
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2021 [9]
2020 [8]
2019 [8]
2018 [14]
2017 [11]
2016 [11]
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Chemistry [12]
Biochemist... [9]
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A simultaneous identification and quantification strategy for determination of sulfhydryl-containing metabolites in normal- and high-fat diet hamsters using stable isotope labeling combined with LC-MS
期刊论文
ANALYTICA CHIMICA ACTA, 2021, 卷号: 1184, 页码: 13
作者:
Chang, Lu
;
Lin, Feifei
;
Cheng, Kai
;
Li, Jiaomeng
;
Sun, Xiaochu
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2022/01/18
Sulfhydryl-containing metabolites
Stable isotope labeling
Identification
Quantification
Hyperlipidemia
Oxidative stress
A five-dimensional data collection strategy for multicomponent discovery and characterization in Traditional Chinese Medicine: Gastrodia Rhizoma as a case study
期刊论文
JOURNAL OF CHROMATOGRAPHY A, 2021, 卷号: 1653, 页码: 12
作者:
Zhu, Haodong
;
Wu, Xingdong
;
Huo, Jiangyan
;
Hou, Jinjun
;
Long, Huali
收藏
  |  
浏览/下载:99/0
  |  
提交时间:2021/11/04
Gastrodia Rhizoma
Multidimensional data acquisition
Offline 2D-LC-IMS-DIA MS
MS
Neutral loss (NLs)
Collision cross section (CCS)
Liquid chromatography-mass spectrometry method for the quantification of an anti-sclerostin monoclonal antibody in cynomolgus monkey serum
期刊论文
JOURNAL OF PHARMACEUTICAL ANALYSIS, 2021, 卷号: 11, 期号: 4, 页码: 472-479
作者:
Gao, Yuxiong
;
Chen, Zhendong
;
Yang, Changyong
;
Zhong, Dafang
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/11/04
Anti-sclerostin monoclonal antibody (SHR-1222)
LC-MS/MS
Anti-drug antibody
Toxicokinetic
Fast determination of 16 circulating neurotransmitters and their metabolites in plasma samples of spontaneously hypertensive rats intervened with five different Uncaria
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2021, 卷号: 1179, 页码: 9
作者:
Gao, Lei
;
Zhang, Zijia
;
Feng, Zijin
;
Wei, Wenlong
;
Wu, Wenyong
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/11/04
Neurotransmitters
LC-MS
Hypertension
Uncaria
Spontaneously hypertensive rats
Simultaneous determination of forsythin and its major metabolites in human plasma via liquid chromatography-tandem mass spectrometry
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 198, 页码: 7
作者:
Pan, Lu-lu
;
Chen, Tao
;
Hui, Min
;
Wang, Shuo
;
Fu, Li
收藏
  |  
浏览/下载:131/0
  |  
提交时间:2021/05/24
LC-MS/MS
Forsythin
Aglycone glucuronide
Aglycone sulfate
Pharmacokinetics
An enhanced strategy integrating offline superimposed two-dimensional separation with mass defect filter and diagnostic ion filter: Comprehensive characterization of steroid alkaloids in Fritillariae Pallidiflorae Bulbus as a case study
期刊论文
JOURNAL OF CHROMATOGRAPHY A, 2021, 卷号: 1643, 页码: 10
作者:
An, Ya-ling
;
Wei, Wen-long
;
Li, Hao-jv
;
Li, Zhen-wei
;
Yao, Chang-liang
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2021/05/24
Mass defect filter
Diagnostic ion filter
Comprehensive characterization
Steroid alkaloids
Fritillariae Pallidiflorae Bulbus
Offline superimposed two-dimensional separation
Recent advances in chemical analysis of licorice (Gan-Cao)
期刊论文
FITOTERAPIA, 2021, 卷号: 149, 页码: 12
作者:
Cheng, Mengzhen
;
Zhang, Jianqing
;
Yang, Lin
;
Shen, Shijie
;
Li, Ping
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/05/24
Glycyrrhiza uralensis
Glycyrrhiza glabra
Glycyrrhiza inflata
Gan-Cao
Qualitative and quantitative analysis
Biological sample
Challenges and stepwise fit-for-purpose optimization for bioanalyses of remdesivir metabolites nucleotide monophosphate and triphosphate in mouse tissues using LC-MS/MS
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 194, 页码: 10
作者:
Hu, Wenjuan
;
Chang, Lu
;
Ke, Changqiang
;
Xie, Yuanchao
;
Shen, Jingshan
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/05/24
Remdesivir
Nucleotide monophosphate
Nucleotide triphosphate
Stability
Recovery
LC-MS/MS
Characterization and quantitative determination of henagliflozin metabolites in humans
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 192, 页码: 8
作者:
Chen, Zhendong
;
Li, Liang
;
Zhan, Yan
;
Zhang, Yifan
;
Liu, Haiyan
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/05/24
Henagliflozin
Metabolism
LC-MS/MS
Offline two-dimensional liquid chromatography coupled with ion mobility-quadrupole time-of-flight mass spectrometry enabling four-dimensional separation and characterization of the multicomponents from white ginseng and red ginseng
期刊论文
JOURNAL OF PHARMACEUTICAL ANALYSIS, 2020, 卷号: 10, 期号: 6, 页码: 597-609
作者:
Zuo, Tiantian
;
Zhang, Chunxia
;
Li, Weiwei
;
Wang, Hongda
;
Hu, Ying
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/05/24
Dimension-enhanced strategy
Multicomponent characterization
Ginsenoside
Offline two-dimensional liquid chromatography
Ion mobility-quadrupole time-of-flight mass spectrometry
In-house database
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