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科研机构
上海药物研究所 [10]
内容类型
期刊论文 [10]
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2019 [2]
2018 [2]
2016 [2]
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2010 [1]
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Targeting lipid metabolism to overcome EMT-associated drug resistance via integrin beta 3/FAK pathway and tumor-associated macrophage repolarization using legumain-activatable delivery
期刊论文
THERANOSTICS, 2019, 卷号: 9, 期号: 1, 页码: 265-278
作者:
Jin, Hongyue
;
He, Yang
;
Zhao, Pengfei
;
Hu, Ying
;
Tao, Jin
收藏
  |  
浏览/下载:97/0
  |  
提交时间:2019/01/08
Epithelial-mesenchymal transition
cholesterol metabolism
tumor-associated macrophages
simvastatin
drug resistance
legumain
Inhibition of HSP90 beta Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System
期刊论文
THERANOSTICS, 2019, 卷号: 9, 期号: 20, 页码: 5769-5783
作者:
Zheng, Zu-Guo
;
Zhang, Xin
;
Liu, Xiao-Xiao
;
Jin, Xiu-Xiu
;
Dai, Lunzhi
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
HSP90 beta
lipid metabolism
corylin
SREBPs
proteasomal degradation
Optimal extraction of Phaeoporus obliquus saponins and its scavenging effect on fat accumulation in HepG2 cells
期刊论文
Journal of Jilin Univeristy. Medicine edition, 2018, 卷号: 44, 期号: 3, 页码: 526-531
作者:
Zhang Lei
;
Zhang Kun
;
Wang Deli
;
Ren Xiaohong
;
Cui Na
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
Phaeoporus obliquus
saponins
HepG2 cells
triglyceride
fat accumulation
Research progress on pharmacological effects of Gynostemma pentaphyllum active ingredients
期刊论文
Chinese Journal of New Drugs and Clinical Remedies, 2018, 卷号: 37, 期号: 1, 页码: 11-17
作者:
BAO Feng-xia
;
TAO Ling-xue
;
ZHANG Hai-yan
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Gynostemma pentaphyllum
saponins
polysaccharides
flavones
pharmacological actions
A lipidomics study reveals hepatic lipid signatures associating with deficiency of the LDL receptor in a rat model
期刊论文
Biology open, 2016, 卷号: 5, 期号: 7, 页码: 979-86
作者:
Wang, Hong Yu
;
Quan, Chao
;
Hu, Chunxiu
;
Xie, Bingxian
;
Du, Yinan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice
期刊论文
DIABETOLOGIA, 2016, 卷号: 59, 期号: 6, 页码: 1276-1286
作者:
Feng, Li
;
Luo, Huan
;
Xu, Zhijian
;
Yang, Zhuo
;
Du, Guoxin
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2019/01/08
Alternative binding site
Bavachinin
Canonical ligand-binding pocket
Carbohydrate metabolism
Lipid metabolism
Pan-PPAR agonist
Synergistic effects
2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b] thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 4, 页码: 483-496
作者:
Zhang, Jin
;
Zhang, Li-na
;
Chen, Dong-mei
;
Fu, Yan-yun
;
Zhang, Feng
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/01/08
2-(3-benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b] thiophene-3-carboxylic acid
lipogenesis
SREBP-1c
AMPK
mTOR
hepatic lipid accumulation
obesity
metabolic disorders
Latanoprost effectively ameliorates glucose and lipid disorders in db/db and ob/ob mice
期刊论文
DIABETOLOGIA, 2013, 卷号: 56, 期号: 12, 页码: 2702-2712
作者:
Wang, Gaihong
;
Xu, Xing
;
Yao, Xingang
;
Zhu, Zhiyuan
;
Yu, Liang
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
AMPK
Glucose and lipid metabolism
Latanoprost
RXR alpha/PPAR gamma heterodimer
Type 2 diabetes
The characteristics and mechanism of simvastatin loaded lipid nanoparticles to increase oral bioavailability in rats
期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 卷号: 394, 期号: 1-2, 页码: 147-153
作者:
Zhang, Zhiwen
;
Bu, Huihui
;
Gao, Zhiwei
;
Huang, Yan
;
Gao, Fang
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/01/08
Simvastatin
Simvastatin acid
Lipid nanoparticles
Intestinal absorption
Bioavailability
Current status of studies on Acyl-CoA: Cholesterol Acyltransferase (ACAT) inhibitors
期刊论文
Chinese Journal New Drugs, 2005, 卷号: 14, 期号: 4, 页码: 396-400
作者:
Din Derong
;
Shen Jingkang
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/01/08
ACAT inhibitor
atherosclerosis
cholesterol-lowering
lipid-lowering
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