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科研机构
上海药物研究所 [39]
内容类型
期刊论文 [36]
会议论文 [3]
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2021 [2]
2019 [2]
2018 [1]
2017 [3]
2016 [5]
2013 [1]
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Oncology [1]
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Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:
Shackleford, David M.
;
Chiu, Francis C. K.
;
Katneni, Kasiram
;
Blundell, Scott
;
McLaren, Jenna
收藏
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浏览/下载:59/0
  |  
提交时间:2021/11/04
OZ439 (artefenomel)
malaria
metabolite identification
cytochrome P450 metabolism
cytochrome P450 inhibition
time-dependent inhibition
Structural optimization and biological evaluation for novel artemisinin derivatives against liver and ovarian cancers
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 13
作者:
Zhou, Yu
;
Li, Xiaoguang
;
Chen, Kerong
;
Ba, Qian
;
Zhang, Xu
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/05/24
Structural optimization
Lead compound
Artemisinin derivatives
Cancer
Novel dihydroartemisinin dimer containing nitrogen atoms inhibits growth of endometrial cancer cells and may correlate with increasing intracellular peroxynitrite
期刊论文
SCIENTIFIC REPORTS, 2019, 卷号: 9, 页码: 14
作者:
Zhu, Yan
;
Klausen, Christian
;
Zhou, Jieyun
;
Guo, Xiangjie
;
Zhang, Yu
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  |  
浏览/下载:81/0
  |  
提交时间:2020/07/01
Quantitative Analysis of Artemisinin Derivatives: Applications and Techniques
期刊论文
SEPARATION AND PURIFICATION REVIEWS, 2019, 卷号: 48, 期号: 3, 页码: 242-266
作者:
Zhang, Lili
;
Jiang, Yanyan
;
Li, Ning
;
Pu, Yiqiong
;
Zhang, Tong
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  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
Artemisinin derivatives
quantitative analysis
spectroscopy
chromatography
mass spectrometry
Development of high potent and selective Bcl-2 inhibitors bearing the structural elements of natural product artemisinin
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 159, 页码: 149-165
作者:
Liu, Xiaohua
;
Zhang, Yu
;
Huang, Wenjing
;
Luo, Jia
;
Li, Yang
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/01/08
Apoptosis
Artemisinin
Bcl-2
Venetoclax
Selectivity
Dihydroartemisinin selectively inhibits PDGFR alpha-positive ovarian cancer growth and metastasis through inducing degradation of PDGFR alpha protein
期刊论文
CELL DISCOVERY, 2017, 卷号: 3
作者:
Li, Xiaoguang
;
Ba, Qian
;
Liu, Yanling
;
Yue, Qingxi
;
Chen, Peizhan
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/01/08
Dihydroartemisinin
Epithelial-mesenchymal transition
metastasis
ovarian cancer
PDGFR alpha
Incorporation of Dihydroartemisinin into Memantine Through a Propriate Spacer to Make Hybrid with Enhanced Effects to Protect PC12 Cells from Corticosterone-caused Impairments
期刊论文
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2017, 卷号: 33, 期号: 4, 页码: 611-622
作者:
Zhang Lei
;
Zhou Fan
;
Zhang Laitao
;
Peng Lizhi
;
Guo Cuiping
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  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Artemisinin
Memantine
Neuroprotection
N-Methyl-D-aspartate(NMDA) receptor
Depression
Codelivery of dihydroartemisinin and doxorubicin in mannosylated liposomes for drug-resistant colon cancer therapy
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 6, 页码: 885-896
作者:
Kang, Xue-jia
;
Wang, Hui-yuan
;
Peng, Hui-ge
;
Chen, Bin-fan
;
Zhang, Wen-yuan
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
human colon cancer
multidrug resistance
doxorubicin
dihydroartemisinin
combination therapy
tumor-targeted delivery
mannosylated liposome
mannose receptor
Preclinical Efficacy and Safety Assessment of Artemisinin-Chemotherapeutic Agent Conjugates for Ovarian Cancer
期刊论文
EBIOMEDICINE, 2016, 卷号: 14, 页码: 44-54
作者:
Li, Xiaoguang
;
Zhou, Yu
;
Liu, Yanling
;
Zhang, Xu
;
Chen, Tao
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
Dihydroartemisinin
Drug conjugates
Cell cycle
Apoptosis
Metastasis
Ovarian cancer
Novel dihydroisoxazoline-alkyl carbon chain hybrid artemisinin analogues (artemalogs): synthesis and antitumor activities
期刊论文
RSC ADVANCES, 2016, 卷号: 6, 期号: 101, 页码: 98975-98984
作者:
Liu, Gang
;
Song, Shanshan
;
Liu, Xiaohua
;
Zhang, Ao
;
Miao, Zehong
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
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