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科研机构
上海药物研究所 [343]
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期刊论文 [337]
会议论文 [6]
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2021 [13]
2020 [10]
2019 [10]
2018 [15]
2017 [9]
2016 [16]
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Chemistry [42]
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Site-specific protein modification by 3-n-butylphthalide in primary hepatocytes: Covalent protein adducts diminished by glutathione and N-acetylcysteine
期刊论文
LIFE SCIENCES, 2021, 卷号: 287, 页码: 14
作者:
Xue, Yaru
;
Ren, Xuelian
;
Zhu, Zhengdan
;
Lei, Peng
;
Liu, Mengling
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/18
3-n-butylphthalide
Hepatotoxicity
Oxidative stresses
Covalent protein modification
Drug-drug interaction
A simultaneous identification and quantification strategy for determination of sulfhydryl-containing metabolites in normal- and high-fat diet hamsters using stable isotope labeling combined with LC-MS
期刊论文
ANALYTICA CHIMICA ACTA, 2021, 卷号: 1184, 页码: 13
作者:
Chang, Lu
;
Lin, Feifei
;
Cheng, Kai
;
Li, Jiaomeng
;
Sun, Xiaochu
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2022/01/18
Sulfhydryl-containing metabolites
Stable isotope labeling
Identification
Quantification
Hyperlipidemia
Oxidative stress
A validated HPLC-MS/MS method for determination of simmitecan and its metabolite chimmitecan in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor
期刊论文
JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 8
作者:
Zhou, Jun
;
Zhan, Yan
;
Zhong, Dafang
;
Chen, Xiaoyan
;
Zhang, Yifan
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2021/11/04
chimmitecan
mass spectrometry
pharmacokinetics
simmitecan
solid tumors
Desorption electrospray ionization (DESI) source coupling ion mobility mass spectrometry for imaging fluoropezil (DC20) distribution in rat brain
期刊论文
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2021, 页码: 13
作者:
Guo, Runcong
;
Zhou, Lei
;
Chen, Xiaoyan
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/11/04
DESI
Mass spectrometry imaging
Fluoropezil (DC20)
Brain distribution
Optimization strategy
Liquid chromatography-mass spectrometry method for the quantification of an anti-sclerostin monoclonal antibody in cynomolgus monkey serum
期刊论文
JOURNAL OF PHARMACEUTICAL ANALYSIS, 2021, 卷号: 11, 期号: 4, 页码: 472-479
作者:
Gao, Yuxiong
;
Chen, Zhendong
;
Yang, Changyong
;
Zhong, Dafang
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/11/04
Anti-sclerostin monoclonal antibody (SHR-1222)
LC-MS/MS
Anti-drug antibody
Toxicokinetic
Fast determination of 16 circulating neurotransmitters and their metabolites in plasma samples of spontaneously hypertensive rats intervened with five different Uncaria
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2021, 卷号: 1179, 页码: 9
作者:
Gao, Lei
;
Zhang, Zijia
;
Feng, Zijin
;
Wei, Wenlong
;
Wu, Wenyong
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/11/04
Neurotransmitters
LC-MS
Hypertension
Uncaria
Spontaneously hypertensive rats
Blood Pyrrole-DNA Adducts Define the Early Tumorigenic Risk in Patients with Pyrrolizidine Alkaloid-Induced Liver Injury
期刊论文
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS, 2021, 卷号: 8, 期号: 7, 页码: 551-557
作者:
He, Yisheng
;
Zhang, Wei
;
Ma, Jiang
;
Xia, Qingsu
;
Song, Zijing
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/08/17
Systematic characterization of chemical constituents in Mahuang decoction by UHPLC tandem linear ion trap-Orbitrap mass spectrometry coupled with feature-based molecular networking
期刊论文
JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 11
作者:
Chen, Ling
;
Yao, Changliang
;
Li, Jiayuan
;
Wang, Jing
;
Yao, Shuai
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2021/08/17
feature‐
based molecular networking
linear ion trap‐
Orbitrap
Mahuang decoction
traditional Chinese medicine
Simultaneous determination of forsythin and its major metabolites in human plasma via liquid chromatography-tandem mass spectrometry
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 198, 页码: 7
作者:
Pan, Lu-lu
;
Chen, Tao
;
Hui, Min
;
Wang, Shuo
;
Fu, Li
收藏
  |  
浏览/下载:128/0
  |  
提交时间:2021/05/24
LC-MS/MS
Forsythin
Aglycone glucuronide
Aglycone sulfate
Pharmacokinetics
Recent advances in chemical analysis of licorice (Gan-Cao)
期刊论文
FITOTERAPIA, 2021, 卷号: 149, 页码: 12
作者:
Cheng, Mengzhen
;
Zhang, Jianqing
;
Yang, Lin
;
Shen, Shijie
;
Li, Ping
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/05/24
Glycyrrhiza uralensis
Glycyrrhiza glabra
Glycyrrhiza inflata
Gan-Cao
Qualitative and quantitative analysis
Biological sample
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