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科研机构
上海药物研究所 [43]
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期刊论文 [43]
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2020 [2]
2019 [2]
2018 [7]
2017 [4]
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A Peptide Binder of E3 Ligase Adaptor SPOP Disrupts Oncogenic SPOP-Protein Interactions in Kidney Cancer Cells
期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2020, 页码: 274-280
作者:
Wang, Zhen
;
Zhang, Hao
;
Chen, Baoen
;
Ouyang, Sisheng
;
Zheng, Tong
收藏
  |  
浏览/下载:124/0
  |  
提交时间:2021/05/24
SPOP
Protein‐
protein interaction
Clear cell Renal Cell Carcinomas
Crystal structure
Peptide inhibitor
Structure-Activity Relationship of SPOP Inhibitors against Kidney Cancer
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 9, 页码: 4849-4866
作者:
Dong, Ze
;
Wang, Zhen
;
Guo, Zhong-Qiang
;
Gong, Shouzhe
;
Zhang, Tao
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2020/07/01
Activation and function of receptor tyrosine kinases in human clear cell renal cell carcinomas
期刊论文
BMC CANCER, 2019, 卷号: 19, 期号: 1, 页码: 13
作者:
Zhang, Qing
;
Liu, Jian-He
;
Liu, Jing-Li
;
Qi, Chun-Ting
;
Yan, Lei
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2020/07/01
Receptor tyrosine kinases (RTKs)
Activation and function
Clear cell renal cell carcinomas (ccRCCs)
Targeted therapy
PDGFR beta
Stroma cells
Roles of Renal Drug Transporter in Drug Disposition and Renal Toxicity
期刊论文
DRUG TRANSPORTERS IN DRUG DISPOSITION, EFFECTS AND TOXICITY, 2019, 卷号: 1141, 页码: 341-360
作者:
Yang, Xinning
;
Han, Li
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  |  
浏览/下载:8/0
  |  
提交时间:2020/07/01
SLC transporters
ABC transporters
Drug disposition
Nephrotoxicity
Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma
期刊论文
ONCOGENESIS, 2018, 卷号: 7
作者:
Chen, Wei
;
Zhang, Hao
;
Chen, Zhifeng
;
Jiang, Hao
;
Liao, Liping
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  |  
浏览/下载:108/0
  |  
提交时间:2019/01/08
Genomic Heterogeneity and the Small Renal Mass
期刊论文
CLINICAL CANCER RESEARCH, 2018, 卷号: 24, 期号: 17, 页码: 4137-4144
作者:
Ueno, Daiki
;
Xie, Zuoquan
;
Boeke, Marta
;
Syed, Jamil
;
Nguyen, Kevin A.
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  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
Glycyrrhizin has a high likelihood to be a victim of drug-drug interactions mediated by hepatic organic anion-transporting polypeptide 1B1/1B3
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2018, 卷号: 175, 期号: 17, 页码: 3486-3503
作者:
Dong, Jiajia
;
Olaleye, Olajide E.
;
Jiang, Rongrong
;
Li, Jing
;
Lu, Chuang
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  |  
浏览/下载:98/0
  |  
提交时间:2019/01/08
Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy
期刊论文
ACTA PHARMACEUTICA SINICA B, 2018, 卷号: 8, 期号: 4, 页码: 552-562
作者:
Liu, Feifei
;
Yang, Xiaotong
;
Geng, Meiyu
;
Huang, Min
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  |  
浏览/下载:33/0
  |  
提交时间:2019/01/08
Mitogen-activated protein kinases
Extracellular signal-regulated kinase
ERK inhibitor
ERK kinase
Cancer therapy
Drug resistance
A sensitive LC-MS/MS method for simultaneous determination of cabozantinib and its metabolite cabozantinib N-oxide in rat plasma and its application in a pharmacokinetic study
期刊论文
BIOMEDICAL CHROMATOGRAPHY, 2018, 卷号: 32, 期号: 7
作者:
Ren, Lian-jie
;
Wu, Hua-jing
;
Sun, Li-han
;
Xu, Xue
;
Mo, Li-ying
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
cabozantinib
cabozantinib N-oxide
LC-MS
MS
pharmacokinetics
plasma
Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search
期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 3
作者:
Ding, Hong
;
Lu, Wen Chao
;
Hu, Jun Chi
;
Liu, Yu-Chih
;
Zhang, Chen Hua
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  |  
浏览/下载:50/0
  |  
提交时间:2019/01/08
SET7
inhibitor
similarity search
ligand-based drug design
chemical biology probe
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