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科研机构
上海药物研究所 [18]
内容类型
期刊论文 [18]
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2021 [2]
2020 [2]
2018 [3]
2017 [1]
2015 [1]
2014 [3]
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Expression, purification and characterization of the second DUSP domain of deubiquitinase USP20/VDU2
期刊论文
PROTEIN EXPRESSION AND PURIFICATION, 2021, 卷号: 181, 页码: 6
作者:
Hu, Shuwei
;
Chen, Xiaoyu
;
Zhu, Mengying
;
Hu, Huifang
;
Zhou, Chen
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/05/24
Deubiquitinase
USP20
DUSP domain
NMR
Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 2, 页码: 488-504
作者:
Liu, Xiaohua
;
Zhang, Yu
;
Li, Yalei
;
Wang, Juan
;
Ding, Huaqian
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/05/24
Medulloblastoma
Hedgehog signaling
pathway
Drug resistance
GLI
BRD4
Integrin beta 3 Deficiency Results in Hypertriglyceridemia via Disrupting LPL (Lipoprotein Lipase) Secretion
期刊论文
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2020, 卷号: 40, 期号: 5, 页码: 1296-1310
作者:
Xiao, Bing
;
Mao, Jianhua
;
Sun, Boyang
;
Zhang, Wei
;
Wang, Yun
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
integrins
lipoprotein lipase
lipoproteins
protein kinase D
thrombasthenia
RIPK1 inhibitor ameliorates colitis by directly maintaining intestinal barrier homeostasis and regulating following IECs-immuno crosstalk
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 172, 页码: 16
作者:
Lu, Huimin
;
Li, Heng
;
Fan, Chen
;
Qi, Qing
;
Yan, Yuxi
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2020/07/01
RIPK1 inhibitor
Colitis
Barrier homeostasis
IECs-immunocytes crosstalk
Necroptosis
NF-kappa B
Discovery of novel high potent and cellular active ADC type PTP1B inhibitors with selectivity over TC-PTP via modification interacting with C site
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 144, 页码: 692-700
作者:
Du, Yongli
;
Zhang, Yanhui
;
Ling, Hao
;
Li, Qunyi
;
Shen, Jingkang
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
Protein tyrosine phosphatase 1B inhibitors
N-(2,5-diethoxy-phenyl)-methane sulfonamide
Type 2 diabetes mellitus
PTP1B
Computational insights into the G-protein-biased activation and inactivation mechanisms of the mu opioid receptor
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 1, 页码: 154-164
作者:
Cheng, Jian-xin
;
Cheng, Tao
;
Li, Wei-hua
;
Liu, Gui-xia
;
Zhu, Wei-liang
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
G-protein-coupled receptor
mu opioid receptor
molecular dynamics
activation switch
G-protein bias
beta-arrestin signaling
TRV130
BU72
beta-FNA
naltrexone
computationalinsightsintothegproteinbiasedactivationandinactivationmechanismsoftheopioidreceptor
期刊论文
actapharmacologicasinica, 2018, 卷号: 39, 期号: 1, 页码: 154
作者:
Cheng Jianxin
;
Cheng Tao
;
Li Weihua
;
Liu Guixia
;
Zhu Weiliang
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
G-protein-coupled receptor
μ opioid receptor
molecular dynamics
activation switch
G-protein bias
β-arrestin signaling
TRV130
BU72
β-FNA
naltrexone
Phosphorylation of Pkp1 by RIPK4 regulates epidermal differentiation and skin tumorigenesis
期刊论文
EMBO JOURNAL, 2017, 卷号: 36, 期号: 13, 页码: 1963-1980
作者:
Lee, Philbert
;
Jiang, Shangwen
;
Li, Yuanyuan
;
Yue, Jiping
;
Gou, Xuewen
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2019/01/08
differentiation
epidermal progenitor cell
skin
tumorigenesis
Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 21, 页码: 7079-7088
作者:
Liu, Peihong
;
Du, Yongli
;
Song, Lianhua
;
Shen, Jingkang
;
Li, Qunyi
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Type 2 diabetes mellitus
PTP1B
Inhibitor
Structure-activity relationships
The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury
期刊论文
CELL DEATH & DISEASE, 2014, 卷号: 5
作者:
Li, J-X
;
Feng, J-M
;
Wang, Y.
;
Li, X-H
;
Chen, X-X
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
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