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科研机构
上海药物研究所 [22]
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期刊论文 [22]
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2021 [2]
2020 [1]
2019 [2]
2018 [4]
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Forrestiacids A and B, Pentaterpene Inhibitors of ACL and Lipogenesis: Extending the Limits of Computational NMR Methods in the Structure Assignment of Complex Natural Products
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 7
作者:
Xiong, Juan
;
Zhou, Peng-Jun
;
Jiang, Hao-Wen
;
Huang, Ting
;
He, Yu-Hang
收藏
  |  
浏览/下载:89/0
  |  
提交时间:2021/11/04
forrestiacids
lipogenesis inhibitors
natural products
structure elucidation
terpenoids
S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis
期刊论文
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2021, 卷号: 11, 期号: 3, 页码: 697-724
作者:
Zhang, Linqiang
;
Zhang, Zhiguo
;
Li, Chengbin
;
Zhu, Tingting
;
Gao, Jing
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/05/24
NAFLD
S100A11
FOXO1
Autophagy
Lipid Metabolism
AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced animal models
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:
Sun, Shui-mei
;
Xie, Zhi-fu
;
Zhang, Yang-ming
;
Zhang, Xin-wen
;
Zhou, Chen-dong
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/12/24
adenosine 5 '-monophosphate-activated protein kinase
AMPK activator
C24
liver
triglycerides
cholesterol
VLDL
hypolipidemic drug
metabolic syndrome
Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene
期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10, 页码: 13
作者:
Han, Yamei
;
Hu, Zhimin
;
Cui, Aoyuan
;
Liu, Zhengshuai
;
Ma, Fengguang
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
Inhibition of HSP90 beta Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System
期刊论文
THERANOSTICS, 2019, 卷号: 9, 期号: 20, 页码: 5769-5783
作者:
Zheng, Zu-Guo
;
Zhang, Xin
;
Liu, Xiao-Xiao
;
Jin, Xiu-Xiu
;
Dai, Lunzhi
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
HSP90 beta
lipid metabolism
corylin
SREBPs
proteasomal degradation
Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN
期刊论文
NATURE COMMUNICATIONS, 2018, 卷号: 9
作者:
Liu, Bin
;
Jiang, Shangwen
;
Li, Min
;
Xiong, Xuelian
;
Zhu, Mingrui
收藏
  |  
浏览/下载:109/0
  |  
提交时间:2019/01/08
Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 10, 页码: 1622-1632
作者:
Zhang, Mei
;
Xie, Zhi-fu
;
Zhang, Run-tao
;
Chen, Da-kai
;
Gu, Min
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
non-alcoholic fatty liver disease
AMP-activated protein kinase
AMPK activator
homogeneous time-resolved fluorescence
metabolic disorders
ob/ob mice
Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nuclear Factor-Like 2 Activation
期刊论文
The American journal of pathology, 2018, 卷号: 188, 期号: 8, 页码: 1833-1846
作者:
Li, Yuan
;
Chao, Xiaojuan
;
Yang, Li
;
Lu, Qian
;
Li, Tiangang
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
Effect of Medium-chain Fatty Acid-sensing Receptor GPR84 on Glucose and Lipid Metabolism in Mice
期刊论文
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2018, 卷号: 45, 期号: 8, 页码: 853-864
作者:
Fang You-Chen
;
Zheng Yang
;
Zheng Qing
;
Li Jing
;
Xie Xin
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
GPR84
medium-chain fatty acid-sensing receptor
obesity
lipid metabolism
hypercholesterolemia
Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 41, 页码: 67071-67086
作者:
Qian, Jianchang
;
Chen, Yaqing
;
Meng, Tao
;
Ma, Lanping
;
Meng, Lanfang
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
mTOR kinase inhibitor
mTORC2
apoptosis
lipid metabolism
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