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科研机构
上海药物研究所 [15]
内容类型
期刊论文 [15]
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2021 [1]
2020 [1]
2019 [2]
2018 [5]
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2011 [2]
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Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation
期刊论文
JOURNAL OF ADVANCED RESEARCH, 2021, 卷号: 33, 页码: 241-251
作者:
Li, Heng
;
Zhang, Xianglei
;
Xiang, Caigui
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2021/11/04
PDE4
Arctigenin
Psoriasis
Inflammation
Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 15
作者:
Liu, Zehui
;
Hu, Qian
;
Wang, Wanyan
;
Lu, Sisi
;
Wu, Dang
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  |  
浏览/下载:29/0
  |  
提交时间:2020/12/24
Multiple sclerosis
DHODH
Piperine
Natural product
Supersaturated polymeric micelles for oral silybin delivery: the role of the Soluplus-PVPVA complex
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 1, 页码: 107-117
作者:
Zhu, Chunliu
;
Gong, Shuang
;
Ding, Jinsong
;
Yu, Miaorong
;
Ahmad, Ejaj
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  |  
浏览/下载:130/0
  |  
提交时间:2020/07/01
Silybin
Soluplus
PVPVA
Complex
Supersaturated drug delivery system
Oral bioavailability
supersaturatedpolymericmicellesfororalsilybindeliverytheroleofthesolupluspvpvacomplex
期刊论文
actapharmaceuticasinicab, 2019, 卷号: 9, 期号: 1, 页码: 107
作者:
Zhu Chunliu
;
Gong Shuang
;
Ding Jinsong
;
Yu Miaorong
;
Ahmad Ejaj
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2020/07/01
SOLUBILITY-PERMEABILITY INTERPLAY
WATER-SOLUBLE DRUGS
MEMBRANE-TRANSPORT
FORMULATION DESIGN
IN-VITRO
SYSTEM
BIOAVAILABILITY
ABSORPTION
IMPACT
DISSOLUTION
Silybin
Soluplus
PVPVA
Complex
Supersaturated drug delivery system
Oral bioavailability
Application of ITC-Based Characterization of Thermodynamic and Kinetic Association of Ligands With Proteins in Drug Design
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Su, Haixia
;
Xu, Yechun
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  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
ITC
thermodynamics
kinetics
protein-ligand recognition
drug design
Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells
期刊论文
HAEMATOLOGICA, 2018, 卷号: 103, 期号: 9, 页码: 1472-1483
作者:
Wu, Dang
;
Wang, Wanyan
;
Chen, Wuyan
;
Lian, Fulin
;
Lang, Li
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  |  
浏览/下载:37/0
  |  
提交时间:2019/01/08
Synthesis and antibacterial activity of C-2 or C-5 modified and D ring rejiggered canthin-6-one analogues
期刊论文
FOOD CHEMISTRY, 2018, 卷号: 253, 页码: 211-220
作者:
Dai, Jiangkun
;
Dan, Wenjia
;
Li, Nian
;
Wang, Ruixue
;
Zhang, Yao
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
Synthesis
Canthin-6-one analogues
Antibacterial
Structure-activity relationships
Cell membrane
DNA topoisomerases
From hit to lead: Structure-based discovery of naphthalene-1 sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 154, 页码: 44-59
作者:
Gao, Ding-Ding
;
Dou, Hui-Xia
;
Su, Hai-Xia
;
Zhang, Ming-Ming
;
Wang, Ting
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
FABP4 inhibitors
FABP3 sparing
Structure-based design strategy
X-ray crystallography
Design and synthesis of 2-(4,5,6,7-tetrahydrothienopyridin-2-yl)-benzoimidazole carboxamides as novel orally efficacious Poly(ADP-ribose)polymerase (PARP) inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 145, 页码: 389-403
作者:
Chen, Xuxing
;
Huan, Xiajuan
;
Liu, Qiufeng
;
Wang, Yuqin
;
He, Qian
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
PARP1/2 inhibitor
Benzimidazole
4,5,6,7-Tetrahydrothienopyridine
Co-crystal structure
Isothermal Titration Calorimetry
Discovery of two aminoglycoside antibiotics as inhibitors targeting the menin-mixed lineage leukaemia interface
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 卷号: 24, 期号: 9, 页码: 2090-2093
作者:
Li, Lianchun
;
Zhou, Ran
;
Geng, Heji
;
Yue, Liyan
;
Ye, Fei
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Menin
Mixed lineage leukaemia
Pharmacophore-based virtual screening
Inhibitors
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