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科研机构
上海药物研究所 [24]
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期刊论文 [24]
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2021 [2]
2019 [2]
2018 [2]
2017 [2]
2016 [3]
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Chemistry [1]
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Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220, 页码: 18
作者:
Xu, Dandan
;
Sun, Deqiao
;
Wang, Wei
;
Peng, Xia
;
Zhan, Zhengsheng
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/08/17
Axl
Cancer
Inhibitor
Pyrrolo[2,3-d]pyrimidine
The antifungal activity and mechanisms of action of quantified extracts from berries, leaves and roots of Phytolacca tetramera
期刊论文
PHYTOMEDICINE, 2019, 卷号: 60, 页码: 9
作者:
Butassi, Estefania
;
Svetaz, Laura A.
;
Zhou, Shuaizhen
;
Wolfender, Jean-Luc
;
Cortes, Juan C. G.
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  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
Phytolacca tetramera
Quantified extracts
Candida albicans
Candida glabrata
Phytolaccagenin
Phytolaccoside B
A patent review of arginine methyltransferase inhibitors (2010-2018)
期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2019, 卷号: 29, 期号: 2, 页码: 97-114
作者:
Li, Xiao
;
Wang, Chen
;
Jiang, Hao
;
Luo, Cheng
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/07/01
Arginine methylation
Protein arginine methyltransferases (PRMTs)
small molecule inhibitors
drug research and development
Discovery and structure-activity-relationship study of novel imidazole cyclopropyl amine analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3808-3812
作者:
Zheng, Qiangang
;
Chen, Ziqi
;
Wan, Huixin
;
Tang, Shuai
;
Ye, Yan
收藏
  |  
浏览/下载:235/0
  |  
提交时间:2019/01/08
IDH1 inhibitor
Imidazole cyclopropyl amine
Structure-based rational design
Design, synthesis and biological evaluation of tetrahydronaphthyridine derivatives as bioavailable CDK4/6 inhibitors for cancer therapy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 148, 页码: 140-153
作者:
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  |  
浏览/下载:69/0
  |  
提交时间:2019/01/08
Structure-based drug design
Selective CDK4/6 inhibitors
Structure-activity relationship study
In vivo antitumor activity
Discovery and structure-activity-relationship study of novel conformationally restricted indane analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5262-5266
作者:
Zheng, Qiangang
;
Tang, Shuai
;
Fu, Xianlei
;
Chen, Ziqi
;
Ye, Yan
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
IDH1 inhibitor
Indane amide
Structure-based rational design
Identification of Epigallocatechin-3-Gallate as an Inhibitor of Phosphoglycerate Mutase 1
期刊论文
FRONTIERS IN PHARMACOLOGY, 2017, 卷号: 8
作者:
Li, Xiaoguang
;
Tang, Shuai
;
Wang, Qian-Qian
;
Leung, Elaine L. -H.
;
Jin, Hongyue
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
phosphoglycerate mutase 1 (PGAM1)
inhibitor
cancer metabolism
natural products
anticancer activity
Sodium dodecyl sulfate/beta-cyclodextrin vesicles embedded in chitosan gel for insulin delivery with pH-selective release
期刊论文
ACTA PHARMACEUTICA SINICA B, 2016, 卷号: 6, 期号: 4, 页码: 344-351
作者:
Li, Zhuo
;
Li, Haiyan
;
Wang, Caifen
;
Xu, Jianghui
;
Singh, Vikramjeet
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
Vesicles
beta-Cyclodexl
Insulin
Self-assembly
Gel
pH-selective release
Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b] [1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 116, 页码: 239-251
作者:
Zhan, Zhengsheng
;
Peng, Xia
;
Liu, Qiufeng
;
Chen, Fang
;
Ji, Yinchun
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2019/01/08
Antitumor
c-Met
Kinase inhibitor
Triazolotriazines
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