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科研机构
上海药物研究所 [22]
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期刊论文 [22]
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2021 [1]
2020 [2]
2018 [1]
2017 [3]
2016 [3]
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A novel low systemic diacylglycerol acyltransferase 1 inhibitor, Yhhu2407, improves lipid metabolism
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2021, 卷号: 158, 页码: 9
作者:
Huang, Jun-Shang
;
Guo, Bin-Bin
;
Lin, Fei-Fei
;
Zeng, Li-Min
;
Wang, Ting
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/05/24
DGAT1
Inhibitor
Pharmacokinetics
Dyslipidemia
Lipid metabolism
Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway
期刊论文
MOLECULAR METABOLISM, 2020, 卷号: 41, 页码: 15
作者:
Liu, Siwen
;
Huang, Suling
;
Wu, Xingde
;
Feng, Ying
;
Shen, Yu
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2020/12/24
Salt-inducible kinase 1
Phanginin A
Phosphodiesterase 4
Gluconeogenesis
cAMP
AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced animal models
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:
Sun, Shui-mei
;
Xie, Zhi-fu
;
Zhang, Yang-ming
;
Zhang, Xin-wen
;
Zhou, Chen-dong
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/12/24
adenosine 5 '-monophosphate-activated protein kinase
AMPK activator
C24
liver
triglycerides
cholesterol
VLDL
hypolipidemic drug
metabolic syndrome
Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 10, 页码: 1622-1632
作者:
Zhang, Mei
;
Xie, Zhi-fu
;
Zhang, Run-tao
;
Chen, Da-kai
;
Gu, Min
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
non-alcoholic fatty liver disease
AMP-activated protein kinase
AMPK activator
homogeneous time-resolved fluorescence
metabolic disorders
ob/ob mice
Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 139, 页码: 128-152
作者:
Wang, Zhengyu
;
Shi, Xiaofan
;
Zhang, Huan
;
Yu, Liang
;
Cheng, Yanhua
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/01/08
Type 2 diabetes mellitus
Hypoglycemia
Dyslipidemia
Glucokinase activators
N-Thiazol-2-yl-benzamides
A novel glucagon-like peptide-1/glucagon receptor dual agonist exhibits weight-lowering and diabetes-protective effects
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 138, 页码: 1158-1169
作者:
Zhou, Jie
;
Cai, Xingguang
;
Huang, Xun
;
Dai, Yuxuan
;
Sun, Lidan
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
Glucagon
GLP-1/GCGR agonist
Weight-lowering
Diabetes-protective
Plantago asiatica L. Seed Extract Improves Lipid Accumulation and Hyperglycemia in High-Fat Diet-Induced Obese Mice
期刊论文
International journal of molecular sciences, 2017, 卷号: 18, 期号: 7
作者:
Yang, Qiming
;
Qi, Meng
;
Tong, Renchao
;
Wang, Dandan
;
Ding, Lili
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Discovery, synthesis, and structure-activity relationships of 20S-dammar-24-en-2 alpha,3 beta,12 beta,20-tetrol (GP) derivatives as a new class of AMPK alpha 2 beta 1 gamma 1 activators
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 卷号: 24, 期号: 12, 页码: 2688-2696
作者:
Dong, Chenhuan
;
Xie, Zhifu
;
Yu, Yanyan
;
Li, Jia
;
Liu, Junhua
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Gynostemma yixingense
Dammarane-type
AMPK
AMPK heterotrimer alpha 2 beta 1 gamma 1
Activators
Structure-activity relationships
Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice
期刊论文
DIABETOLOGIA, 2016, 卷号: 59, 期号: 6, 页码: 1276-1286
作者:
Feng, Li
;
Luo, Huan
;
Xu, Zhijian
;
Yang, Zhuo
;
Du, Guoxin
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2019/01/08
Alternative binding site
Bavachinin
Canonical ligand-binding pocket
Carbohydrate metabolism
Lipid metabolism
Pan-PPAR agonist
Synergistic effects
Emodin improves lipid and glucose metabolism in high fat diet-induced obese mice through regulating SREBP pathway
期刊论文
European journal of pharmacology, 2016, 卷号: 770, 页码: 99-109
作者:
Li, Jinmei
;
Ding, Lili
;
Song, Baoliang
;
Xiao, Xu
;
Qi, Meng
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
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