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科研机构
上海药物研究所 [111]
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期刊论文 [108]
会议论文 [3]
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2021 [5]
2020 [9]
2019 [10]
2018 [9]
2017 [4]
2016 [14]
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Chemistry [2]
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Lipophilic Conjugates of Drugs: A Tool to Improve Drug Pharmacokinetic and Therapeutic Profiles
期刊论文
PHARMACEUTICAL RESEARCH, 2021, 页码: 22
作者:
Han, Sifei
;
Mei, Lianghe
;
Quach, Tim
;
Porter, Chris
;
Trevaskis, Natalie
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/11/04
conjugate
lipid
lymphatic
pharmacokinetics
prodrug
Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 32, 页码: 8
作者:
Wang, Xi
;
Cheng, Xi
;
Zhao, Lihua
;
Wang, Yuzhe
;
Ye, Chenyu
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/11/04
parathyroid hormone receptor 2
cryo-electron microscopy
G protein-coupled receptor
ligand recognition
syndromic short stature
Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 18
作者:
Lan, Xiao-fang
;
Olaleye, Olajide E.
;
Lu, Jun-lan
;
Yang, Wei
;
Du, Fei-fei
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  |  
浏览/下载:75/0
  |  
提交时间:2021/06/11
LianhuaQingwen
glycyrrhetic acid
24-hydroxyglycyrrhetic acid
Gancao-induced pseudoaldosteronism
licorice-induced pseudoaldosteronism
11β
-hydroxysteroid dehydrogenase 2
COVID-19
colonic microbiota
Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion, and Toxicity
期刊论文
DRUG METABOLISM AND DISPOSITION, 2021, 卷号: 49, 期号: 4, 页码: 305-313
作者:
Qiao, Shida
;
Feng, Sisi
;
Wu, Zhitao
;
He, Ting
;
Ma, Chen
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/05/24
Glucose-Binding of Periplasmic Protein GltB Activates GtrS-GltR Two-Component System in Pseudomonas aeruginosa
期刊论文
MICROORGANISMS, 2021, 卷号: 9, 期号: 2, 页码: 28
作者:
Xu, Chenchen
;
Cao, Qiao
;
Lan, Lefu
收藏
  |  
浏览/下载:111/0
  |  
提交时间:2021/05/24
Pseudomonas aeruginosa
Glucose
periplasmic binding protein
two-component system
transcriptional regulation
Bufalin exerts antitumor effects in neuroblastoma via the induction of reactive oxygen species-mediated apoptosis by targeting the electron transport chain
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2020, 卷号: 46, 期号: 6, 页码: 2137-2149
作者:
Pan, Lijia
;
Nie, Litong
;
Yao, Sheng
;
Bi, Aiwei
;
Ye, Yang
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  |  
浏览/下载:29/0
  |  
提交时间:2020/12/24
neuroblastoma
bufalin
chemical proteomics
ETC
mitochondria
Drug interaction of ningetinib and gefitinib involving CYP1A1 and efflux transporters in non-small cell lung cancer patients
期刊论文
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020, 页码: 13
作者:
Liu, Lu
;
Wang, Qian
;
Xie, Cen
;
Xi, Ning
;
Guo, Zitao
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  |  
浏览/下载:57/0
  |  
提交时间:2020/12/24
drug–
drug interaction
gefitinib
ningetinib
transporters
Nuclear miR-30b-5p suppresses TFEB-mediated lysosomal biogenesis and autophagy
期刊论文
CELL DEATH AND DIFFERENTIATION, 2020, 页码: 17
作者:
Guo, Huijie
;
Pu, Mei
;
Tai, Yusi
;
Chen, Yuxiang
;
Lu, Henglei
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2020/12/24
Supramolecular Drug-Drug Complex Vesicles Enable Sequential Drug Release for Enhanced Combination Therapy
期刊论文
ACS APPLIED MATERIALS & INTERFACES, 2020, 卷号: 12, 期号: 25, 页码: 27940-27950
作者:
Liu, Chengfei
;
Li, Chunpu
;
Pang, Cui
;
Li, Muqiong
;
Li, Huixin
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/12/24
drug-drug self-delivery system
supramolecular vesicles
host-guest interaction
self-assembly
pillar[5]arene
combination therapy
Effect of phosphatidylcholine on the stability and lipolysis of nanoemulsion drug delivery systems
期刊论文
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 卷号: 583, 页码: 9
作者:
Zhang, Bo
;
Zhou, Xin
;
Miao, Yunqiu
;
Wang, Xiaoli
;
Yang, Yuting
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/12/24
Phosphatidylcholine
Nanoemulsion
Stability
Lipolysis kinetics
Curcumin
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