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科研机构
上海药物研究所 [88]
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期刊论文 [88]
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2021 [8]
2020 [6]
2019 [4]
2018 [11]
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Genetically-engineered "all-in-one" vaccine platform for cancer immunotherapy
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 11, 页码: 3622-3635
作者:
Wu, Aihua
;
Chen, Yingzhi
;
Wang, Hairui
;
Chang, Ya
;
Zhang, Meng
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/01/18
Trichosanthin
Legumain
TRP2
Transcutaneous immunization
Adjuvant
Cancer vaccine
Protein engineering
Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine
期刊论文
JOURNAL OF MOLECULAR STRUCTURE, 2021, 卷号: 1241, 页码: 14
作者:
Zhou, Xian
;
Feng, Xuexin
;
Wang, Dachi
;
Chen, Deheng
;
Wu, Gaoxing
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2021/08/17
Chaetominine
Cellular growth inhibition
Cancer cell line
Covalent warhead
Recombinant cancer nanovaccine for targeting tumor-associated macrophage and remodeling tumor microenvironment
期刊论文
NANO TODAY, 2021, 卷号: 40, 页码: 14
作者:
Tang, Yisi
;
Fan, Wufa
;
Chen, Guihua
;
Zhang, Meng
;
Tang, Xueping
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/12/01
Cancer therapeutic vaccine
Legumain
Tumor-associated macrophage
Trichosanthin
Liposome
Adjuvant
BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer
期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6, 期号: 1, 页码: 14
作者:
Feng, Mei
;
Wu, Zhongen
;
Zhou, Yan
;
Wei, Zhuang
;
Tian, Enming
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/11/04
Crataegus pinnatifida polysaccharide alleviates colitis via modulation of gut microbiota and SCFAs metabolism
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 卷号: 181, 页码: 357-368
作者:
Guo, Ciliang
;
Wang, Yeqing
;
Zhang, Shihai
;
Zhang, Xiuqi
;
Du, Zhenyun
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/08/17
pinnatifida polysaccharide
Colitis
Gut microbiota
Short chain fatty acids
Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 215, 页码: 13
作者:
Gao, Feng
;
Chen, Xiaoxu
;
Lu, Junyan
;
Hu, Shulei
;
Xu, Hui
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/05/24
Ceramide analogs
AKT inhibitor
MK2206
Colon cancer
Combination therapy
Gut Microbiota: Influence on Carcinogenesis and Modulation Strategies by Drug Delivery Systems to Improve Cancer Therapy
期刊论文
ADVANCED SCIENCE, 2021, 页码: 32
作者:
Zhu, Runqi
;
Lang, Tianqun
;
Yan, Wenlu
;
Zhu, Xiao
;
Huang, Xin
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2021/05/24
cancer therapy
carcinogenesis
drug delivery system
gut microbiota
modulation
Magnetism-mediated targeting hyperthermia-immunotherapy in "cold" tumor with CSF1R inhibitor
期刊论文
THERANOSTICS, 2021, 卷号: 11, 期号: 14, 页码: 6860-6872
作者:
Fang, Yuefei
;
He, Yang
;
Wu, Canhao
;
Zhang, Meng
;
Gu, Zeyun
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/08/17
magnetic hyperthermia
CSF1R inhibitor
tumor microenvironment
tumor-associated macrophage
immune memory
targeted delivery
magnetic liposomes
DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 10
作者:
Chen, Xiang-ling
;
Liu, Peng
;
Zhu, Wei-liang
;
Lou, Li-guang
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/07/01
DCZ5248
Hsp90
autophagy
lysosomal function
antitumor activity
colon cancer
Patchouli Alcohol: a Natural Sesquiterpene Against Both Inflammation and Intestinal Barrier Damage of Ulcerative Colitis
期刊论文
INFLAMMATION, 2020, 页码: 13
作者:
Wu, Zhuona
;
Zeng, Hairong
;
Zhang, Lili
;
Pu, Yiqiong
;
Li, Suyun
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
patchouli alcohol
ulcerative colitis
intestinal integrity
anti-inflammatory
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