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科研机构
上海药物研究所 [10]
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期刊论文 [10]
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2019 [2]
2016 [2]
2015 [1]
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2011 [2]
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1-Phenyl-dihydrobenzoindazoles as novel colchicine site inhibitors: Structural basis and antitumor efficacy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 448-456
作者:
Jiang, Junhang
;
Zhang, Hao
;
Wang, Chongqing
;
Zhang, Qingsen
;
Fang, Shaoyu
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
Microtubule-targeting agents
Colchicine site inhibitors
Cis-trans photoisomerization
X-ray co-crystal structure
Water-soluble prodrug
The Structure of MT189-Tubulin Complex Provides Insights into Drug Design
期刊论文
LETTERS IN DRUG DESIGN & DISCOVERY, 2019, 卷号: 16, 期号: 9, 页码: 1069-1073
作者:
Li, Zhongping
;
Ma, Lingling
;
Wu, Chengyong
;
Meng, Tao
;
Ma, Lanping
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/07/01
Crystal structure
tubulin
colchicine binding site
inhibitor
MT189
drug design
Potent Antitumor Activities and Structure Basis of the Chiral beta-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 22, 页码: 10329-10334
作者:
Zhou, Pengfei
;
Liu, Yan
;
Zhou, Lu
;
Zhu, Kongkai
;
Feng, Kechang
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 112, 页码: 367-372
作者:
An, Weiteng
;
Wang, Wei
;
Yu, Ting
;
Zhang, Yongliang
;
Miao, Zehong
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Anticancer agents
Tubulin inhibitor
Intra-molecular hydrogen bonding
Colchicine binding site
Dual targeting of microtubule and topoisomerase II by alpha-carboline derivative YCH337 for tumor proliferation and growth inhibition
期刊论文
ONCOTARGET, 2015, 卷号: 6, 期号: 11, 页码: 8960-8973
作者:
Yi, Jun-Mei
;
Zhang, Xiao-Fei
;
Huan, Xia-Juan
;
Song, Shan-Shan
;
Wang, Wei
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
YCH337
alpha-carboline derivative
microtubule
topoisomerase II
antitumor activity
MCL-1 Degradation Mediated by JNK Activation via MEKK1/TAK1-MKK4 Contributes to Anticancer Activity of New Tubulin Inhibitor MT189
期刊论文
MOLECULAR CANCER THERAPEUTICS, 2014, 卷号: 13, 期号: 6, 页码: 1480-1491
作者:
Wang, Wei
;
Wang, Ying-Qing
;
Meng, Tao
;
Yi, Jun-Mei
;
Huan, Xia-Juan
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
Synthesis and biological evaluation of 6H-pyrido[2 ',1 ':2,3] imidazo[4,5-c] isoquinolin-5(6H)-ones as antimitotic agents and inhibitors of tubulin polymerization
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 2, 页码: 848-855
作者:
Meng, Tao
;
Wang, Wei
;
Zhang, Zhixiang
;
Ma, Lanping
;
Zhang, Yongliang
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
6H-Pyrido[2 ',1 ':2,3]imidazo[4,5-c]
isoquinolin-5(6H)-ones
Antitumor agents
Inhibitors of tubulin polymerization
Colchicine binding site
YHHU0895, a novel synthetic small-molecule microtubule-destabilizing agent, effectively overcomes P-glycoprotein-mediated tumor multidrug resistance
期刊论文
CANCER LETTERS, 2012, 卷号: 314, 期号: 1, 页码: 54-62
作者:
Zhao, Hongbing
;
Quan, Haitian
;
Xie, Chengying
;
Xu, Yongping
;
Xie, Fuchun
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
YHHU0895
Microtubule
P-glycoprotein
Multidrug resistance
Microtubule-destabilizing agent
MT119, a new planar-structured compound, targets the colchicine site of tubulin arresting mitosis and inhibiting tumor cell proliferation
期刊论文
INTERNATIONAL JOURNAL OF CANCER, 2011, 卷号: 129, 期号: 1, 页码: 214-224
作者:
Zhang, Zhixiang
;
Meng, Tao
;
Yang, Na
;
Wang, Wei
;
Xiong, Bing
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
mitosis
tubulin
the colchicine site
spindle assembly
Synthesis and Biological Evaluation of 2,4,5-Substituted Pyrimidines as a New Class of Tubulin Polymerization Inhibitors
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2011, 卷号: 54, 期号: 9, 页码: 3200-3205
作者:
Xie, Fuchun
;
Zhao, Hongbing
;
Li, Dewen
;
Chen, Hong
;
Quan, Haitian
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
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