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科研机构
上海药物研究所 [34]
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期刊论文 [34]
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2021 [4]
2020 [3]
2019 [7]
2018 [4]
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ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker
期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6, 期号: 1, 页码: 9
作者:
Chen, Yuning
;
Zhang, Ya-Nan
;
Yan, Renhong
;
Wang, Guifeng
;
Zhang, Yuanyuan
收藏
  |  
浏览/下载:67/0
  |  
提交时间:2021/11/04
Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Wang, Lin
;
Wu, Yan
;
Yao, Sheng
;
Ge, Huan
;
Zhu, Ya
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2021/11/04
SARS-CoV-2
natural products
virtual screening
spike protein
protein-protein interaction modulators
Liquid chromatography-mass spectrometry method for the quantification of an anti-sclerostin monoclonal antibody in cynomolgus monkey serum
期刊论文
JOURNAL OF PHARMACEUTICAL ANALYSIS, 2021, 卷号: 11, 期号: 4, 页码: 472-479
作者:
Gao, Yuxiong
;
Chen, Zhendong
;
Yang, Changyong
;
Zhong, Dafang
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/11/04
Anti-sclerostin monoclonal antibody (SHR-1222)
LC-MS/MS
Anti-drug antibody
Toxicokinetic
Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2021, 页码: 20
作者:
Liu, Chenglong
;
Zhou, Feilong
;
Yan, Ziqin
;
Shen, Lian
;
Zhang, Xichen
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/06/11
immunotherapy
PD-1/PD-L1
TGF-beta
tumour immune microenvironment
Dual Mechanisms of Novel CD73-Targeted Antibody and Antibody-Drug Conjugate in Inhibiting Lung Tumor Growth and Promoting Antitumor Immune-Effector Function
期刊论文
MOLECULAR CANCER THERAPEUTICS, 2020, 卷号: 19, 期号: 11, 页码: 2340-2352
作者:
Jin, Rui
;
Liu, Liang
;
Xing, Yun
;
Meng, Tao
;
Ma, Lanping
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2020/12/24
An antibody-drug conjugate targeting a GSTA glycosite-signature epitope of MUC1 expressed by non-small cell lung cancer
期刊论文
CANCER MEDICINE, 2020, 页码: 12
作者:
Pan, Deng
;
Tang, Yubo
;
Tong, Jiao
;
Xie, Chengmei
;
Chen, Jiaxi
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/12/24
Engineering Polymeric Prodrug Nanoplatform for Vaccination Immunotherapy of Cancer
期刊论文
NANO LETTERS, 2020, 卷号: 20, 期号: 6, 页码: 4393-4402
作者:
Zhou, Lei
;
Hou, Bo
;
Wang, Dangge
;
Sun, Fang
;
Song, Rundi
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2020/12/24
Polymeric prodrug
Neoantigen
Adaptive immune response
Personalized immunotherapy
Nanoparticles
Two validated liquid chromatography-mass spectrometry methods with different pretreatments for the quantification of an anti-CD47 monoclonal antibody in rat and cynomolgus monkey serum compared with an electrochemiluminescence method
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 175, 页码: 11
作者:
Gao, Yuxiong
;
Zhang, Dan
;
Yang, Changyong
;
Duan, Xiaotao
;
Li, Xiuli
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
Anti-CD47 monoclonal antibody
LC-MS
Adsorption issue
Electrochemiluminescence
Pharmacokinetics
Cross-validation
SHR-A1403, a novel c-mesenchymal-epithelial transition factor (c-Met) antibody-drug conjugate, overcomes AZD9291 resistance in non-small cell lung cancer cells overexpressing c-Met
期刊论文
CANCER SCIENCE, 2019, 页码: 11
作者:
Tong, Mengya
;
Gao, Mingzhao
;
Xu, Yongping
;
Fu, Li
;
Li, Yun
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
AZD9291
c-Met ADC
c-Met overexpression
resistance
SHR-A1403
New linker structures applied in glycosite-specific antibody drug conjugates
期刊论文
ORGANIC CHEMISTRY FRONTIERS, 2019, 卷号: 6, 期号: 17, 页码: 3144-3149
作者:
Faridoon
;
Shi, Wei
;
Qin, Ken
;
Tang, Yubo
;
Li, Mingjie
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
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