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科研机构
上海药物研究所 [75]
内容类型
期刊论文 [73]
会议论文 [1]
学位论文 [1]
发表日期
2021 [8]
2020 [3]
2019 [2]
2018 [6]
2017 [7]
2016 [10]
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Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224, 页码: 14
作者:
He, Yu-Long
;
Chen, Meng-Ting
;
Wang, Ting
;
Zhang, Ming-Ming
;
Li, Ying-Xia
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2021/11/04
Type 2 diabetes mellitus
Dual FABP4/5 inhibitors
Anti-lipolytic and anti-inflammatory effects
Metabolic stability
Anti-diabetic activities
Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation
期刊论文
JOURNAL OF ADVANCED RESEARCH, 2021, 卷号: 33, 页码: 241-251
作者:
Li, Heng
;
Zhang, Xianglei
;
Xiang, Caigui
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2021/11/04
PDE4
Arctigenin
Psoriasis
Inflammation
Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel alpha-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 115, 页码: 17
作者:
Xie, Hong-Xu
;
Zhang, Juan
;
Li, Yue
;
Zhang, Jin-He
;
Liu, Shan-Kui
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2021/11/04
Tetrahydrobenzo[b]thiophen-2-yl)urea
alpha-Glucosidase inhibitors
Non-competitive inhibitor
Molecular docking
Anti-hyperglycaemic activity
Type 2 diabetes
Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.
期刊论文
CHEMISTRY & BIODIVERSITY, 2021, 页码: 6
作者:
Fan, Min
;
Wang, Ting
;
Peng, Li-Yan
;
Huang, Jun-Shang
;
Wu, Xing-De
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/11/04
Salvia hispanica
neo-clerodane diterpenoid
salvihispin H
type 2 diabetes mellitus
Honokiol: A naturally occurring lignan with pleiotropic bioactivities
期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2021, 卷号: 19, 期号: 7, 页码: 481-490
作者:
Chen Cheng
;
Zhang Qing-Wen
;
Ye Yang
;
Lin Li-Gen
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  |  
浏览/下载:41/0
  |  
提交时间:2021/08/17
Honokiol
Natural sources
Ethnopharmacological uses
Physicochemical properties
Bioactivities
Clinical trials
Combined treatment with FABP4 inhibitor ameliorates rosiglitazone-induced liver steatosis in obese diabetic db/db mice
期刊论文
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2021, 页码: 10
作者:
Chen, Meng-Ting
;
Huang, Jun-Shang
;
Gao, Ding-Ding
;
Li, Ying-Xia
;
Wang, He-Yao
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/08/17
combined treatment
FABP4 inhibitor
liver steatosis
obese type 2 diabetes
rosiglitazone
A novel GPR120-selective agonist promotes insulin secretion and improves chronic inflammation
期刊论文
LIFE SCIENCES, 2021, 卷号: 269, 页码: 8
作者:
Yang, Liu
;
Lei, Xian-Tao
;
Huang, Qi
;
Wang, Ting
;
Sun, Hong-Bin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/05/24
GPR120 agonist
Insulin secretion
Anti-inflammation
Insulin resistance
Type 2 diabetes mellitus
SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Ren, Yu-ran
;
Ye, Yang-liang
;
Feng, Ying
;
Xu, Ti-fei
;
Shen, Yu
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
SL010110
gluconeogenesis
primary mouse hepatocytes
PEPCK1
acetylation
degradation
Identification and structural insight of an effective PPAR gamma modulator with improved therapeutic index for anti-diabetic drug discovery
期刊论文
CHEMICAL SCIENCE, 2020, 卷号: 11, 期号: 8, 页码: 2260-2268
作者:
Jiang, Haowen
;
Zhou, X. Edward
;
Shi, Jingjing
;
Zhou, Zhi
;
Zhao, Guanguan
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
siliconeelastomergelimpregnatedwith20sprotopanaxadiolloadednanostructuredlipidcarriersforordereddiabeticulcerrecovery
期刊论文
actapharmacologicasinica, 2020, 卷号: 41, 期号: 1, 页码: 119
作者:
Sun Di
;
Guo Shiyan
;
Yang Li
;
Wang Yaru
;
Wei Xiaohui
收藏
  |  
浏览/下载:88/0
  |  
提交时间:2020/07/01
Diabetic ulcer
ordered recovery
scarless wound healing
20 (S)-protopanaxadiol
nanostructured lipid carrier
silicone elastomer
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