FH  familial hypercholesterolemia  LDL-C  low-density lipoprotein cholesterol  sEH  soluble epoxide hydrolase  EPHX2  epoxide hydrolase 2  CLSM  Confocal Laser Scanning Microscope  Familial hypercholesterolemia (FH)  Epoxide hydrolase (sEH) R287Q  Hydrolase activity  LDL  LDLR  

apo  apolipoprotein  HDL  high-density lipoprotein  HNF-1α,4α  hepatocyte nuclear factor-1α,4α  LRH-1  liver receptor homolog-1  Foxa2  forkhead box A2  PAF  platelet activating factor  LXR  liver X receptor  RXR  retinoid X receptor  FXR  farnesoid X receptor  SHP  small heterodimer partner  S1P  Sphingosine-1-Phosphate  CVD  cardiovascular disease  HDL-C  HDL cholesterol  RCT  reverse cholesterol transport  MHC  major histocompatibility complex class III  TNF  tumor necrosis factor  HRP  haptoglobin-related protein  PON-I  paraoxonase-1  SNP  single nucleotide polymorphism  T1,2D  type 1,2 diabetes  RA  rheumatoid arthritis  ABCA1  ATP-binding cassette transporter A1  PPAR-γ  peroxisome proliferator-activated receptor γ  IL  interleukin  ABCG  ATP-binding cassette sub-family G  CETP  cholesteryl ester transfer protein  SR-B1  scavenger receptor class B member 1  MODY3  maturity-onset diabetes of the young type 3  MUP  major urinary protein  RBP  retinol binding protein  RAR  retinoic acid receptor  TR  thyroid hormone receptor  PI3K  phosphatidylinositol 3-kinase  DHC  dihydrocapsaicin  HRE  hormone response element  IGF-1  insulin-like growth factors  PAF-R  platelet activating factor receptor  TGF-α,β  transforming growth factor-α,β  EGF  epidermal growth factor  HGF  hepatic growth factor  VLDL  very low-density lipoprotein  LDL  low-density lipoprotein  ldlr  LDL receptor  ldlr−/−  LDL-receptor deficient  LCAT  lecithin-cholesterol acyltransferase  CE  cholesteryl ester  TC  total cholesterol  LDL-C  LDL cholesterol  VLDL-C  VLDL cholesterol  CHD  coronary heart disease  Mets  metabolic syndrome  S1PR  S1P receptor  NF-κB  nuclear factor-κB  NO  nitrogen oxide  eNOS  endothelial nitric oxide synthase  apoM-TgN mice  mice overexpressing human apoM by approximately two-fold  apoM-TgH mice  mice overexpressing human apoM by approximately ten-fold  apoM−/− mice  apoM-null mice  apoE−/−  apoE-null mice  Apolipoprotein M  Regulation  Function  

ABCG5  ABCG8  ATP-binding cassette transporter G5  ATP-binding cassette transporter G8  Atherosclerosis  Cholesterol  ER  ET  GATA-binding protein 4  GATA4  HDL  HNF4alpha  LDL-C  LDLR  LXR  NBD  NPC1L1  Niemann-Pick C1-Like 1  PUFAs  SNP  Sitosterolemia  TH  VLDL-C  apoA-I  apolipoprotein A-I  endoplasmic reticulum  endotoxin  hepatocyte nuclear factor 4alpha  high-density lipoprotein  liver X receptor  low-density lipoprotein receptor  low-density lipoprotein-cholesterol  nucleotide binding domain  polyunsaturated fatty acids  single nucleotide polymorphisms  thyroid hormone  very low-density lipoprotein-cholesterol  

LPL  Lipoprotein  Lipid  Triglyceride  Inflammation  Atherosclerosis  LPL  lipoprotein lipase  TG  triglyceride  CM  chylomicron  VLDL  very low density lipoprotein  FFA  free fatty acid  FA  fatty acid  ER  endoplasmic reticulum  LMF1  lipase maturation factor 1  SorLA  sortilin-related receptor with A-type repeats  TGN  trans Golgi network  LS  lysosome  HSPG  heparan sulfate proteoglycans  HS  heparan sulfate  EC  endothelial cell  VEC  vascular endothelial cell  VLDLR  very low density lipoprotein receptor  GPIHBP1  glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1  PPRE  peroxisome proliferator activated receptor responsive element  AP-1  anterior protein-1  PPAR  peroxisome proliferator activated receptor  RXR  retinoic acid receptor  LXR  liver X receptor  TNF  tumor necrosis factor  INF-γ  interferon-γ  PKA  protein kinase A  CRP  C-reactive protein  apoA-V  apolipoprotein A-V  apoE  apolipoprotein E  apoC  apolipoprotein C  CREB-H  cAMP–responsive element–binding protein H  Angptls  angiopoietin-like proteins  AS  atherosclerosis  TRL  triglyceride-rich lipoproteins  RLP  remnant-like lipoprotein particle  LDL  low density lipoprotein  ox-LDL  oxidized low-density lipoprotein  IL-6  interleukin-6  Ox-PLs  oxidized phospholipids  LDLR  LDL receptor  LRP  LDL-receptor associated protein  

IL-17  interleukin-17  Th17  T helper 17  IL-17R  IL-17 receptor  STAT3  signal transducer and activator of transcription 3  RORγ  retinoic acid receptor-related orphan receptor γ  IRF4  interferon regulatory factor 4  ERK  extracellular signal-regulated kinase  Ets1  E26 transformation-specific 1  15(S)-HETE  15(S)-hydroxyeicosatetraenoic acid  SF1  alternative splicing factor  MAPK  mitogen-activated protein kinase  PPARγ  peroxisome proliferator-activated receptor γ  TRAF  tumor necrosis factor receptor-associated factor  TAK1  transforming growth factor-β-activated kinase 1  TAB  TAK1-binding protein  IKK  IκB kinase  NF-κB  nuclear factor kappa-B  IKKi  inducible IKK  JNK  c-Jun N-terminal kinase  C/EBP  CCAAT/enhancer-binding protein  AP1  activator protein 1  USP  ubiquitin-specific protease  CXCL  CXC chemokine ligand  ASF  alternative splicing factor  Hsp90  heat shock protein 90  RCT  reverse cholesterol transport  ABCA1  ATP-binding cassette transporter A1  apo E  apolipoprotein E  LDLR  low-density lipoprotein receptor  FABP4  fatty acid-binding protein-4  IL-17A  IL-17RA  IL-17RC  Lipid metabolism  Atherosclerosis